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Fusion gene ID: 41062

FusionGeneSummary for USP32_RBFOX3

Fusion gene summary

Fusion gene information	Fusion gene name: USP32_RBFOX3
	Fusion gene ID: 41062
		Hgene	Tgene
	Gene symbol	USP32	RBFOX3
	Gene ID	84669	146713
	Gene name	ubiquitin specific peptidase 32	RNA binding fox-1 homolog 3
	Synonyms	NY-REN-60\|USP10	FOX-3\|FOX3\|HRNBP3\|NEUN
	Cytomap	17q23.1-q23.2	17q25.3
	Type of gene	protein-coding	protein-coding
	Description	ubiquitin carboxyl-terminal hydrolase 32deubiquitinating enzyme 32renal carcinoma antigen NY-REN-60ubiquitin specific protease 32ubiquitin thioesterase 32ubiquitin thiolesterase 32ubiquitin-specific-processing protease 32	RNA binding protein fox-1 homolog 3RNA binding protein, fox-1 homolog 3fox-1 homolog Chexaribonucleotide binding protein 3neuN antigenneuronal nuclei antigen
	Modification date	20180523	20180523
	UniProtAcc	Q8NFA0	A6NFN3
	Ensembl transtripts involved in fusion gene	ENST00000300896, ENST00000592339, ENST00000393003, ENST00000586881,	ENST00000453134, ENST00000583458, ENST00000415831, ENST00000582043, ENST00000580155, ENST00000584778, ENST00000578887,
Fusion gene scores	* DoF score	28 X 15 X 9=3780	6 X 3 X 6=108
	# samples	27	6
	** MAII score	log2(27/3780*10)=-3.8073549220576 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(6/108*10)=-0.84799690655495 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context	PubMed: USP32 [Title/Abstract] AND RBFOX3 [Title/Abstract] AND fusion [Title/Abstract]
Functional or gene categories assigned by FusionGDB annotation

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner

Gene

GO ID

GO term

PubMed ID

Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Data type	Source	Cancer type	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
TCGA	LD	ESCA	TCGA-L5-A4OQ-01A	USP32	chr17	58422842	-	RBFOX3	chr17	77303906	-

* LD: Li Ding group's fusion gene list
RV: Roel Verhaak group's fusion gene list
ChiTaRs fusion database

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
5CDS-5UTR	ENST00000300896	ENST00000453134	USP32	chr17	58422842	-	RBFOX3	chr17	77303906	-
5CDS-5UTR	ENST00000300896	ENST00000583458	USP32	chr17	58422842	-	RBFOX3	chr17	77303906	-
5CDS-5UTR	ENST00000300896	ENST00000415831	USP32	chr17	58422842	-	RBFOX3	chr17	77303906	-
5CDS-intron	ENST00000300896	ENST00000582043	USP32	chr17	58422842	-	RBFOX3	chr17	77303906	-
5CDS-5UTR	ENST00000300896	ENST00000580155	USP32	chr17	58422842	-	RBFOX3	chr17	77303906	-
5CDS-5UTR	ENST00000300896	ENST00000584778	USP32	chr17	58422842	-	RBFOX3	chr17	77303906	-
5CDS-5UTR	ENST00000300896	ENST00000578887	USP32	chr17	58422842	-	RBFOX3	chr17	77303906	-
intron-5UTR	ENST00000592339	ENST00000453134	USP32	chr17	58422842	-	RBFOX3	chr17	77303906	-
intron-5UTR	ENST00000592339	ENST00000583458	USP32	chr17	58422842	-	RBFOX3	chr17	77303906	-
intron-5UTR	ENST00000592339	ENST00000415831	USP32	chr17	58422842	-	RBFOX3	chr17	77303906	-
intron-intron	ENST00000592339	ENST00000582043	USP32	chr17	58422842	-	RBFOX3	chr17	77303906	-
intron-5UTR	ENST00000592339	ENST00000580155	USP32	chr17	58422842	-	RBFOX3	chr17	77303906	-
intron-5UTR	ENST00000592339	ENST00000584778	USP32	chr17	58422842	-	RBFOX3	chr17	77303906	-
intron-5UTR	ENST00000592339	ENST00000578887	USP32	chr17	58422842	-	RBFOX3	chr17	77303906	-
5CDS-5UTR	ENST00000393003	ENST00000453134	USP32	chr17	58422842	-	RBFOX3	chr17	77303906	-
5CDS-5UTR	ENST00000393003	ENST00000583458	USP32	chr17	58422842	-	RBFOX3	chr17	77303906	-
5CDS-5UTR	ENST00000393003	ENST00000415831	USP32	chr17	58422842	-	RBFOX3	chr17	77303906	-
5CDS-intron	ENST00000393003	ENST00000582043	USP32	chr17	58422842	-	RBFOX3	chr17	77303906	-
5CDS-5UTR	ENST00000393003	ENST00000580155	USP32	chr17	58422842	-	RBFOX3	chr17	77303906	-
5CDS-5UTR	ENST00000393003	ENST00000584778	USP32	chr17	58422842	-	RBFOX3	chr17	77303906	-
5CDS-5UTR	ENST00000393003	ENST00000578887	USP32	chr17	58422842	-	RBFOX3	chr17	77303906	-
intron-5UTR	ENST00000586881	ENST00000453134	USP32	chr17	58422842	-	RBFOX3	chr17	77303906	-
intron-5UTR	ENST00000586881	ENST00000583458	USP32	chr17	58422842	-	RBFOX3	chr17	77303906	-
intron-5UTR	ENST00000586881	ENST00000415831	USP32	chr17	58422842	-	RBFOX3	chr17	77303906	-
intron-intron	ENST00000586881	ENST00000582043	USP32	chr17	58422842	-	RBFOX3	chr17	77303906	-
intron-5UTR	ENST00000586881	ENST00000580155	USP32	chr17	58422842	-	RBFOX3	chr17	77303906	-
intron-5UTR	ENST00000586881	ENST00000584778	USP32	chr17	58422842	-	RBFOX3	chr17	77303906	-
intron-5UTR	ENST00000586881	ENST00000578887	USP32	chr17	58422842	-	RBFOX3	chr17	77303906	-

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FusionProtFeatures for USP32_RBFOX3

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
USP32 Q8NFA0	RBFOX3 A6NFN3

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Fusion gene ID: 41062

FusionGeneSummary for USP32_RBFOX3

FusionProtFeatures for USP32_RBFOX3