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Fusion gene ID: 41234 |
FusionGeneSummary for UST_CCDC6 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: UST_CCDC6 | Fusion gene ID: 41234 | Hgene | Tgene | Gene symbol | UST | CCDC6 | Gene ID | 10090 | 8030 |
| Gene name | uronyl 2-sulfotransferase | coiled-coil domain containing 6 | |
| Synonyms | 2OST | D10S170|H4|PTC|TPC|TST1 | |
| Cytomap | 6q25.1 | 10q21.2 | |
| Type of gene | protein-coding | protein-coding | |
| Description | uronyl 2-sulfotransferasedermatan/chondroitin sulfate 2-sulfotransferase | coiled-coil domain-containing protein 6papillary thyroid carcinoma-encoded protein | |
| Modification date | 20180523 | 20180522 | |
| UniProtAcc | Q9Y2C2 | Q16204 | |
| Ensembl transtripts involved in fusion gene | ENST00000367463, ENST00000466695, | ENST00000263102, | |
| Fusion gene scores | * DoF score | 8 X 6 X 4=192 | 8 X 5 X 5=200 |
| # samples | 8 | 9 | |
| ** MAII score | log2(8/192*10)=-1.26303440583379 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(9/200*10)=-1.15200309344505 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: UST [Title/Abstract] AND CCDC6 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | LD | THCA | TCGA-CE-A13K-01A | UST | chr6 | 149342617 | + | CCDC6 | chr10 | 61552867 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| Frame-shift | ENST00000367463 | ENST00000263102 | UST | chr6 | 149342617 | + | CCDC6 | chr10 | 61552867 | - |
| intron-3CDS | ENST00000466695 | ENST00000263102 | UST | chr6 | 149342617 | + | CCDC6 | chr10 | 61552867 | - |
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FusionProtFeatures for UST_CCDC6 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| UST | CCDC6 |