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Fusion gene ID: 41056 |
FusionGeneSummary for USP32_MAP3K3 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: USP32_MAP3K3 | Fusion gene ID: 41056 | Hgene | Tgene | Gene symbol | USP32 | MAP3K3 | Gene ID | 84669 | 4215 |
| Gene name | ubiquitin specific peptidase 32 | mitogen-activated protein kinase kinase kinase 3 | |
| Synonyms | NY-REN-60|USP10 | MAPKKK3|MEKK3 | |
| Cytomap | 17q23.1-q23.2 | 17q23.3 | |
| Type of gene | protein-coding | protein-coding | |
| Description | ubiquitin carboxyl-terminal hydrolase 32deubiquitinating enzyme 32renal carcinoma antigen NY-REN-60ubiquitin specific protease 32ubiquitin thioesterase 32ubiquitin thiolesterase 32ubiquitin-specific-processing protease 32 | mitogen-activated protein kinase kinase kinase 3MAP/ERK kinase kinase 3MAPK/ERK kinase kinase 3MEK kinase 3MEKK 3 | |
| Modification date | 20180523 | 20180529 | |
| UniProtAcc | Q8NFA0 | Q99759 | |
| Ensembl transtripts involved in fusion gene | ENST00000300896, ENST00000592339, ENST00000393003, ENST00000586881, | ENST00000579585, ENST00000584573, ENST00000361733, ENST00000361357, ENST00000577395, ENST00000577784, | |
| Fusion gene scores | * DoF score | 28 X 15 X 9=3780 | 8 X 6 X 3=144 |
| # samples | 27 | 9 | |
| ** MAII score | log2(27/3780*10)=-3.8073549220576 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(9/144*10)=-0.678071905112638 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: USP32 [Title/Abstract] AND MAP3K3 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Tgene | MAP3K3 | GO:0035556 | intracellular signal transduction | 15001576 |
| Tgene | MAP3K3 | GO:0046777 | protein autophosphorylation | 15001576 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | LD | BRCA | TCGA-BH-A0DZ-01A | USP32 | chr17 | 58422842 | - | MAP3K3 | chr17 | 61770909 | + |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| Frame-shift | ENST00000300896 | ENST00000579585 | USP32 | chr17 | 58422842 | - | MAP3K3 | chr17 | 61770909 | + |
| In-frame | ENST00000300896 | ENST00000584573 | USP32 | chr17 | 58422842 | - | MAP3K3 | chr17 | 61770909 | + |
| Frame-shift | ENST00000300896 | ENST00000361733 | USP32 | chr17 | 58422842 | - | MAP3K3 | chr17 | 61770909 | + |
| In-frame | ENST00000300896 | ENST00000361357 | USP32 | chr17 | 58422842 | - | MAP3K3 | chr17 | 61770909 | + |
| Frame-shift | ENST00000300896 | ENST00000577395 | USP32 | chr17 | 58422842 | - | MAP3K3 | chr17 | 61770909 | + |
| 5CDS-intron | ENST00000300896 | ENST00000577784 | USP32 | chr17 | 58422842 | - | MAP3K3 | chr17 | 61770909 | + |
| intron-3CDS | ENST00000592339 | ENST00000579585 | USP32 | chr17 | 58422842 | - | MAP3K3 | chr17 | 61770909 | + |
| intron-3CDS | ENST00000592339 | ENST00000584573 | USP32 | chr17 | 58422842 | - | MAP3K3 | chr17 | 61770909 | + |
| intron-3CDS | ENST00000592339 | ENST00000361733 | USP32 | chr17 | 58422842 | - | MAP3K3 | chr17 | 61770909 | + |
| intron-3CDS | ENST00000592339 | ENST00000361357 | USP32 | chr17 | 58422842 | - | MAP3K3 | chr17 | 61770909 | + |
| intron-3CDS | ENST00000592339 | ENST00000577395 | USP32 | chr17 | 58422842 | - | MAP3K3 | chr17 | 61770909 | + |
| intron-intron | ENST00000592339 | ENST00000577784 | USP32 | chr17 | 58422842 | - | MAP3K3 | chr17 | 61770909 | + |
| Frame-shift | ENST00000393003 | ENST00000579585 | USP32 | chr17 | 58422842 | - | MAP3K3 | chr17 | 61770909 | + |
| In-frame | ENST00000393003 | ENST00000584573 | USP32 | chr17 | 58422842 | - | MAP3K3 | chr17 | 61770909 | + |
| Frame-shift | ENST00000393003 | ENST00000361733 | USP32 | chr17 | 58422842 | - | MAP3K3 | chr17 | 61770909 | + |
| In-frame | ENST00000393003 | ENST00000361357 | USP32 | chr17 | 58422842 | - | MAP3K3 | chr17 | 61770909 | + |
| Frame-shift | ENST00000393003 | ENST00000577395 | USP32 | chr17 | 58422842 | - | MAP3K3 | chr17 | 61770909 | + |
| 5CDS-intron | ENST00000393003 | ENST00000577784 | USP32 | chr17 | 58422842 | - | MAP3K3 | chr17 | 61770909 | + |
| intron-3CDS | ENST00000586881 | ENST00000579585 | USP32 | chr17 | 58422842 | - | MAP3K3 | chr17 | 61770909 | + |
| intron-3CDS | ENST00000586881 | ENST00000584573 | USP32 | chr17 | 58422842 | - | MAP3K3 | chr17 | 61770909 | + |
| intron-3CDS | ENST00000586881 | ENST00000361733 | USP32 | chr17 | 58422842 | - | MAP3K3 | chr17 | 61770909 | + |
| intron-3CDS | ENST00000586881 | ENST00000361357 | USP32 | chr17 | 58422842 | - | MAP3K3 | chr17 | 61770909 | + |
| intron-3CDS | ENST00000586881 | ENST00000577395 | USP32 | chr17 | 58422842 | - | MAP3K3 | chr17 | 61770909 | + |
| intron-intron | ENST00000586881 | ENST00000577784 | USP32 | chr17 | 58422842 | - | MAP3K3 | chr17 | 61770909 | + |
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FusionProtFeatures for USP32_MAP3K3 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| USP32 | MAP3K3 |