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Fusion gene ID: 41418 |
FusionGeneSummary for VDR_SLC1A5 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: VDR_SLC1A5 | Fusion gene ID: 41418 | Hgene | Tgene | Gene symbol | VDR | SLC1A5 | Gene ID | 7421 | 6510 |
| Gene name | vitamin D receptor | solute carrier family 1 member 5 | |
| Synonyms | NR1I1|PPP1R163 | AAAT|ASCT2|ATBO|M7V1|M7VS1|R16|RDRC | |
| Cytomap | 12q13.11 | 19q13.32 | |
| Type of gene | protein-coding | protein-coding | |
| Description | vitamin D3 receptor1,25-dihydroxyvitamin D3 receptornuclear receptor subfamily 1 group I member 1protein phosphatase 1, regulatory subunit 163vitamin D (1,25- dihydroxyvitamin D3) receptorvitamin D nuclear receptor variant 1 | neutral amino acid transporter B(0)ATB(0)RD114 virus receptorRD114/simian type D retrovirus receptorbaboon M7 virus receptorneutral amino acid transporter Bsodium-dependent neutral amino acid transporter type 2solute carrier family 1 (neutral amino | |
| Modification date | 20180527 | 20180519 | |
| UniProtAcc | P11473 | Q15758 | |
| Ensembl transtripts involved in fusion gene | ENST00000395324, ENST00000229022, ENST00000549336, ENST00000550325, ENST00000535672, | ENST00000542575, ENST00000434726, ENST00000594991, ENST00000412532, | |
| Fusion gene scores | * DoF score | 2 X 3 X 1=6 | 4 X 4 X 2=32 |
| # samples | 3 | 4 | |
| ** MAII score | log2(3/6*10)=2.32192809488736 | log2(4/32*10)=0.321928094887362 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | |
| Context | PubMed: VDR [Title/Abstract] AND SLC1A5 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | VDR | GO:0000122 | negative regulation of transcription by RNA polymerase II | 17426122 |
| Hgene | VDR | GO:0008285 | negative regulation of cell proliferation | 16549446 |
| Hgene | VDR | GO:0010980 | positive regulation of vitamin D 24-hydroxylase activity | 16549446 |
| Hgene | VDR | GO:0038183 | bile acid signaling pathway | 12016314 |
| Hgene | VDR | GO:0045892 | negative regulation of transcription, DNA-templated | 11891224 |
| Hgene | VDR | GO:0070561 | vitamin D receptor signaling pathway | 16549446 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| ChiTaRS3.1 | BG272237 | VDR | chr12 | 48235575 | + | SLC1A5 | chr19 | 47278590 | + |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| intron-3UTR | ENST00000395324 | ENST00000542575 | VDR | chr12 | 48235575 | + | SLC1A5 | chr19 | 47278590 | + |
| intron-3UTR | ENST00000395324 | ENST00000434726 | VDR | chr12 | 48235575 | + | SLC1A5 | chr19 | 47278590 | + |
| intron-3UTR | ENST00000395324 | ENST00000594991 | VDR | chr12 | 48235575 | + | SLC1A5 | chr19 | 47278590 | + |
| intron-3UTR | ENST00000395324 | ENST00000412532 | VDR | chr12 | 48235575 | + | SLC1A5 | chr19 | 47278590 | + |
| intron-3UTR | ENST00000229022 | ENST00000542575 | VDR | chr12 | 48235575 | + | SLC1A5 | chr19 | 47278590 | + |
| intron-3UTR | ENST00000229022 | ENST00000434726 | VDR | chr12 | 48235575 | + | SLC1A5 | chr19 | 47278590 | + |
| intron-3UTR | ENST00000229022 | ENST00000594991 | VDR | chr12 | 48235575 | + | SLC1A5 | chr19 | 47278590 | + |
| intron-3UTR | ENST00000229022 | ENST00000412532 | VDR | chr12 | 48235575 | + | SLC1A5 | chr19 | 47278590 | + |
| intron-3UTR | ENST00000549336 | ENST00000542575 | VDR | chr12 | 48235575 | + | SLC1A5 | chr19 | 47278590 | + |
| intron-3UTR | ENST00000549336 | ENST00000434726 | VDR | chr12 | 48235575 | + | SLC1A5 | chr19 | 47278590 | + |
| intron-3UTR | ENST00000549336 | ENST00000594991 | VDR | chr12 | 48235575 | + | SLC1A5 | chr19 | 47278590 | + |
| intron-3UTR | ENST00000549336 | ENST00000412532 | VDR | chr12 | 48235575 | + | SLC1A5 | chr19 | 47278590 | + |
| intron-3UTR | ENST00000550325 | ENST00000542575 | VDR | chr12 | 48235575 | + | SLC1A5 | chr19 | 47278590 | + |
| intron-3UTR | ENST00000550325 | ENST00000434726 | VDR | chr12 | 48235575 | + | SLC1A5 | chr19 | 47278590 | + |
| intron-3UTR | ENST00000550325 | ENST00000594991 | VDR | chr12 | 48235575 | + | SLC1A5 | chr19 | 47278590 | + |
| intron-3UTR | ENST00000550325 | ENST00000412532 | VDR | chr12 | 48235575 | + | SLC1A5 | chr19 | 47278590 | + |
| intron-3UTR | ENST00000535672 | ENST00000542575 | VDR | chr12 | 48235575 | + | SLC1A5 | chr19 | 47278590 | + |
| intron-3UTR | ENST00000535672 | ENST00000434726 | VDR | chr12 | 48235575 | + | SLC1A5 | chr19 | 47278590 | + |
| intron-3UTR | ENST00000535672 | ENST00000594991 | VDR | chr12 | 48235575 | + | SLC1A5 | chr19 | 47278590 | + |
| intron-3UTR | ENST00000535672 | ENST00000412532 | VDR | chr12 | 48235575 | + | SLC1A5 | chr19 | 47278590 | + |
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FusionProtFeatures for VDR_SLC1A5 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| VDR | SLC1A5 |