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Fusion gene ID: 41092 |
FusionGeneSummary for USP34_USP34 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: USP34_USP34 | Fusion gene ID: 41092 | Hgene | Tgene | Gene symbol | USP34 | USP34 | Gene ID | 9736 | 9736 |
| Gene name | ubiquitin specific peptidase 34 | ubiquitin specific peptidase 34 | |
| Synonyms | - | - | |
| Cytomap | 2p15 | 2p15 | |
| Type of gene | protein-coding | protein-coding | |
| Description | ubiquitin carboxyl-terminal hydrolase 34deubiquitinating enzyme 34ubiquitin specific protease 34ubiquitin thioesterase 34ubiquitin thiolesterase 34ubiquitin-specific-processing protease 34 | ubiquitin carboxyl-terminal hydrolase 34deubiquitinating enzyme 34ubiquitin specific protease 34ubiquitin thioesterase 34ubiquitin thiolesterase 34ubiquitin-specific-processing protease 34 | |
| Modification date | 20180523 | 20180523 | |
| UniProtAcc | Q70CQ2 | Q70CQ2 | |
| Ensembl transtripts involved in fusion gene | ENST00000398571, ENST00000472689, | ENST00000398571, ENST00000472689, | |
| Fusion gene scores | * DoF score | 18 X 14 X 10=2520 | 6 X 7 X 2=84 |
| # samples | 20 | 7 | |
| ** MAII score | log2(20/2520*10)=-3.65535182861255 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(7/84*10)=-0.263034405833794 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: USP34 [Title/Abstract] AND USP34 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | USP34 | GO:0016579 | protein deubiquitination | 14715245 |
| Hgene | USP34 | GO:0071108 | protein K48-linked deubiquitination | 21383061 |
| Hgene | USP34 | GO:0090263 | positive regulation of canonical Wnt signaling pathway | 21383061 |
| Tgene | USP34 | GO:0016579 | protein deubiquitination | 14715245 |
| Tgene | USP34 | GO:0071108 | protein K48-linked deubiquitination | 21383061 |
| Tgene | USP34 | GO:0090263 | positive regulation of canonical Wnt signaling pathway | 21383061 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| ChiTaRS3.1 | BF885872 | USP34 | chr2 | 61417674 | - | USP34 | chr2 | 61417753 | + | ||
| ChiTaRS3.1 | AW296692 | USP34 | chr2 | 61417775 | - | USP34 | chr2 | 61417838 | + |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| intron-3CDS | ENST00000398571 | ENST00000398571 | USP34 | chr2 | 61417674 | - | USP34 | chr2 | 61417753 | + |
| intron-intron | ENST00000398571 | ENST00000472689 | USP34 | chr2 | 61417674 | - | USP34 | chr2 | 61417753 | + |
| intron-3CDS | ENST00000472689 | ENST00000398571 | USP34 | chr2 | 61417674 | - | USP34 | chr2 | 61417753 | + |
| intron-intron | ENST00000472689 | ENST00000472689 | USP34 | chr2 | 61417674 | - | USP34 | chr2 | 61417753 | + |
| intron-intron | ENST00000398571 | ENST00000398571 | USP34 | chr2 | 61417775 | - | USP34 | chr2 | 61417838 | + |
| intron-intron | ENST00000398571 | ENST00000472689 | USP34 | chr2 | 61417775 | - | USP34 | chr2 | 61417838 | + |
| intron-intron | ENST00000472689 | ENST00000398571 | USP34 | chr2 | 61417775 | - | USP34 | chr2 | 61417838 | + |
| intron-intron | ENST00000472689 | ENST00000472689 | USP34 | chr2 | 61417775 | - | USP34 | chr2 | 61417838 | + |
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FusionProtFeatures for USP34_USP34 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| USP34 | USP34 |