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Fusion gene ID: 41208 |
FusionGeneSummary for USP8_BDP1 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: USP8_BDP1 | Fusion gene ID: 41208 | Hgene | Tgene | Gene symbol | USP8 | BDP1 | Gene ID | 9101 | 55814 |
| Gene name | ubiquitin specific peptidase 8 | B double prime 1, subunit of RNA polymerase III transcription initiation factor IIIB | |
| Synonyms | HumORF8|PITA4|SPG59|UBPY | HSA238520|TAF3B1|TFC5|TFIIIB''|TFIIIB150|TFIIIB90|TFNR | |
| Cytomap | 15q21.2 | 5q13.2 | |
| Type of gene | protein-coding | protein-coding | |
| Description | ubiquitin carboxyl-terminal hydrolase 8deubiquitinating enzyme 8ubiquitin isopeptidase Yubiquitin thiolesterase 8ubiquitin-specific-processing protease 8 | transcription factor TFIIIB component B'' homologRNA polymerase III transcription initiation factor B''TATA box binding protein (TBP)-associated factor, RNA polymerase III, GTF3B subunit 1transcription factor IIIB 150transcription factor-like nuclear | |
| Modification date | 20180527 | 20180523 | |
| UniProtAcc | P40818 | A6H8Y1 | |
| Ensembl transtripts involved in fusion gene | ENST00000307179, ENST00000433963, ENST00000396444, ENST00000425032, ENST00000558892, | ENST00000358731, ENST00000380675, | |
| Fusion gene scores | * DoF score | 8 X 8 X 7=448 | 3 X 4 X 3=36 |
| # samples | 9 | 4 | |
| ** MAII score | log2(9/448*10)=-2.31550182572793 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(4/36*10)=0.15200309344505 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | |
| Context | PubMed: USP8 [Title/Abstract] AND BDP1 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | USP8 | GO:0070536 | protein K63-linked deubiquitination | 16520378 |
| Hgene | USP8 | GO:0071108 | protein K48-linked deubiquitination | 16520378 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | RV | SKCM | TCGA-BF-A5EQ-01A | USP8 | chr15 | 50769696 | + | BDP1 | chr5 | 70786811 | + |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| Frame-shift | ENST00000307179 | ENST00000358731 | USP8 | chr15 | 50769696 | + | BDP1 | chr5 | 70786811 | + |
| 5CDS-5UTR | ENST00000307179 | ENST00000380675 | USP8 | chr15 | 50769696 | + | BDP1 | chr5 | 70786811 | + |
| Frame-shift | ENST00000433963 | ENST00000358731 | USP8 | chr15 | 50769696 | + | BDP1 | chr5 | 70786811 | + |
| 5CDS-5UTR | ENST00000433963 | ENST00000380675 | USP8 | chr15 | 50769696 | + | BDP1 | chr5 | 70786811 | + |
| Frame-shift | ENST00000396444 | ENST00000358731 | USP8 | chr15 | 50769696 | + | BDP1 | chr5 | 70786811 | + |
| 5CDS-5UTR | ENST00000396444 | ENST00000380675 | USP8 | chr15 | 50769696 | + | BDP1 | chr5 | 70786811 | + |
| Frame-shift | ENST00000425032 | ENST00000358731 | USP8 | chr15 | 50769696 | + | BDP1 | chr5 | 70786811 | + |
| 5CDS-5UTR | ENST00000425032 | ENST00000380675 | USP8 | chr15 | 50769696 | + | BDP1 | chr5 | 70786811 | + |
| intron-3CDS | ENST00000558892 | ENST00000358731 | USP8 | chr15 | 50769696 | + | BDP1 | chr5 | 70786811 | + |
| intron-5UTR | ENST00000558892 | ENST00000380675 | USP8 | chr15 | 50769696 | + | BDP1 | chr5 | 70786811 | + |
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FusionProtFeatures for USP8_BDP1 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| USP8 | BDP1 |