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Fusion gene ID: 40995 |
FusionGeneSummary for USP18_BAG6 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: USP18_BAG6 | Fusion gene ID: 40995 | Hgene | Tgene | Gene symbol | USP18 | BAG6 | Gene ID | 11274 | 7917 |
| Gene name | ubiquitin specific peptidase 18 | BCL2 associated athanogene 6 | |
| Synonyms | ISG43|PTORCH2|UBP43 | BAG-6|BAT3|D6S52E|G3 | |
| Cytomap | 22q11.21 | 6p21.33 | |
| Type of gene | protein-coding | protein-coding | |
| Description | ubl carboxyl-terminal hydrolase 1843 kDa ISG15-specific proteaseISG15-specific-processing proteasehUBP43ubiquitin specific protease 18ubl thioesterase 18ubl thiolesterase 18 | large proline-rich protein BAG6BAG family molecular chaperone regulator 6HLA-B-associated transcript 3large proline-rich protein BAT3protein G3protein Scythescythe | |
| Modification date | 20180523 | 20180523 | |
| UniProtAcc | Q9UMW8 | P46379 | |
| Ensembl transtripts involved in fusion gene | ENST00000215794, | ENST00000375976, ENST00000211379, ENST00000439687, ENST00000404765, ENST00000375964, ENST00000362049, ENST00000470875, ENST00000442479, ENST00000449450, ENST00000417144, ENST00000551350, ENST00000497694, ENST00000422756, ENST00000425649, ENST00000434446, ENST00000552467, ENST00000463220, ENST00000413922, ENST00000454478, ENST00000412012, ENST00000546462, ENST00000460147, ENST00000383446, ENST00000361076, ENST00000383448, ENST00000552605, ENST00000471376, ENST00000415373, ENST00000444402, ENST00000415345, ENST00000550393, ENST00000461852, ENST00000443182, ENST00000451932, ENST00000419847, ENST00000552116, ENST00000460429, | |
| Fusion gene scores | * DoF score | 4 X 5 X 4=80 | 5 X 5 X 3=75 |
| # samples | 4 | 5 | |
| ** MAII score | log2(4/80*10)=-1 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(5/75*10)=-0.584962500721156 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: USP18 [Title/Abstract] AND BAG6 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Tgene | BAG6 | GO:0002429 | immune response-activating cell surface receptor signaling pathway | 18852879 |
| Tgene | BAG6 | GO:0006915 | apoptotic process | 14960581 |
| Tgene | BAG6 | GO:0018393 | internal peptidyl-lysine acetylation | 17403783 |
| Tgene | BAG6 | GO:0030101 | natural killer cell activation | 18852879 |
| Tgene | BAG6 | GO:0030433 | ubiquitin-dependent ERAD pathway | 23129660|24981174 |
| Tgene | BAG6 | GO:0071712 | ER-associated misfolded protein catabolic process | 23129660|24981174 |
| Tgene | BAG6 | GO:0071816 | tail-anchored membrane protein insertion into ER membrane | 20676083 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | LD | OV | TCGA-24-1424-01A | USP18 | chr22 | 18640587 | + | BAG6 | chr6 | 31607003 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| Frame-shift | ENST00000215794 | ENST00000375976 | USP18 | chr22 | 18640587 | + | BAG6 | chr6 | 31607003 | - |
| Frame-shift | ENST00000215794 | ENST00000211379 | USP18 | chr22 | 18640587 | + | BAG6 | chr6 | 31607003 | - |
| Frame-shift | ENST00000215794 | ENST00000439687 | USP18 | chr22 | 18640587 | + | BAG6 | chr6 | 31607003 | - |
| Frame-shift | ENST00000215794 | ENST00000404765 | USP18 | chr22 | 18640587 | + | BAG6 | chr6 | 31607003 | - |
| Frame-shift | ENST00000215794 | ENST00000375964 | USP18 | chr22 | 18640587 | + | BAG6 | chr6 | 31607003 | - |
| Frame-shift | ENST00000215794 | ENST00000362049 | USP18 | chr22 | 18640587 | + | BAG6 | chr6 | 31607003 | - |
| 5CDS-intron | ENST00000215794 | ENST00000470875 | USP18 | chr22 | 18640587 | + | BAG6 | chr6 | 31607003 | - |
| 5CDS-intron | ENST00000215794 | ENST00000442479 | USP18 | chr22 | 18640587 | + | BAG6 | chr6 | 31607003 | - |
| 5CDS-intron | ENST00000215794 | ENST00000449450 | USP18 | chr22 | 18640587 | + | BAG6 | chr6 | 31607003 | - |
| 5CDS-intron | ENST00000215794 | ENST00000417144 | USP18 | chr22 | 18640587 | + | BAG6 | chr6 | 31607003 | - |
| 5CDS-intron | ENST00000215794 | ENST00000551350 | USP18 | chr22 | 18640587 | + | BAG6 | chr6 | 31607003 | - |
| 5CDS-intron | ENST00000215794 | ENST00000497694 | USP18 | chr22 | 18640587 | + | BAG6 | chr6 | 31607003 | - |
| 5CDS-intron | ENST00000215794 | ENST00000422756 | USP18 | chr22 | 18640587 | + | BAG6 | chr6 | 31607003 | - |
| 5CDS-intron | ENST00000215794 | ENST00000425649 | USP18 | chr22 | 18640587 | + | BAG6 | chr6 | 31607003 | - |
| 5CDS-intron | ENST00000215794 | ENST00000434446 | USP18 | chr22 | 18640587 | + | BAG6 | chr6 | 31607003 | - |
| 5CDS-intron | ENST00000215794 | ENST00000552467 | USP18 | chr22 | 18640587 | + | BAG6 | chr6 | 31607003 | - |
| 5CDS-intron | ENST00000215794 | ENST00000463220 | USP18 | chr22 | 18640587 | + | BAG6 | chr6 | 31607003 | - |
| 5CDS-intron | ENST00000215794 | ENST00000413922 | USP18 | chr22 | 18640587 | + | BAG6 | chr6 | 31607003 | - |
| 5CDS-intron | ENST00000215794 | ENST00000454478 | USP18 | chr22 | 18640587 | + | BAG6 | chr6 | 31607003 | - |
| 5CDS-intron | ENST00000215794 | ENST00000412012 | USP18 | chr22 | 18640587 | + | BAG6 | chr6 | 31607003 | - |
| 5CDS-intron | ENST00000215794 | ENST00000546462 | USP18 | chr22 | 18640587 | + | BAG6 | chr6 | 31607003 | - |
| 5CDS-intron | ENST00000215794 | ENST00000460147 | USP18 | chr22 | 18640587 | + | BAG6 | chr6 | 31607003 | - |
| 5CDS-intron | ENST00000215794 | ENST00000383446 | USP18 | chr22 | 18640587 | + | BAG6 | chr6 | 31607003 | - |
| 5CDS-intron | ENST00000215794 | ENST00000361076 | USP18 | chr22 | 18640587 | + | BAG6 | chr6 | 31607003 | - |
| 5CDS-intron | ENST00000215794 | ENST00000383448 | USP18 | chr22 | 18640587 | + | BAG6 | chr6 | 31607003 | - |
| 5CDS-intron | ENST00000215794 | ENST00000552605 | USP18 | chr22 | 18640587 | + | BAG6 | chr6 | 31607003 | - |
| 5CDS-intron | ENST00000215794 | ENST00000471376 | USP18 | chr22 | 18640587 | + | BAG6 | chr6 | 31607003 | - |
| 5CDS-intron | ENST00000215794 | ENST00000415373 | USP18 | chr22 | 18640587 | + | BAG6 | chr6 | 31607003 | - |
| 5CDS-intron | ENST00000215794 | ENST00000444402 | USP18 | chr22 | 18640587 | + | BAG6 | chr6 | 31607003 | - |
| 5CDS-intron | ENST00000215794 | ENST00000415345 | USP18 | chr22 | 18640587 | + | BAG6 | chr6 | 31607003 | - |
| 5CDS-intron | ENST00000215794 | ENST00000550393 | USP18 | chr22 | 18640587 | + | BAG6 | chr6 | 31607003 | - |
| 5CDS-intron | ENST00000215794 | ENST00000461852 | USP18 | chr22 | 18640587 | + | BAG6 | chr6 | 31607003 | - |
| 5CDS-intron | ENST00000215794 | ENST00000443182 | USP18 | chr22 | 18640587 | + | BAG6 | chr6 | 31607003 | - |
| 5CDS-intron | ENST00000215794 | ENST00000451932 | USP18 | chr22 | 18640587 | + | BAG6 | chr6 | 31607003 | - |
| 5CDS-intron | ENST00000215794 | ENST00000419847 | USP18 | chr22 | 18640587 | + | BAG6 | chr6 | 31607003 | - |
| 5CDS-intron | ENST00000215794 | ENST00000552116 | USP18 | chr22 | 18640587 | + | BAG6 | chr6 | 31607003 | - |
| 5CDS-intron | ENST00000215794 | ENST00000460429 | USP18 | chr22 | 18640587 | + | BAG6 | chr6 | 31607003 | - |
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FusionProtFeatures for USP18_BAG6 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| USP18 | BAG6 |