|
||||||
|
 | |
| |
| |
| |
| |
|
Fusion gene ID: 41487 |
FusionGeneSummary for VMP1_C17orf64 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: VMP1_C17orf64 | Fusion gene ID: 41487 | Hgene | Tgene | Gene symbol | VMP1 | C17orf64 | Gene ID | 81671 | 124773 |
| Gene name | vacuole membrane protein 1 | chromosome 17 open reading frame 64 | |
| Synonyms | EPG3|TANGO5|TMEM49 | - | |
| Cytomap | 17q23.1 | 17q23.2 | |
| Type of gene | protein-coding | protein-coding | |
| Description | vacuole membrane protein 1ectopic P-granules autophagy protein 3 homologtransmembrane protein 49transport and golgi organization 5 homolog | uncharacterized protein C17orf64 | |
| Modification date | 20180523 | 20180519 | |
| UniProtAcc | Q96GC9 | Q86WR6 | |
| Ensembl transtripts involved in fusion gene | ENST00000262291, ENST00000537567, ENST00000539763, ENST00000536180, ENST00000545362, ENST00000588617, | ENST00000269127, | |
| Fusion gene scores | * DoF score | 19 X 10 X 9=1710 | 6 X 3 X 3=54 |
| # samples | 18 | 6 | |
| ** MAII score | log2(18/1710*10)=-3.24792751344359 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(6/54*10)=0.15200309344505 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | |
| Context | PubMed: VMP1 [Title/Abstract] AND C17orf64 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | LD | BRCA | TCGA-AR-A24R-01A | VMP1 | chr17 | 57851246 | + | C17orf64 | chr17 | 58503144 | + |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| In-frame | ENST00000262291 | ENST00000269127 | VMP1 | chr17 | 57851246 | + | C17orf64 | chr17 | 58503144 | + |
| In-frame | ENST00000537567 | ENST00000269127 | VMP1 | chr17 | 57851246 | + | C17orf64 | chr17 | 58503144 | + |
| In-frame | ENST00000539763 | ENST00000269127 | VMP1 | chr17 | 57851246 | + | C17orf64 | chr17 | 58503144 | + |
| In-frame | ENST00000536180 | ENST00000269127 | VMP1 | chr17 | 57851246 | + | C17orf64 | chr17 | 58503144 | + |
| In-frame | ENST00000545362 | ENST00000269127 | VMP1 | chr17 | 57851246 | + | C17orf64 | chr17 | 58503144 | + |
| intron-3CDS | ENST00000588617 | ENST00000269127 | VMP1 | chr17 | 57851246 | + | C17orf64 | chr17 | 58503144 | + |
Top |
FusionProtFeatures for VMP1_C17orf64 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| VMP1 | C17orf64 |