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Fusion gene ID: 41331 |
FusionGeneSummary for VAMP4_MYRFL |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: VAMP4_MYRFL | Fusion gene ID: 41331 | Hgene | Tgene | Gene symbol | VAMP4 | MYRFL | Gene ID | 8674 | 196446 |
| Gene name | vesicle associated membrane protein 4 | myelin regulatory factor like | |
| Synonyms | VAMP-4|VAMP24 | C12orf15|C12orf28|bcm1377 | |
| Cytomap | 1q24.3 | 12q15 | |
| Type of gene | protein-coding | protein-coding | |
| Description | vesicle-associated membrane protein 4VAMP4/TAF3 fusion | myelin regulatory factor-like protein | |
| Modification date | 20180522 | 20180523 | |
| UniProtAcc | O75379 | Q96LU7 | |
| Ensembl transtripts involved in fusion gene | ENST00000236192, ENST00000415773, ENST00000367740, ENST00000482519, | ENST00000552032, ENST00000547771, ENST00000299350, ENST00000535034, | |
| Fusion gene scores | * DoF score | 1 X 1 X 1=1 | 24 X 10 X 4=960 |
| # samples | 1 | 21 | |
| ** MAII score | log2(1/1*10)=3.32192809488736 | log2(21/960*10)=-2.1926450779424 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: VAMP4 [Title/Abstract] AND MYRFL [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | VAMP4 | GO:0035493 | SNARE complex assembly | 21151919 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | LD | SARC | TCGA-FX-A2QS-01A | VAMP4 | chr1 | 171707489 | - | MYRFL | chr12 | 70320351 | + |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| Frame-shift | ENST00000236192 | ENST00000552032 | VAMP4 | chr1 | 171707489 | - | MYRFL | chr12 | 70320351 | + |
| Frame-shift | ENST00000236192 | ENST00000547771 | VAMP4 | chr1 | 171707489 | - | MYRFL | chr12 | 70320351 | + |
| 5CDS-intron | ENST00000236192 | ENST00000299350 | VAMP4 | chr1 | 171707489 | - | MYRFL | chr12 | 70320351 | + |
| 5CDS-intron | ENST00000236192 | ENST00000535034 | VAMP4 | chr1 | 171707489 | - | MYRFL | chr12 | 70320351 | + |
| In-frame | ENST00000415773 | ENST00000552032 | VAMP4 | chr1 | 171707489 | - | MYRFL | chr12 | 70320351 | + |
| In-frame | ENST00000415773 | ENST00000547771 | VAMP4 | chr1 | 171707489 | - | MYRFL | chr12 | 70320351 | + |
| 5CDS-intron | ENST00000415773 | ENST00000299350 | VAMP4 | chr1 | 171707489 | - | MYRFL | chr12 | 70320351 | + |
| 5CDS-intron | ENST00000415773 | ENST00000535034 | VAMP4 | chr1 | 171707489 | - | MYRFL | chr12 | 70320351 | + |
| Frame-shift | ENST00000367740 | ENST00000552032 | VAMP4 | chr1 | 171707489 | - | MYRFL | chr12 | 70320351 | + |
| Frame-shift | ENST00000367740 | ENST00000547771 | VAMP4 | chr1 | 171707489 | - | MYRFL | chr12 | 70320351 | + |
| 5CDS-intron | ENST00000367740 | ENST00000299350 | VAMP4 | chr1 | 171707489 | - | MYRFL | chr12 | 70320351 | + |
| 5CDS-intron | ENST00000367740 | ENST00000535034 | VAMP4 | chr1 | 171707489 | - | MYRFL | chr12 | 70320351 | + |
| 5UTR-3CDS | ENST00000482519 | ENST00000552032 | VAMP4 | chr1 | 171707489 | - | MYRFL | chr12 | 70320351 | + |
| 5UTR-3CDS | ENST00000482519 | ENST00000547771 | VAMP4 | chr1 | 171707489 | - | MYRFL | chr12 | 70320351 | + |
| 5UTR-intron | ENST00000482519 | ENST00000299350 | VAMP4 | chr1 | 171707489 | - | MYRFL | chr12 | 70320351 | + |
| 5UTR-intron | ENST00000482519 | ENST00000535034 | VAMP4 | chr1 | 171707489 | - | MYRFL | chr12 | 70320351 | + |
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FusionProtFeatures for VAMP4_MYRFL |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| VAMP4 | MYRFL |