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Fusion gene ID: 4119 |
FusionGeneSummary for BEND7_PHYH |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: BEND7_PHYH | Fusion gene ID: 4119 | Hgene | Tgene | Gene symbol | BEND7 | PHYH | Gene ID | 222389 | 5264 |
| Gene name | BEN domain containing 7 | phytanoyl-CoA 2-hydroxylase | |
| Synonyms | C10orf30 | LN1|LNAP1|PAHX|PHYH1|RD | |
| Cytomap | 10p13 | 10p13 | |
| Type of gene | protein-coding | protein-coding | |
| Description | BEN domain-containing protein 7 | phytanoyl-CoA dioxygenase, peroxisomalphytanic acid oxidasephytanoil-CoA alpha hydroxylasephytanoyl-CoA 2 oxoglutarate dioxygenasephytanoyl-CoA alpha-hydroxylase | |
| Modification date | 20180519 | 20180523 | |
| UniProtAcc | Q8N7W2 | O14832 | |
| Ensembl transtripts involved in fusion gene | ENST00000486542, ENST00000396900, ENST00000341083, ENST00000396898, ENST00000378605, | ENST00000396913, ENST00000263038, ENST00000396920, | |
| Fusion gene scores | * DoF score | 2 X 2 X 2=8 | 1 X 1 X 1=1 |
| # samples | 3 | 1 | |
| ** MAII score | log2(3/8*10)=1.90689059560852 | log2(1/1*10)=3.32192809488736 | |
| Context | PubMed: BEND7 [Title/Abstract] AND PHYH [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Tgene | PHYH | GO:0001561 | fatty acid alpha-oxidation | 9326939|16186124 |
| Tgene | PHYH | GO:0006103 | 2-oxoglutarate metabolic process | 16186124 |
| Tgene | PHYH | GO:0006720 | isoprenoid metabolic process | 11555634 |
| Tgene | PHYH | GO:0097089 | methyl-branched fatty acid metabolic process | 10744784 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | LD | OV | TCGA-25-2393-01A | BEND7 | chr10 | 13568138 | - | PHYH | chr10 | 13323110 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| intron-3CDS | ENST00000486542 | ENST00000396913 | BEND7 | chr10 | 13568138 | - | PHYH | chr10 | 13323110 | - |
| intron-3CDS | ENST00000486542 | ENST00000263038 | BEND7 | chr10 | 13568138 | - | PHYH | chr10 | 13323110 | - |
| intron-3CDS | ENST00000486542 | ENST00000396920 | BEND7 | chr10 | 13568138 | - | PHYH | chr10 | 13323110 | - |
| Frame-shift | ENST00000396900 | ENST00000396913 | BEND7 | chr10 | 13568138 | - | PHYH | chr10 | 13323110 | - |
| Frame-shift | ENST00000396900 | ENST00000263038 | BEND7 | chr10 | 13568138 | - | PHYH | chr10 | 13323110 | - |
| Frame-shift | ENST00000396900 | ENST00000396920 | BEND7 | chr10 | 13568138 | - | PHYH | chr10 | 13323110 | - |
| intron-3CDS | ENST00000341083 | ENST00000396913 | BEND7 | chr10 | 13568138 | - | PHYH | chr10 | 13323110 | - |
| intron-3CDS | ENST00000341083 | ENST00000263038 | BEND7 | chr10 | 13568138 | - | PHYH | chr10 | 13323110 | - |
| intron-3CDS | ENST00000341083 | ENST00000396920 | BEND7 | chr10 | 13568138 | - | PHYH | chr10 | 13323110 | - |
| Frame-shift | ENST00000396898 | ENST00000396913 | BEND7 | chr10 | 13568138 | - | PHYH | chr10 | 13323110 | - |
| Frame-shift | ENST00000396898 | ENST00000263038 | BEND7 | chr10 | 13568138 | - | PHYH | chr10 | 13323110 | - |
| Frame-shift | ENST00000396898 | ENST00000396920 | BEND7 | chr10 | 13568138 | - | PHYH | chr10 | 13323110 | - |
| intron-3CDS | ENST00000378605 | ENST00000396913 | BEND7 | chr10 | 13568138 | - | PHYH | chr10 | 13323110 | - |
| intron-3CDS | ENST00000378605 | ENST00000263038 | BEND7 | chr10 | 13568138 | - | PHYH | chr10 | 13323110 | - |
| intron-3CDS | ENST00000378605 | ENST00000396920 | BEND7 | chr10 | 13568138 | - | PHYH | chr10 | 13323110 | - |
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FusionProtFeatures for BEND7_PHYH |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| BEND7 | PHYH |