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Fusion gene ID: 41444 |
FusionGeneSummary for VGLL4_IQSEC1 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: VGLL4_IQSEC1 | Fusion gene ID: 41444 | Hgene | Tgene | Gene symbol | VGLL4 | IQSEC1 | Gene ID | 9686 | 9922 |
| Gene name | vestigial like family member 4 | IQ motif and Sec7 domain 1 | |
| Synonyms | VGL-4 | ARF-GEP100|ARFGEP100|BRAG2|GEP100 | |
| Cytomap | 3p25.3-p25.2 | 3p25.2-p25.1 | |
| Type of gene | protein-coding | protein-coding | |
| Description | transcription cofactor vestigial-like protein 4Vestigial-like 4vestigial like 4 | IQ motif and SEC7 domain-containing protein 1ADP-ribosylation factors guanine nucleotide-exchange protein 100ADP-ribosylation factors guanine nucleotide-exchange protein 2brefeldin A-resistant ARF-GEF2brefeldin-resistant Arf-GEF 2 protein | |
| Modification date | 20180519 | 20180519 | |
| UniProtAcc | Q14135 | Q6DN90 | |
| Ensembl transtripts involved in fusion gene | ENST00000273038, ENST00000430365, ENST00000404339, ENST00000480288, ENST00000413604, ENST00000451674, ENST00000424529, | ENST00000273221, ENST00000473088, | |
| Fusion gene scores | * DoF score | 13 X 10 X 6=780 | 7 X 5 X 3=105 |
| # samples | 17 | 7 | |
| ** MAII score | log2(17/780*10)=-2.19793937761191 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(7/105*10)=-0.584962500721156 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: VGLL4 [Title/Abstract] AND IQSEC1 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | RV | STAD | TCGA-VQ-A92D-01A | VGLL4 | chr3 | 11744445 | - | IQSEC1 | chr3 | 12983365 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| Frame-shift | ENST00000273038 | ENST00000273221 | VGLL4 | chr3 | 11744445 | - | IQSEC1 | chr3 | 12983365 | - |
| 5CDS-5UTR | ENST00000273038 | ENST00000473088 | VGLL4 | chr3 | 11744445 | - | IQSEC1 | chr3 | 12983365 | - |
| intron-3CDS | ENST00000430365 | ENST00000273221 | VGLL4 | chr3 | 11744445 | - | IQSEC1 | chr3 | 12983365 | - |
| intron-5UTR | ENST00000430365 | ENST00000473088 | VGLL4 | chr3 | 11744445 | - | IQSEC1 | chr3 | 12983365 | - |
| 5UTR-3CDS | ENST00000404339 | ENST00000273221 | VGLL4 | chr3 | 11744445 | - | IQSEC1 | chr3 | 12983365 | - |
| 5UTR-5UTR | ENST00000404339 | ENST00000473088 | VGLL4 | chr3 | 11744445 | - | IQSEC1 | chr3 | 12983365 | - |
| intron-3CDS | ENST00000480288 | ENST00000273221 | VGLL4 | chr3 | 11744445 | - | IQSEC1 | chr3 | 12983365 | - |
| intron-5UTR | ENST00000480288 | ENST00000473088 | VGLL4 | chr3 | 11744445 | - | IQSEC1 | chr3 | 12983365 | - |
| intron-3CDS | ENST00000413604 | ENST00000273221 | VGLL4 | chr3 | 11744445 | - | IQSEC1 | chr3 | 12983365 | - |
| intron-5UTR | ENST00000413604 | ENST00000473088 | VGLL4 | chr3 | 11744445 | - | IQSEC1 | chr3 | 12983365 | - |
| intron-3CDS | ENST00000451674 | ENST00000273221 | VGLL4 | chr3 | 11744445 | - | IQSEC1 | chr3 | 12983365 | - |
| intron-5UTR | ENST00000451674 | ENST00000473088 | VGLL4 | chr3 | 11744445 | - | IQSEC1 | chr3 | 12983365 | - |
| intron-3CDS | ENST00000424529 | ENST00000273221 | VGLL4 | chr3 | 11744445 | - | IQSEC1 | chr3 | 12983365 | - |
| intron-5UTR | ENST00000424529 | ENST00000473088 | VGLL4 | chr3 | 11744445 | - | IQSEC1 | chr3 | 12983365 | - |
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FusionProtFeatures for VGLL4_IQSEC1 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| VGLL4 | IQSEC1 |