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Fusion gene ID: 41392 |
FusionGeneSummary for VCAN_EDIL3 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: VCAN_EDIL3 | Fusion gene ID: 41392 | Hgene | Tgene | Gene symbol | VCAN | EDIL3 | Gene ID | 1462 | 10085 |
| Gene name | versican | EGF like repeats and discoidin domains 3 | |
| Synonyms | CSPG2|ERVR|GHAP|PG-M|WGN|WGN1 | DEL1 | |
| Cytomap | 5q14.2-q14.3 | 5q14.3 | |
| Type of gene | protein-coding | protein-coding | |
| Description | versican core proteinchondroitin sulfate proteoglycan core protein 2glial hyaluronate-binding proteinlarge fibroblast proteoglycanversican proteoglycan | EGF-like repeat and discoidin I-like domain-containing protein 3EGF-like repeats and discoidin I-like domains 3developmental endothelial locus-1developmentally-regulated endothelial cell locus 1 proteinintegrin-binding protein DEL1 | |
| Modification date | 20180523 | 20180527 | |
| UniProtAcc | P13611 | O43854 | |
| Ensembl transtripts involved in fusion gene | ENST00000265077, ENST00000342785, ENST00000343200, ENST00000512590, ENST00000502527, ENST00000513016, ENST00000513984, | ENST00000296591, ENST00000380138, ENST00000510271, | |
| Fusion gene scores | * DoF score | 3 X 3 X 3=27 | 4 X 4 X 4=64 |
| # samples | 3 | 4 | |
| ** MAII score | log2(3/27*10)=0.15200309344505 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | log2(4/64*10)=-0.678071905112638 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: VCAN [Title/Abstract] AND EDIL3 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | LD | SARC | TCGA-SI-A71Q-01A | VCAN | chr5 | 82789750 | + | EDIL3 | chr5 | 83259179 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| Frame-shift | ENST00000265077 | ENST00000296591 | VCAN | chr5 | 82789750 | + | EDIL3 | chr5 | 83259179 | - |
| Frame-shift | ENST00000265077 | ENST00000380138 | VCAN | chr5 | 82789750 | + | EDIL3 | chr5 | 83259179 | - |
| 5CDS-intron | ENST00000265077 | ENST00000510271 | VCAN | chr5 | 82789750 | + | EDIL3 | chr5 | 83259179 | - |
| Frame-shift | ENST00000342785 | ENST00000296591 | VCAN | chr5 | 82789750 | + | EDIL3 | chr5 | 83259179 | - |
| Frame-shift | ENST00000342785 | ENST00000380138 | VCAN | chr5 | 82789750 | + | EDIL3 | chr5 | 83259179 | - |
| 5CDS-intron | ENST00000342785 | ENST00000510271 | VCAN | chr5 | 82789750 | + | EDIL3 | chr5 | 83259179 | - |
| Frame-shift | ENST00000343200 | ENST00000296591 | VCAN | chr5 | 82789750 | + | EDIL3 | chr5 | 83259179 | - |
| Frame-shift | ENST00000343200 | ENST00000380138 | VCAN | chr5 | 82789750 | + | EDIL3 | chr5 | 83259179 | - |
| 5CDS-intron | ENST00000343200 | ENST00000510271 | VCAN | chr5 | 82789750 | + | EDIL3 | chr5 | 83259179 | - |
| Frame-shift | ENST00000512590 | ENST00000296591 | VCAN | chr5 | 82789750 | + | EDIL3 | chr5 | 83259179 | - |
| Frame-shift | ENST00000512590 | ENST00000380138 | VCAN | chr5 | 82789750 | + | EDIL3 | chr5 | 83259179 | - |
| 5CDS-intron | ENST00000512590 | ENST00000510271 | VCAN | chr5 | 82789750 | + | EDIL3 | chr5 | 83259179 | - |
| Frame-shift | ENST00000502527 | ENST00000296591 | VCAN | chr5 | 82789750 | + | EDIL3 | chr5 | 83259179 | - |
| Frame-shift | ENST00000502527 | ENST00000380138 | VCAN | chr5 | 82789750 | + | EDIL3 | chr5 | 83259179 | - |
| 5CDS-intron | ENST00000502527 | ENST00000510271 | VCAN | chr5 | 82789750 | + | EDIL3 | chr5 | 83259179 | - |
| intron-3CDS | ENST00000513016 | ENST00000296591 | VCAN | chr5 | 82789750 | + | EDIL3 | chr5 | 83259179 | - |
| intron-3CDS | ENST00000513016 | ENST00000380138 | VCAN | chr5 | 82789750 | + | EDIL3 | chr5 | 83259179 | - |
| intron-intron | ENST00000513016 | ENST00000510271 | VCAN | chr5 | 82789750 | + | EDIL3 | chr5 | 83259179 | - |
| Frame-shift | ENST00000513984 | ENST00000296591 | VCAN | chr5 | 82789750 | + | EDIL3 | chr5 | 83259179 | - |
| Frame-shift | ENST00000513984 | ENST00000380138 | VCAN | chr5 | 82789750 | + | EDIL3 | chr5 | 83259179 | - |
| 5CDS-intron | ENST00000513984 | ENST00000510271 | VCAN | chr5 | 82789750 | + | EDIL3 | chr5 | 83259179 | - |
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FusionProtFeatures for VCAN_EDIL3 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| VCAN | EDIL3 |