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Fusion gene ID: 40967 |
FusionGeneSummary for USP12_LNX2 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: USP12_LNX2 | Fusion gene ID: 40967 | Hgene | Tgene | Gene symbol | USP12 | LNX2 | Gene ID | 219333 | 222484 |
| Gene name | ubiquitin specific peptidase 12 | ligand of numb-protein X 2 | |
| Synonyms | UBH1|USP12L1 | PDZRN1 | |
| Cytomap | 13q12.13 | 13q12.2 | |
| Type of gene | protein-coding | protein-coding | |
| Description | ubiquitin carboxyl-terminal hydrolase 12deubiquitinating enzyme 12ubiquitin specific protease 12 like 1ubiquitin thioesterase 12ubiquitin thiolesterase 12ubiquitin-hydrolyzing enzyme 1ubiquitin-specific-processing protease 12 | ligand of Numb protein X 2PDZ domain containing ring finger 1PDZ domain-containing RING finger protein 1numb-binding protein 2 | |
| Modification date | 20180519 | 20180519 | |
| UniProtAcc | O75317 | Q8N448 | |
| Ensembl transtripts involved in fusion gene | ENST00000282344, | ENST00000316334, | |
| Fusion gene scores | * DoF score | 5 X 3 X 5=75 | 1 X 1 X 1=1 |
| # samples | 5 | 1 | |
| ** MAII score | log2(5/75*10)=-0.584962500721156 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(1/1*10)=3.32192809488736 | |
| Context | PubMed: USP12 [Title/Abstract] AND LNX2 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | Tumor suppressor gene involved fusion gene, in-frame but not retained their domain. | ||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | USP12 | GO:0016579 | protein deubiquitination | 19075014|24145035 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | RV | STAD | TCGA-BR-4357-01A | USP12 | chr13 | 27669738 | - | LNX2 | chr13 | 28134122 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| In-frame | ENST00000282344 | ENST00000316334 | USP12 | chr13 | 27669738 | - | LNX2 | chr13 | 28134122 | - |
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FusionProtFeatures for USP12_LNX2 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| USP12 | LNX2 |