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Fusion gene ID: 41292 |
FusionGeneSummary for UVRAG_KCTD14 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: UVRAG_KCTD14 | Fusion gene ID: 41292 | Hgene | Tgene | Gene symbol | UVRAG | KCTD14 | Gene ID | 7405 | 65987 |
| Gene name | UV radiation resistance associated | potassium channel tetramerization domain containing 14 | |
| Synonyms | DHTX|VPS38|p63 | - | |
| Cytomap | 11q13.5 | 11q14.1 | |
| Type of gene | protein-coding | protein-coding | |
| Description | UV radiation resistance-associated gene proteinbeclin 1 binding proteindisrupted in heterotaxy | BTB/POZ domain-containing protein KCTD14potassium channel tetramerisation domain containing 14 | |
| Modification date | 20180523 | 20180519 | |
| UniProtAcc | Q9P2Y5 | Q9BQ13 | |
| Ensembl transtripts involved in fusion gene | ENST00000356136, ENST00000528420, ENST00000533454, ENST00000531818, ENST00000532130, ENST00000539288, ENST00000525872, ENST00000538870, | ENST00000353172, ENST00000533144, | |
| Fusion gene scores | * DoF score | 29 X 10 X 12=3480 | 5 X 3 X 3=45 |
| # samples | 29 | 5 | |
| ** MAII score | log2(29/3480*10)=-3.58496250072116 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(5/45*10)=0.15200309344505 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | |
| Context | PubMed: UVRAG [Title/Abstract] AND KCTD14 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | Tumor suppressor gene involved fusion gene, in-frame but not retained their domain. | ||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | UVRAG | GO:0071900 | regulation of protein serine/threonine kinase activity | 22542840 |
| Hgene | UVRAG | GO:0097680 | double-strand break repair via classical nonhomologous end joining | 22542840 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | LD | BRCA | TCGA-BH-A0BD-01A | UVRAG | chr11 | 75776832 | + | KCTD14 | chr11 | 77728316 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| In-frame | ENST00000356136 | ENST00000353172 | UVRAG | chr11 | 75776832 | + | KCTD14 | chr11 | 77728316 | - |
| Frame-shift | ENST00000356136 | ENST00000533144 | UVRAG | chr11 | 75776832 | + | KCTD14 | chr11 | 77728316 | - |
| In-frame | ENST00000528420 | ENST00000353172 | UVRAG | chr11 | 75776832 | + | KCTD14 | chr11 | 77728316 | - |
| Frame-shift | ENST00000528420 | ENST00000533144 | UVRAG | chr11 | 75776832 | + | KCTD14 | chr11 | 77728316 | - |
| In-frame | ENST00000533454 | ENST00000353172 | UVRAG | chr11 | 75776832 | + | KCTD14 | chr11 | 77728316 | - |
| Frame-shift | ENST00000533454 | ENST00000533144 | UVRAG | chr11 | 75776832 | + | KCTD14 | chr11 | 77728316 | - |
| In-frame | ENST00000531818 | ENST00000353172 | UVRAG | chr11 | 75776832 | + | KCTD14 | chr11 | 77728316 | - |
| Frame-shift | ENST00000531818 | ENST00000533144 | UVRAG | chr11 | 75776832 | + | KCTD14 | chr11 | 77728316 | - |
| In-frame | ENST00000532130 | ENST00000353172 | UVRAG | chr11 | 75776832 | + | KCTD14 | chr11 | 77728316 | - |
| Frame-shift | ENST00000532130 | ENST00000533144 | UVRAG | chr11 | 75776832 | + | KCTD14 | chr11 | 77728316 | - |
| In-frame | ENST00000539288 | ENST00000353172 | UVRAG | chr11 | 75776832 | + | KCTD14 | chr11 | 77728316 | - |
| Frame-shift | ENST00000539288 | ENST00000533144 | UVRAG | chr11 | 75776832 | + | KCTD14 | chr11 | 77728316 | - |
| intron-3CDS | ENST00000525872 | ENST00000353172 | UVRAG | chr11 | 75776832 | + | KCTD14 | chr11 | 77728316 | - |
| intron-3CDS | ENST00000525872 | ENST00000533144 | UVRAG | chr11 | 75776832 | + | KCTD14 | chr11 | 77728316 | - |
| intron-3CDS | ENST00000538870 | ENST00000353172 | UVRAG | chr11 | 75776832 | + | KCTD14 | chr11 | 77728316 | - |
| intron-3CDS | ENST00000538870 | ENST00000533144 | UVRAG | chr11 | 75776832 | + | KCTD14 | chr11 | 77728316 | - |
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FusionProtFeatures for UVRAG_KCTD14 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| UVRAG | KCTD14 |