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Fusion gene ID: 41314 |
FusionGeneSummary for UXS1_C2orf40 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: UXS1_C2orf40 | Fusion gene ID: 41314 | Hgene | Tgene | Gene symbol | UXS1 | C2orf40 | Gene ID | 80146 | 84417 |
| Gene name | UDP-glucuronate decarboxylase 1 | chromosome 2 open reading frame 40 | |
| Synonyms | SDR6E1|UGD | ECRG4 | |
| Cytomap | 2q12.2 | 2q12.2 | |
| Type of gene | protein-coding | protein-coding | |
| Description | UDP-glucuronic acid decarboxylase 1UXS-1short chain dehydrogenase/reductase family 6E, member 12 | augurinesophageal cancer related gene 4 protein | |
| Modification date | 20180523 | 20180519 | |
| UniProtAcc | Q8NBZ7 | Q9H1Z8 | |
| Ensembl transtripts involved in fusion gene | ENST00000283148, ENST00000540130, ENST00000409501, ENST00000409032, ENST00000428048, ENST00000479621, | ENST00000409944, ENST00000238044, ENST00000489174, | |
| Fusion gene scores | * DoF score | 4 X 4 X 3=48 | 1 X 1 X 1=1 |
| # samples | 4 | 1 | |
| ** MAII score | log2(4/48*10)=-0.263034405833794 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(1/1*10)=3.32192809488736 | |
| Context | PubMed: UXS1 [Title/Abstract] AND C2orf40 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | UXS1 | GO:0051262 | protein tetramerization | 23656592 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | RV | BLCA | TCGA-G2-AA3F-01A | UXS1 | chr2 | 106746130 | - | C2orf40 | chr2 | 106688300 | + |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| 5CDS-5UTR | ENST00000283148 | ENST00000409944 | UXS1 | chr2 | 106746130 | - | C2orf40 | chr2 | 106688300 | + |
| 5CDS-5UTR | ENST00000283148 | ENST00000238044 | UXS1 | chr2 | 106746130 | - | C2orf40 | chr2 | 106688300 | + |
| 5CDS-3UTR | ENST00000283148 | ENST00000489174 | UXS1 | chr2 | 106746130 | - | C2orf40 | chr2 | 106688300 | + |
| 5CDS-5UTR | ENST00000540130 | ENST00000409944 | UXS1 | chr2 | 106746130 | - | C2orf40 | chr2 | 106688300 | + |
| 5CDS-5UTR | ENST00000540130 | ENST00000238044 | UXS1 | chr2 | 106746130 | - | C2orf40 | chr2 | 106688300 | + |
| 5CDS-3UTR | ENST00000540130 | ENST00000489174 | UXS1 | chr2 | 106746130 | - | C2orf40 | chr2 | 106688300 | + |
| 5CDS-5UTR | ENST00000409501 | ENST00000409944 | UXS1 | chr2 | 106746130 | - | C2orf40 | chr2 | 106688300 | + |
| 5CDS-5UTR | ENST00000409501 | ENST00000238044 | UXS1 | chr2 | 106746130 | - | C2orf40 | chr2 | 106688300 | + |
| 5CDS-3UTR | ENST00000409501 | ENST00000489174 | UXS1 | chr2 | 106746130 | - | C2orf40 | chr2 | 106688300 | + |
| 5CDS-5UTR | ENST00000409032 | ENST00000409944 | UXS1 | chr2 | 106746130 | - | C2orf40 | chr2 | 106688300 | + |
| 5CDS-5UTR | ENST00000409032 | ENST00000238044 | UXS1 | chr2 | 106746130 | - | C2orf40 | chr2 | 106688300 | + |
| 5CDS-3UTR | ENST00000409032 | ENST00000489174 | UXS1 | chr2 | 106746130 | - | C2orf40 | chr2 | 106688300 | + |
| intron-5UTR | ENST00000428048 | ENST00000409944 | UXS1 | chr2 | 106746130 | - | C2orf40 | chr2 | 106688300 | + |
| intron-5UTR | ENST00000428048 | ENST00000238044 | UXS1 | chr2 | 106746130 | - | C2orf40 | chr2 | 106688300 | + |
| intron-3UTR | ENST00000428048 | ENST00000489174 | UXS1 | chr2 | 106746130 | - | C2orf40 | chr2 | 106688300 | + |
| intron-5UTR | ENST00000479621 | ENST00000409944 | UXS1 | chr2 | 106746130 | - | C2orf40 | chr2 | 106688300 | + |
| intron-5UTR | ENST00000479621 | ENST00000238044 | UXS1 | chr2 | 106746130 | - | C2orf40 | chr2 | 106688300 | + |
| intron-3UTR | ENST00000479621 | ENST00000489174 | UXS1 | chr2 | 106746130 | - | C2orf40 | chr2 | 106688300 | + |
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FusionProtFeatures for UXS1_C2orf40 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| UXS1 | C2orf40 |