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Fusion gene ID: 41229 |
FusionGeneSummary for USPL1_ANKRD7 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: USPL1_ANKRD7 | Fusion gene ID: 41229 | Hgene | Tgene | Gene symbol | USPL1 | ANKRD7 | Gene ID | 10208 | 56311 |
| Gene name | ubiquitin specific peptidase like 1 | ankyrin repeat domain 7 | |
| Synonyms | C13orf22|D13S106E|bA121O19.1 | TSA806 | |
| Cytomap | 13q12.3 | 7q31.31 | |
| Type of gene | protein-coding | protein-coding | |
| Description | SUMO-specific isopeptidase USPL1USP-like 1highly charged proteinubiquitin-specific peptidase-like protein 1 | ankyrin repeat domain-containing protein 7testicular tissue protein Li 19testis-specific ankyrin motif containing proteintestis-specific protein TSA806 | |
| Modification date | 20180519 | 20180519 | |
| UniProtAcc | Q5W0Q7 | Q92527 | |
| Ensembl transtripts involved in fusion gene | ENST00000465952, ENST00000255304, | ENST00000477532, ENST00000357099, ENST00000265224, ENST00000417525, ENST00000433239, | |
| Fusion gene scores | * DoF score | 3 X 2 X 3=18 | 2 X 2 X 2=8 |
| # samples | 3 | 2 | |
| ** MAII score | log2(3/18*10)=0.736965594166206 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | log2(2/8*10)=1.32192809488736 | |
| Context | PubMed: USPL1 [Title/Abstract] AND ANKRD7 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | USPL1 | GO:0016926 | protein desumoylation | 22878415 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | LD | PRAD | TCGA-XQ-A8TA-01A | USPL1 | chr13 | 31192193 | + | ANKRD7 | chr7 | 117899891 | + |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| 3UTR-intron | ENST00000465952 | ENST00000477532 | USPL1 | chr13 | 31192193 | + | ANKRD7 | chr7 | 117899891 | + |
| 3UTR-intron | ENST00000465952 | ENST00000357099 | USPL1 | chr13 | 31192193 | + | ANKRD7 | chr7 | 117899891 | + |
| 3UTR-intron | ENST00000465952 | ENST00000265224 | USPL1 | chr13 | 31192193 | + | ANKRD7 | chr7 | 117899891 | + |
| 3UTR-intron | ENST00000465952 | ENST00000417525 | USPL1 | chr13 | 31192193 | + | ANKRD7 | chr7 | 117899891 | + |
| 3UTR-intron | ENST00000465952 | ENST00000433239 | USPL1 | chr13 | 31192193 | + | ANKRD7 | chr7 | 117899891 | + |
| 5UTR-intron | ENST00000255304 | ENST00000477532 | USPL1 | chr13 | 31192193 | + | ANKRD7 | chr7 | 117899891 | + |
| 5UTR-intron | ENST00000255304 | ENST00000357099 | USPL1 | chr13 | 31192193 | + | ANKRD7 | chr7 | 117899891 | + |
| 5UTR-intron | ENST00000255304 | ENST00000265224 | USPL1 | chr13 | 31192193 | + | ANKRD7 | chr7 | 117899891 | + |
| 5UTR-intron | ENST00000255304 | ENST00000417525 | USPL1 | chr13 | 31192193 | + | ANKRD7 | chr7 | 117899891 | + |
| 5UTR-intron | ENST00000255304 | ENST00000433239 | USPL1 | chr13 | 31192193 | + | ANKRD7 | chr7 | 117899891 | + |
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FusionProtFeatures for USPL1_ANKRD7 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| USPL1 | ANKRD7 |