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Fusion gene ID: 41220 |
FusionGeneSummary for USP9X_KDM6A |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: USP9X_KDM6A | Fusion gene ID: 41220 | Hgene | Tgene | Gene symbol | USP9X | KDM6A | Gene ID | 8239 | 7403 |
| Gene name | ubiquitin specific peptidase 9 X-linked | lysine demethylase 6A | |
| Synonyms | DFFRX|FAF|FAM|MRX99|MRXS99F | KABUK2|UTX|bA386N14.2 | |
| Cytomap | Xp11.4 | Xp11.3 | |
| Type of gene | protein-coding | protein-coding | |
| Description | probable ubiquitin carboxyl-terminal hydrolase FAF-XDrosophila fat facets related, X-linkeddeubiquitinating enzyme FAF-Xfat facets in mammalsfat facets protein related, X-linkedhFAMubiquitin specific protease 9, X chromosome (fat facets-like Drosoph | lysine-specific demethylase 6AbA386N14.2 (ubiquitously transcribed X chromosome tetratricopeptide repeat protein (UTX))histone demethylase UTXlysine (K)-specific demethylase 6Aubiquitously transcribed tetratricopeptide repeat protein X-linkedubiquito | |
| Modification date | 20180523 | 20180523 | |
| UniProtAcc | Q93008 | O15550 | |
| Ensembl transtripts involved in fusion gene | ENST00000378308, ENST00000324545, | ENST00000377967, ENST00000382899, ENST00000536777, ENST00000543216, ENST00000479423, | |
| Fusion gene scores | * DoF score | 14 X 8 X 10=1120 | 5 X 5 X 5=125 |
| # samples | 15 | 5 | |
| ** MAII score | log2(15/1120*10)=-2.90046432644909 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(5/125*10)=-1.32192809488736 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: USP9X [Title/Abstract] AND KDM6A [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | USP9X | GO:0016579 | protein deubiquitination | 19135894 |
| Hgene | USP9X | GO:0030509 | BMP signaling pathway | 19135894 |
| Hgene | USP9X | GO:1901537 | positive regulation of DNA demethylation | 25944111 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | RV | LUAD | TCGA-86-7954-01A | USP9X | chrX | 41031211 | + | KDM6A | chrX | 44870206 | + |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| Frame-shift | ENST00000378308 | ENST00000377967 | USP9X | chrX | 41031211 | + | KDM6A | chrX | 44870206 | + |
| Frame-shift | ENST00000378308 | ENST00000382899 | USP9X | chrX | 41031211 | + | KDM6A | chrX | 44870206 | + |
| Frame-shift | ENST00000378308 | ENST00000536777 | USP9X | chrX | 41031211 | + | KDM6A | chrX | 44870206 | + |
| Frame-shift | ENST00000378308 | ENST00000543216 | USP9X | chrX | 41031211 | + | KDM6A | chrX | 44870206 | + |
| 5CDS-intron | ENST00000378308 | ENST00000479423 | USP9X | chrX | 41031211 | + | KDM6A | chrX | 44870206 | + |
| Frame-shift | ENST00000324545 | ENST00000377967 | USP9X | chrX | 41031211 | + | KDM6A | chrX | 44870206 | + |
| Frame-shift | ENST00000324545 | ENST00000382899 | USP9X | chrX | 41031211 | + | KDM6A | chrX | 44870206 | + |
| Frame-shift | ENST00000324545 | ENST00000536777 | USP9X | chrX | 41031211 | + | KDM6A | chrX | 44870206 | + |
| Frame-shift | ENST00000324545 | ENST00000543216 | USP9X | chrX | 41031211 | + | KDM6A | chrX | 44870206 | + |
| 5CDS-intron | ENST00000324545 | ENST00000479423 | USP9X | chrX | 41031211 | + | KDM6A | chrX | 44870206 | + |
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FusionProtFeatures for USP9X_KDM6A |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| USP9X | KDM6A |