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Fusion gene ID: 41356 |
FusionGeneSummary for VASN_RBFOX1 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: VASN_RBFOX1 | Fusion gene ID: 41356 | Hgene | Tgene | Gene symbol | VASN | RBFOX1 | Gene ID | 114990 | 54715 |
| Gene name | vasorin | RNA binding fox-1 homolog 1 | |
| Synonyms | SLITL2 | 2BP1|A2BP1|FOX-1|FOX1|HRNBP1 | |
| Cytomap | 16p13.3 | 16p13.3 | |
| Type of gene | protein-coding | protein-coding | |
| Description | vasorinprotein slit-like 2slit-like 2 | RNA binding protein fox-1 homolog 1RNA binding protein, fox-1 homolog 1ataxin 2-binding protein 1fox-1 homolog Afox-1-like RNA-binding protein 1hexaribonucleotide binding protein 1 isoform alphahexaribonucleotide binding protein 1 isoform betahexar | |
| Modification date | 20180523 | 20180523 | |
| UniProtAcc | Q6EMK4 | Q9NWB1 | |
| Ensembl transtripts involved in fusion gene | ENST00000304735, | ENST00000550418, ENST00000553186, ENST00000547372, ENST00000422070, ENST00000535565, ENST00000547427, ENST00000552089, ENST00000547338, ENST00000436368, ENST00000311745, ENST00000355637, ENST00000340209, | |
| Fusion gene scores | * DoF score | 1 X 1 X 1=1 | 14 X 12 X 6=1008 |
| # samples | 1 | 14 | |
| ** MAII score | log2(1/1*10)=3.32192809488736 | log2(14/1008*10)=-2.84799690655495 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: VASN [Title/Abstract] AND RBFOX1 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | VASN | GO:0030512 | negative regulation of transforming growth factor beta receptor signaling pathway | 15247411 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | LD | GBM | TCGA-06-5856-01A | VASN | chr16 | 4421994 | + | RBFOX1 | chr16 | 7759058 | + |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| 5UTR-3CDS | ENST00000304735 | ENST00000550418 | VASN | chr16 | 4421994 | + | RBFOX1 | chr16 | 7759058 | + |
| 5UTR-3CDS | ENST00000304735 | ENST00000553186 | VASN | chr16 | 4421994 | + | RBFOX1 | chr16 | 7759058 | + |
| 5UTR-3CDS | ENST00000304735 | ENST00000547372 | VASN | chr16 | 4421994 | + | RBFOX1 | chr16 | 7759058 | + |
| 5UTR-3CDS | ENST00000304735 | ENST00000422070 | VASN | chr16 | 4421994 | + | RBFOX1 | chr16 | 7759058 | + |
| 5UTR-3CDS | ENST00000304735 | ENST00000535565 | VASN | chr16 | 4421994 | + | RBFOX1 | chr16 | 7759058 | + |
| 5UTR-intron | ENST00000304735 | ENST00000547427 | VASN | chr16 | 4421994 | + | RBFOX1 | chr16 | 7759058 | + |
| 5UTR-intron | ENST00000304735 | ENST00000552089 | VASN | chr16 | 4421994 | + | RBFOX1 | chr16 | 7759058 | + |
| 5UTR-intron | ENST00000304735 | ENST00000547338 | VASN | chr16 | 4421994 | + | RBFOX1 | chr16 | 7759058 | + |
| 5UTR-intron | ENST00000304735 | ENST00000436368 | VASN | chr16 | 4421994 | + | RBFOX1 | chr16 | 7759058 | + |
| 5UTR-intron | ENST00000304735 | ENST00000311745 | VASN | chr16 | 4421994 | + | RBFOX1 | chr16 | 7759058 | + |
| 5UTR-intron | ENST00000304735 | ENST00000355637 | VASN | chr16 | 4421994 | + | RBFOX1 | chr16 | 7759058 | + |
| 5UTR-intron | ENST00000304735 | ENST00000340209 | VASN | chr16 | 4421994 | + | RBFOX1 | chr16 | 7759058 | + |
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FusionProtFeatures for VASN_RBFOX1 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| VASN | RBFOX1 |