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Fusion gene ID: 41038 |
FusionGeneSummary for USP31_ERI2 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: USP31_ERI2 | Fusion gene ID: 41038 | Hgene | Tgene | Gene symbol | USP31 | ERI2 | Gene ID | 84196 | 112479 |
| Gene name | ubiquitin specific peptidase 48 | ERI1 exoribonuclease family member 2 | |
| Synonyms | RAP1GA1|USP31 | EXOD1|ZGRF5 | |
| Cytomap | 1p36.12 | 16p12.3 | |
| Type of gene | protein-coding | protein-coding | |
| Description | ubiquitin carboxyl-terminal hydrolase 48deubiquitinating enzyme 48ubiquitin specific protease 31ubiquitin thioesterase 48ubiquitin thiolesterase 48ubiquitin-specific-processing protease 48 | ERI1 exoribonuclease 2enhanced RNAi three prime mRNA exonuclease homolog 2exonuclease domain containing 1exonuclease domain-containing protein 1exoribonuclease 2zinc finger, GRF-type containing 5 | |
| Modification date | 20180522 | 20180523 | |
| UniProtAcc | Q70CQ4 | A8K979 | |
| Ensembl transtripts involved in fusion gene | ENST00000219689, ENST00000567975, | ENST00000564349, ENST00000300005, ENST00000357967, ENST00000569729, ENST00000389345, ENST00000563117, ENST00000568251, | |
| Fusion gene scores | * DoF score | 9 X 4 X 6=216 | 2 X 2 X 2=8 |
| # samples | 9 | 2 | |
| ** MAII score | log2(9/216*10)=-1.26303440583379 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(2/8*10)=1.32192809488736 | |
| Context | PubMed: USP31 [Title/Abstract] AND ERI2 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | RV | PRAD | TCGA-HI-7168-01A | USP31 | chr16 | 23113640 | - | ERI2 | chr16 | 20811724 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| In-frame | ENST00000219689 | ENST00000564349 | USP31 | chr16 | 23113640 | - | ERI2 | chr16 | 20811724 | - |
| In-frame | ENST00000219689 | ENST00000300005 | USP31 | chr16 | 23113640 | - | ERI2 | chr16 | 20811724 | - |
| In-frame | ENST00000219689 | ENST00000357967 | USP31 | chr16 | 23113640 | - | ERI2 | chr16 | 20811724 | - |
| In-frame | ENST00000219689 | ENST00000569729 | USP31 | chr16 | 23113640 | - | ERI2 | chr16 | 20811724 | - |
| 5CDS-intron | ENST00000219689 | ENST00000389345 | USP31 | chr16 | 23113640 | - | ERI2 | chr16 | 20811724 | - |
| 5CDS-intron | ENST00000219689 | ENST00000563117 | USP31 | chr16 | 23113640 | - | ERI2 | chr16 | 20811724 | - |
| 5CDS-intron | ENST00000219689 | ENST00000568251 | USP31 | chr16 | 23113640 | - | ERI2 | chr16 | 20811724 | - |
| intron-3CDS | ENST00000567975 | ENST00000564349 | USP31 | chr16 | 23113640 | - | ERI2 | chr16 | 20811724 | - |
| intron-3CDS | ENST00000567975 | ENST00000300005 | USP31 | chr16 | 23113640 | - | ERI2 | chr16 | 20811724 | - |
| intron-3CDS | ENST00000567975 | ENST00000357967 | USP31 | chr16 | 23113640 | - | ERI2 | chr16 | 20811724 | - |
| intron-3CDS | ENST00000567975 | ENST00000569729 | USP31 | chr16 | 23113640 | - | ERI2 | chr16 | 20811724 | - |
| intron-intron | ENST00000567975 | ENST00000389345 | USP31 | chr16 | 23113640 | - | ERI2 | chr16 | 20811724 | - |
| intron-intron | ENST00000567975 | ENST00000563117 | USP31 | chr16 | 23113640 | - | ERI2 | chr16 | 20811724 | - |
| intron-intron | ENST00000567975 | ENST00000568251 | USP31 | chr16 | 23113640 | - | ERI2 | chr16 | 20811724 | - |
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FusionProtFeatures for USP31_ERI2 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| USP31 | ERI2 |