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Fusion gene ID: 40978 |
FusionGeneSummary for USP15_CDH4 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: USP15_CDH4 | Fusion gene ID: 40978 | Hgene | Tgene | Gene symbol | USP15 | CDH4 | Gene ID | 9958 | 1002 |
| Gene name | ubiquitin specific peptidase 15 | cadherin 4 | |
| Synonyms | UNPH-2|UNPH4 | CAD4|R-CAD|RCAD | |
| Cytomap | 12q14.1 | 20q13.33 | |
| Type of gene | protein-coding | protein-coding | |
| Description | ubiquitin carboxyl-terminal hydrolase 15deubiquitinating enzyme 15ubiquitin thioesterase 15ubiquitin thiolesterase 15ubiquitin-specific-processing protease 15 | cadherin-4R-cadherincadherin 4, type 1, R-cadherin (retinal)cadherin 4, type 1, preproproteinretinal cadherin | |
| Modification date | 20180523 | 20180523 | |
| UniProtAcc | Q9Y4E8 | P55283 | |
| Ensembl transtripts involved in fusion gene | ENST00000353364, ENST00000280377, ENST00000393654, ENST00000550632, ENST00000312635, | ENST00000360469, ENST00000543233, | |
| Fusion gene scores | * DoF score | 13 X 7 X 6=546 | 10 X 6 X 6=360 |
| # samples | 13 | 10 | |
| ** MAII score | log2(13/546*10)=-2.0703893278914 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(10/360*10)=-1.84799690655495 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: USP15 [Title/Abstract] AND CDH4 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | USP15 | GO:0007179 | transforming growth factor beta receptor signaling pathway | 21947082 |
| Hgene | USP15 | GO:0016579 | protein deubiquitination | 16005295|22344298|27368102 |
| Hgene | USP15 | GO:0030509 | BMP signaling pathway | 21947082 |
| Hgene | USP15 | GO:0035520 | monoubiquitinated protein deubiquitination | 21947082 |
| Hgene | USP15 | GO:0035616 | histone H2B conserved C-terminal lysine deubiquitination | 24526689 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | LD | BRCA | TCGA-AR-A0TX-01A | USP15 | chr12 | 62749256 | + | CDH4 | chr20 | 60318619 | + |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| Frame-shift | ENST00000353364 | ENST00000360469 | USP15 | chr12 | 62749256 | + | CDH4 | chr20 | 60318619 | + |
| 5CDS-5UTR | ENST00000353364 | ENST00000543233 | USP15 | chr12 | 62749256 | + | CDH4 | chr20 | 60318619 | + |
| Frame-shift | ENST00000280377 | ENST00000360469 | USP15 | chr12 | 62749256 | + | CDH4 | chr20 | 60318619 | + |
| 5CDS-5UTR | ENST00000280377 | ENST00000543233 | USP15 | chr12 | 62749256 | + | CDH4 | chr20 | 60318619 | + |
| Frame-shift | ENST00000393654 | ENST00000360469 | USP15 | chr12 | 62749256 | + | CDH4 | chr20 | 60318619 | + |
| 5CDS-5UTR | ENST00000393654 | ENST00000543233 | USP15 | chr12 | 62749256 | + | CDH4 | chr20 | 60318619 | + |
| intron-3CDS | ENST00000550632 | ENST00000360469 | USP15 | chr12 | 62749256 | + | CDH4 | chr20 | 60318619 | + |
| intron-5UTR | ENST00000550632 | ENST00000543233 | USP15 | chr12 | 62749256 | + | CDH4 | chr20 | 60318619 | + |
| intron-3CDS | ENST00000312635 | ENST00000360469 | USP15 | chr12 | 62749256 | + | CDH4 | chr20 | 60318619 | + |
| intron-5UTR | ENST00000312635 | ENST00000543233 | USP15 | chr12 | 62749256 | + | CDH4 | chr20 | 60318619 | + |
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FusionProtFeatures for USP15_CDH4 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| USP15 | CDH4 |