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Fusion gene ID: 4120 |
FusionGeneSummary for BEST3_CCT2 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: BEST3_CCT2 | Fusion gene ID: 4120 | Hgene | Tgene | Gene symbol | BEST3 | CCT2 | Gene ID | 144453 | 10576 |
| Gene name | bestrophin 3 | chaperonin containing TCP1 subunit 2 | |
| Synonyms | VMD2L3 | 99D8.1|CCT-beta|CCTB|HEL-S-100n|PRO1633|TCP-1-beta | |
| Cytomap | 12q15 | 12q15 | |
| Type of gene | protein-coding | protein-coding | |
| Description | bestrophin-3vitelliform macular dystrophy 2-like 3vitelliform macular dystrophy 2-like protein 3 | T-complex protein 1 subunit betaT-complex protein 1, beta subunitchaperonin containing TCP1, subunit 2 (beta)chaperonin containing t-complex polypeptide 1, beta subunitchaperonin containing t-complex polypeptide 1, subunit 2epididymis secretory sperm | |
| Modification date | 20180523 | 20180523 | |
| UniProtAcc | Q8N1M1 | P78371 | |
| Ensembl transtripts involved in fusion gene | ENST00000331471, ENST00000488961, ENST00000330891, ENST00000553096, ENST00000476098, ENST00000266661, ENST00000551160, ENST00000393365, ENST00000533674, | ENST00000299300, ENST00000544368, ENST00000543146, | |
| Fusion gene scores | * DoF score | 3 X 3 X 1=9 | 10 X 8 X 5=400 |
| # samples | 3 | 10 | |
| ** MAII score | log2(3/9*10)=1.73696559416621 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | log2(10/400*10)=-2 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: BEST3 [Title/Abstract] AND CCT2 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | LD | SARC | TCGA-3B-A9HS-01A | BEST3 | chr12 | 70037469 | - | CCT2 | chr12 | 69995075 | + |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| intron-3CDS | ENST00000331471 | ENST00000299300 | BEST3 | chr12 | 70037469 | - | CCT2 | chr12 | 69995075 | + |
| intron-3CDS | ENST00000331471 | ENST00000544368 | BEST3 | chr12 | 70037469 | - | CCT2 | chr12 | 69995075 | + |
| intron-3CDS | ENST00000331471 | ENST00000543146 | BEST3 | chr12 | 70037469 | - | CCT2 | chr12 | 69995075 | + |
| intron-3CDS | ENST00000488961 | ENST00000299300 | BEST3 | chr12 | 70037469 | - | CCT2 | chr12 | 69995075 | + |
| intron-3CDS | ENST00000488961 | ENST00000544368 | BEST3 | chr12 | 70037469 | - | CCT2 | chr12 | 69995075 | + |
| intron-3CDS | ENST00000488961 | ENST00000543146 | BEST3 | chr12 | 70037469 | - | CCT2 | chr12 | 69995075 | + |
| intron-3CDS | ENST00000330891 | ENST00000299300 | BEST3 | chr12 | 70037469 | - | CCT2 | chr12 | 69995075 | + |
| intron-3CDS | ENST00000330891 | ENST00000544368 | BEST3 | chr12 | 70037469 | - | CCT2 | chr12 | 69995075 | + |
| intron-3CDS | ENST00000330891 | ENST00000543146 | BEST3 | chr12 | 70037469 | - | CCT2 | chr12 | 69995075 | + |
| intron-3CDS | ENST00000553096 | ENST00000299300 | BEST3 | chr12 | 70037469 | - | CCT2 | chr12 | 69995075 | + |
| intron-3CDS | ENST00000553096 | ENST00000544368 | BEST3 | chr12 | 70037469 | - | CCT2 | chr12 | 69995075 | + |
| intron-3CDS | ENST00000553096 | ENST00000543146 | BEST3 | chr12 | 70037469 | - | CCT2 | chr12 | 69995075 | + |
| intron-3CDS | ENST00000476098 | ENST00000299300 | BEST3 | chr12 | 70037469 | - | CCT2 | chr12 | 69995075 | + |
| intron-3CDS | ENST00000476098 | ENST00000544368 | BEST3 | chr12 | 70037469 | - | CCT2 | chr12 | 69995075 | + |
| intron-3CDS | ENST00000476098 | ENST00000543146 | BEST3 | chr12 | 70037469 | - | CCT2 | chr12 | 69995075 | + |
| intron-3CDS | ENST00000266661 | ENST00000299300 | BEST3 | chr12 | 70037469 | - | CCT2 | chr12 | 69995075 | + |
| intron-3CDS | ENST00000266661 | ENST00000544368 | BEST3 | chr12 | 70037469 | - | CCT2 | chr12 | 69995075 | + |
| intron-3CDS | ENST00000266661 | ENST00000543146 | BEST3 | chr12 | 70037469 | - | CCT2 | chr12 | 69995075 | + |
| intron-3CDS | ENST00000551160 | ENST00000299300 | BEST3 | chr12 | 70037469 | - | CCT2 | chr12 | 69995075 | + |
| intron-3CDS | ENST00000551160 | ENST00000544368 | BEST3 | chr12 | 70037469 | - | CCT2 | chr12 | 69995075 | + |
| intron-3CDS | ENST00000551160 | ENST00000543146 | BEST3 | chr12 | 70037469 | - | CCT2 | chr12 | 69995075 | + |
| intron-3CDS | ENST00000393365 | ENST00000299300 | BEST3 | chr12 | 70037469 | - | CCT2 | chr12 | 69995075 | + |
| intron-3CDS | ENST00000393365 | ENST00000544368 | BEST3 | chr12 | 70037469 | - | CCT2 | chr12 | 69995075 | + |
| intron-3CDS | ENST00000393365 | ENST00000543146 | BEST3 | chr12 | 70037469 | - | CCT2 | chr12 | 69995075 | + |
| intron-3CDS | ENST00000533674 | ENST00000299300 | BEST3 | chr12 | 70037469 | - | CCT2 | chr12 | 69995075 | + |
| intron-3CDS | ENST00000533674 | ENST00000544368 | BEST3 | chr12 | 70037469 | - | CCT2 | chr12 | 69995075 | + |
| intron-3CDS | ENST00000533674 | ENST00000543146 | BEST3 | chr12 | 70037469 | - | CCT2 | chr12 | 69995075 | + |
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FusionProtFeatures for BEST3_CCT2 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| BEST3 | CCT2 |