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Fusion gene ID: 41503 |
FusionGeneSummary for VNN1_SLC18B1 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: VNN1_SLC18B1 | Fusion gene ID: 41503 | Hgene | Tgene | Gene symbol | VNN1 | SLC18B1 | Gene ID | 8876 | 116843 |
| Gene name | vanin 1 | solute carrier family 18 member B1 | |
| Synonyms | HDLCQ8|Tiff66 | C6orf192|dJ55C23.6 | |
| Cytomap | 6q23.2 | 6q23.2 | |
| Type of gene | protein-coding | protein-coding | |
| Description | pantetheinasepantetheine hydrolasevannin 1vascular non-inflammatory molecule 1 | MFS-type transporter SLC18B1MFS-type transporter C6orf192solute carrier family 18, subfamily B, member 1 | |
| Modification date | 20180523 | 20180523 | |
| UniProtAcc | O95497 | Q6NT16 | |
| Ensembl transtripts involved in fusion gene | ENST00000367928, | ENST00000275227, ENST00000538764, ENST00000367918, ENST00000460518, | |
| Fusion gene scores | * DoF score | 1 X 1 X 1=1 | 3 X 3 X 2=18 |
| # samples | 1 | 3 | |
| ** MAII score | log2(1/1*10)=3.32192809488736 | log2(3/18*10)=0.736965594166206 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | |
| Context | PubMed: VNN1 [Title/Abstract] AND SLC18B1 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | VNN1 | GO:0015939 | pantothenate metabolic process | 11491533|25478849 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | LD | LIHC | TCGA-BC-A10R-01A | VNN1 | chr6 | 133032848 | - | SLC18B1 | chr6 | 133091475 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| Frame-shift | ENST00000367928 | ENST00000275227 | VNN1 | chr6 | 133032848 | - | SLC18B1 | chr6 | 133091475 | - |
| 5CDS-intron | ENST00000367928 | ENST00000538764 | VNN1 | chr6 | 133032848 | - | SLC18B1 | chr6 | 133091475 | - |
| 5CDS-intron | ENST00000367928 | ENST00000367918 | VNN1 | chr6 | 133032848 | - | SLC18B1 | chr6 | 133091475 | - |
| 5CDS-intron | ENST00000367928 | ENST00000460518 | VNN1 | chr6 | 133032848 | - | SLC18B1 | chr6 | 133091475 | - |
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FusionProtFeatures for VNN1_SLC18B1 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| VNN1 | SLC18B1 |