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Fusion gene ID: 41053 |
FusionGeneSummary for USP32_GPR137 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: USP32_GPR137 | Fusion gene ID: 41053 | Hgene | Tgene | Gene symbol | USP32 | GPR137 | Gene ID | 84669 | 56834 |
| Gene name | ubiquitin specific peptidase 32 | G protein-coupled receptor 137 | |
| Synonyms | NY-REN-60|USP10 | C11orf4|GPR137A|TM7SF1L1 | |
| Cytomap | 17q23.1-q23.2 | 11q13.1 | |
| Type of gene | protein-coding | protein-coding | |
| Description | ubiquitin carboxyl-terminal hydrolase 32deubiquitinating enzyme 32renal carcinoma antigen NY-REN-60ubiquitin specific protease 32ubiquitin thioesterase 32ubiquitin thiolesterase 32ubiquitin-specific-processing protease 32 | integral membrane protein GPR137transmembrane 7 superfamily member 1-like 1 protein | |
| Modification date | 20180523 | 20180519 | |
| UniProtAcc | Q8NFA0 | Q96N19 | |
| Ensembl transtripts involved in fusion gene | ENST00000300896, ENST00000592339, ENST00000393003, ENST00000586881, | ENST00000411458, ENST00000539851, ENST00000377702, ENST00000438980, ENST00000313074, | |
| Fusion gene scores | * DoF score | 28 X 15 X 9=3780 | 4 X 3 X 4=48 |
| # samples | 27 | 4 | |
| ** MAII score | log2(27/3780*10)=-3.8073549220576 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(4/48*10)=-0.263034405833794 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: USP32 [Title/Abstract] AND GPR137 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | LD | BRCA | TCGA-AC-A23H-01A | USP32 | chr17 | 58469243 | - | GPR137 | chr11 | 64053982 | + |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| In-frame | ENST00000300896 | ENST00000411458 | USP32 | chr17 | 58469243 | - | GPR137 | chr11 | 64053982 | + |
| 5CDS-5UTR | ENST00000300896 | ENST00000539851 | USP32 | chr17 | 58469243 | - | GPR137 | chr11 | 64053982 | + |
| 5CDS-5UTR | ENST00000300896 | ENST00000377702 | USP32 | chr17 | 58469243 | - | GPR137 | chr11 | 64053982 | + |
| 5CDS-5UTR | ENST00000300896 | ENST00000438980 | USP32 | chr17 | 58469243 | - | GPR137 | chr11 | 64053982 | + |
| 5CDS-5UTR | ENST00000300896 | ENST00000313074 | USP32 | chr17 | 58469243 | - | GPR137 | chr11 | 64053982 | + |
| intron-3CDS | ENST00000592339 | ENST00000411458 | USP32 | chr17 | 58469243 | - | GPR137 | chr11 | 64053982 | + |
| intron-5UTR | ENST00000592339 | ENST00000539851 | USP32 | chr17 | 58469243 | - | GPR137 | chr11 | 64053982 | + |
| intron-5UTR | ENST00000592339 | ENST00000377702 | USP32 | chr17 | 58469243 | - | GPR137 | chr11 | 64053982 | + |
| intron-5UTR | ENST00000592339 | ENST00000438980 | USP32 | chr17 | 58469243 | - | GPR137 | chr11 | 64053982 | + |
| intron-5UTR | ENST00000592339 | ENST00000313074 | USP32 | chr17 | 58469243 | - | GPR137 | chr11 | 64053982 | + |
| In-frame | ENST00000393003 | ENST00000411458 | USP32 | chr17 | 58469243 | - | GPR137 | chr11 | 64053982 | + |
| 5CDS-5UTR | ENST00000393003 | ENST00000539851 | USP32 | chr17 | 58469243 | - | GPR137 | chr11 | 64053982 | + |
| 5CDS-5UTR | ENST00000393003 | ENST00000377702 | USP32 | chr17 | 58469243 | - | GPR137 | chr11 | 64053982 | + |
| 5CDS-5UTR | ENST00000393003 | ENST00000438980 | USP32 | chr17 | 58469243 | - | GPR137 | chr11 | 64053982 | + |
| 5CDS-5UTR | ENST00000393003 | ENST00000313074 | USP32 | chr17 | 58469243 | - | GPR137 | chr11 | 64053982 | + |
| intron-3CDS | ENST00000586881 | ENST00000411458 | USP32 | chr17 | 58469243 | - | GPR137 | chr11 | 64053982 | + |
| intron-5UTR | ENST00000586881 | ENST00000539851 | USP32 | chr17 | 58469243 | - | GPR137 | chr11 | 64053982 | + |
| intron-5UTR | ENST00000586881 | ENST00000377702 | USP32 | chr17 | 58469243 | - | GPR137 | chr11 | 64053982 | + |
| intron-5UTR | ENST00000586881 | ENST00000438980 | USP32 | chr17 | 58469243 | - | GPR137 | chr11 | 64053982 | + |
| intron-5UTR | ENST00000586881 | ENST00000313074 | USP32 | chr17 | 58469243 | - | GPR137 | chr11 | 64053982 | + |
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FusionProtFeatures for USP32_GPR137 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| USP32 | GPR137 |