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Fusion gene ID: 41355 |
FusionGeneSummary for VASH1_ZNF550 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: VASH1_ZNF550 | Fusion gene ID: 41355 | Hgene | Tgene | Gene symbol | VASH1 | ZNF550 | Gene ID | 22846 | 162972 |
| Gene name | vasohibin 1 | zinc finger protein 550 | |
| Synonyms | KIAA1036 | - | |
| Cytomap | 14q24.3 | 19q13.43 | |
| Type of gene | protein-coding | protein-coding | |
| Description | vasohibin-1 | zinc finger protein 550 | |
| Modification date | 20180523 | 20180523 | |
| UniProtAcc | Q7L8A9 | Q7Z398 | |
| Ensembl transtripts involved in fusion gene | ENST00000167106, ENST00000554237, ENST00000556038, ENST00000554743, | ENST00000601415, ENST00000325134, ENST00000457177, ENST00000506609, | |
| Fusion gene scores | * DoF score | 4 X 4 X 1=16 | 2 X 2 X 2=8 |
| # samples | 4 | 2 | |
| ** MAII score | log2(4/16*10)=1.32192809488736 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | log2(2/8*10)=1.32192809488736 | |
| Context | PubMed: VASH1 [Title/Abstract] AND ZNF550 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | VASH1 | GO:0001525 | angiogenesis | 15467828 |
| Hgene | VASH1 | GO:0001937 | negative regulation of endothelial cell proliferation | 15467828|19204325 |
| Hgene | VASH1 | GO:0009611 | response to wounding | 23056314 |
| Hgene | VASH1 | GO:0016525 | negative regulation of angiogenesis | 15467828 |
| Hgene | VASH1 | GO:0043537 | negative regulation of blood vessel endothelial cell migration | 15467828 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| ChiTaRS3.1 | AA977090 | VASH1 | chr14 | 77248132 | + | ZNF550 | chr19 | 58067569 | + |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| 3UTR-intron | ENST00000167106 | ENST00000601415 | VASH1 | chr14 | 77248132 | + | ZNF550 | chr19 | 58067569 | + |
| 3UTR-intron | ENST00000167106 | ENST00000325134 | VASH1 | chr14 | 77248132 | + | ZNF550 | chr19 | 58067569 | + |
| 3UTR-intron | ENST00000167106 | ENST00000457177 | VASH1 | chr14 | 77248132 | + | ZNF550 | chr19 | 58067569 | + |
| 3UTR-intron | ENST00000167106 | ENST00000506609 | VASH1 | chr14 | 77248132 | + | ZNF550 | chr19 | 58067569 | + |
| intron-intron | ENST00000554237 | ENST00000601415 | VASH1 | chr14 | 77248132 | + | ZNF550 | chr19 | 58067569 | + |
| intron-intron | ENST00000554237 | ENST00000325134 | VASH1 | chr14 | 77248132 | + | ZNF550 | chr19 | 58067569 | + |
| intron-intron | ENST00000554237 | ENST00000457177 | VASH1 | chr14 | 77248132 | + | ZNF550 | chr19 | 58067569 | + |
| intron-intron | ENST00000554237 | ENST00000506609 | VASH1 | chr14 | 77248132 | + | ZNF550 | chr19 | 58067569 | + |
| intron-intron | ENST00000556038 | ENST00000601415 | VASH1 | chr14 | 77248132 | + | ZNF550 | chr19 | 58067569 | + |
| intron-intron | ENST00000556038 | ENST00000325134 | VASH1 | chr14 | 77248132 | + | ZNF550 | chr19 | 58067569 | + |
| intron-intron | ENST00000556038 | ENST00000457177 | VASH1 | chr14 | 77248132 | + | ZNF550 | chr19 | 58067569 | + |
| intron-intron | ENST00000556038 | ENST00000506609 | VASH1 | chr14 | 77248132 | + | ZNF550 | chr19 | 58067569 | + |
| intron-intron | ENST00000554743 | ENST00000601415 | VASH1 | chr14 | 77248132 | + | ZNF550 | chr19 | 58067569 | + |
| intron-intron | ENST00000554743 | ENST00000325134 | VASH1 | chr14 | 77248132 | + | ZNF550 | chr19 | 58067569 | + |
| intron-intron | ENST00000554743 | ENST00000457177 | VASH1 | chr14 | 77248132 | + | ZNF550 | chr19 | 58067569 | + |
| intron-intron | ENST00000554743 | ENST00000506609 | VASH1 | chr14 | 77248132 | + | ZNF550 | chr19 | 58067569 | + |
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FusionProtFeatures for VASH1_ZNF550 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| VASH1 | ZNF550 |