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Fusion gene ID: 41534 |
FusionGeneSummary for VPS13B_SGCZ |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: VPS13B_SGCZ | Fusion gene ID: 41534 | Hgene | Tgene | Gene symbol | VPS13B | SGCZ | Gene ID | 157680 | 137868 |
| Gene name | vacuolar protein sorting 13 homolog B | sarcoglycan zeta | |
| Synonyms | CHS1|COH1 | ZSG1 | |
| Cytomap | 8q22.2 | 8p22 | |
| Type of gene | protein-coding | protein-coding | |
| Description | vacuolar protein sorting-associated protein 13B | zeta-sarcoglycanzeta-SG | |
| Modification date | 20180519 | 20180523 | |
| UniProtAcc | Q7Z7G8 | Q96LD1 | |
| Ensembl transtripts involved in fusion gene | ENST00000395996, ENST00000358544, ENST00000357162, ENST00000355155, ENST00000441350, ENST00000521932, | ENST00000382080, ENST00000421524, | |
| Fusion gene scores | * DoF score | 27 X 20 X 12=6480 | 5 X 4 X 5=100 |
| # samples | 30 | 5 | |
| ** MAII score | log2(30/6480*10)=-4.43295940727611 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(5/100*10)=-1 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: VPS13B [Title/Abstract] AND SGCZ [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | RV | LUAD | TCGA-97-8171-01A | VPS13B | chr8 | 100205285 | + | SGCZ | chr8 | 14181713 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| Frame-shift | ENST00000395996 | ENST00000382080 | VPS13B | chr8 | 100205285 | + | SGCZ | chr8 | 14181713 | - |
| 5CDS-intron | ENST00000395996 | ENST00000421524 | VPS13B | chr8 | 100205285 | + | SGCZ | chr8 | 14181713 | - |
| Frame-shift | ENST00000358544 | ENST00000382080 | VPS13B | chr8 | 100205285 | + | SGCZ | chr8 | 14181713 | - |
| 5CDS-intron | ENST00000358544 | ENST00000421524 | VPS13B | chr8 | 100205285 | + | SGCZ | chr8 | 14181713 | - |
| Frame-shift | ENST00000357162 | ENST00000382080 | VPS13B | chr8 | 100205285 | + | SGCZ | chr8 | 14181713 | - |
| 5CDS-intron | ENST00000357162 | ENST00000421524 | VPS13B | chr8 | 100205285 | + | SGCZ | chr8 | 14181713 | - |
| Frame-shift | ENST00000355155 | ENST00000382080 | VPS13B | chr8 | 100205285 | + | SGCZ | chr8 | 14181713 | - |
| 5CDS-intron | ENST00000355155 | ENST00000421524 | VPS13B | chr8 | 100205285 | + | SGCZ | chr8 | 14181713 | - |
| intron-3CDS | ENST00000441350 | ENST00000382080 | VPS13B | chr8 | 100205285 | + | SGCZ | chr8 | 14181713 | - |
| intron-intron | ENST00000441350 | ENST00000421524 | VPS13B | chr8 | 100205285 | + | SGCZ | chr8 | 14181713 | - |
| 3UTR-3CDS | ENST00000521932 | ENST00000382080 | VPS13B | chr8 | 100205285 | + | SGCZ | chr8 | 14181713 | - |
| 3UTR-intron | ENST00000521932 | ENST00000421524 | VPS13B | chr8 | 100205285 | + | SGCZ | chr8 | 14181713 | - |
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FusionProtFeatures for VPS13B_SGCZ |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| VPS13B | SGCZ |