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Fusion gene ID: 4110 |
FusionGeneSummary for BDP1_FAM172A |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: BDP1_FAM172A | Fusion gene ID: 4110 | Hgene | Tgene | Gene symbol | BDP1 | FAM172A | Gene ID | 55814 | 83989 |
| Gene name | B double prime 1, subunit of RNA polymerase III transcription initiation factor IIIB | family with sequence similarity 172 member A | |
| Synonyms | HSA238520|TAF3B1|TFC5|TFIIIB''|TFIIIB150|TFIIIB90|TFNR | C5orf21 | |
| Cytomap | 5q13.2 | 5q15 | |
| Type of gene | protein-coding | protein-coding | |
| Description | transcription factor TFIIIB component B'' homologRNA polymerase III transcription initiation factor B''TATA box binding protein (TBP)-associated factor, RNA polymerase III, GTF3B subunit 1transcription factor IIIB 150transcription factor-like nuclear | protein FAM172A | |
| Modification date | 20180523 | 20180523 | |
| UniProtAcc | A6H8Y1 | Q8WUF8 | |
| Ensembl transtripts involved in fusion gene | ENST00000358731, ENST00000380675, | ENST00000395965, ENST00000505869, ENST00000509739, ENST00000509163, ENST00000504768, | |
| Fusion gene scores | * DoF score | 4 X 5 X 3=60 | 4 X 4 X 3=48 |
| # samples | 6 | 4 | |
| ** MAII score | log2(6/60*10)=0 | log2(4/48*10)=-0.263034405833794 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: BDP1 [Title/Abstract] AND FAM172A [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | Tumor suppressor gene involved fusion gene, in-frame but not retained their domain. Tumor suppressor gene involved fusion gene, retained protein feature but frameshift. DDR (DNA damage repair) gene involved fusion gene, in-frame but not retained their domain. | ||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | RV | LIHC | TCGA-DD-AADB-01A | BDP1 | chr5 | 70828254 | + | FAM172A | chr5 | 93217394 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| In-frame | ENST00000358731 | ENST00000395965 | BDP1 | chr5 | 70828254 | + | FAM172A | chr5 | 93217394 | - |
| In-frame | ENST00000358731 | ENST00000505869 | BDP1 | chr5 | 70828254 | + | FAM172A | chr5 | 93217394 | - |
| In-frame | ENST00000358731 | ENST00000509739 | BDP1 | chr5 | 70828254 | + | FAM172A | chr5 | 93217394 | - |
| In-frame | ENST00000358731 | ENST00000509163 | BDP1 | chr5 | 70828254 | + | FAM172A | chr5 | 93217394 | - |
| 5CDS-intron | ENST00000358731 | ENST00000504768 | BDP1 | chr5 | 70828254 | + | FAM172A | chr5 | 93217394 | - |
| In-frame | ENST00000380675 | ENST00000395965 | BDP1 | chr5 | 70828254 | + | FAM172A | chr5 | 93217394 | - |
| In-frame | ENST00000380675 | ENST00000505869 | BDP1 | chr5 | 70828254 | + | FAM172A | chr5 | 93217394 | - |
| In-frame | ENST00000380675 | ENST00000509739 | BDP1 | chr5 | 70828254 | + | FAM172A | chr5 | 93217394 | - |
| In-frame | ENST00000380675 | ENST00000509163 | BDP1 | chr5 | 70828254 | + | FAM172A | chr5 | 93217394 | - |
| 5CDS-intron | ENST00000380675 | ENST00000504768 | BDP1 | chr5 | 70828254 | + | FAM172A | chr5 | 93217394 | - |
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FusionProtFeatures for BDP1_FAM172A |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| BDP1 | FAM172A |