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Fusion gene ID: 40911 |
FusionGeneSummary for URI1_IFNL1 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: URI1_IFNL1 | Fusion gene ID: 40911 | Hgene | Tgene | Gene symbol | URI1 | IFNL1 | Gene ID | 8725 | 282618 |
| Gene name | URI1, prefoldin like chaperone | interferon lambda 1 | |
| Synonyms | C19orf2|NNX3|PPP1R19|RMP|URI | IL-29|IL29 | |
| Cytomap | 19q12 | 19q13.2 | |
| Type of gene | protein-coding | protein-coding | |
| Description | unconventional prefoldin RPB5 interactor 1RNA polymerase II subunit 5-mediating proteinRPB5-mediating proteinprotein phosphatase 1, regulatory subunit 19 | interferon lambda-1IFN-lambda-1cytokine Zcyto21interleukin 29 (interferon, lambda 1)interleukin-29 | |
| Modification date | 20180523 | 20180523 | |
| UniProtAcc | O94763 | Q8IU54 | |
| Ensembl transtripts involved in fusion gene | ENST00000360605, ENST00000542441, ENST00000392271, ENST00000312051, ENST00000574176, | ENST00000333625, | |
| Fusion gene scores | * DoF score | 22 X 6 X 12=1584 | 4 X 1 X 3=12 |
| # samples | 23 | 4 | |
| ** MAII score | log2(23/1584*10)=-2.78386656913523 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(4/12*10)=1.73696559416621 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | |
| Context | PubMed: URI1 [Title/Abstract] AND IFNL1 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | URI1 | GO:0000122 | negative regulation of transcription by RNA polymerase II | 12737519|15367675|21730289 |
| Hgene | URI1 | GO:0001558 | regulation of cell growth | 21730289 |
| Hgene | URI1 | GO:0071363 | cellular response to growth factor stimulus | 17936702 |
| Hgene | URI1 | GO:0071383 | cellular response to steroid hormone stimulus | 21730289 |
| Tgene | IFNL1 | GO:0002829 | negative regulation of type 2 immune response | 19346497 |
| Tgene | IFNL1 | GO:0008285 | negative regulation of cell proliferation | 15166220|15899585 |
| Tgene | IFNL1 | GO:0032696 | negative regulation of interleukin-13 production | 19346497 |
| Tgene | IFNL1 | GO:0032714 | negative regulation of interleukin-5 production | 19346497 |
| Tgene | IFNL1 | GO:0032729 | positive regulation of interferon-gamma production | 19346497 |
| Tgene | IFNL1 | GO:0042531 | positive regulation of tyrosine phosphorylation of STAT protein | 15166220 |
| Tgene | IFNL1 | GO:0043381 | negative regulation of memory T cell differentiation | 19346497 |
| Tgene | IFNL1 | GO:0045345 | positive regulation of MHC class I biosynthetic process | 12483210 |
| Tgene | IFNL1 | GO:0045581 | negative regulation of T cell differentiation | 19346497 |
| Tgene | IFNL1 | GO:0045892 | negative regulation of transcription, DNA-templated | 19346497 |
| Tgene | IFNL1 | GO:0045893 | positive regulation of transcription, DNA-templated | 12483210 |
| Tgene | IFNL1 | GO:0046427 | positive regulation of JAK-STAT cascade | 12483210 |
| Tgene | IFNL1 | GO:0051607 | defense response to virus | 12469119 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | LD | BRCA | TCGA-A2-A3XX-01A | URI1 | chr19 | 30462134 | + | IFNL1 | chr19 | 39787445 | + |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| Frame-shift | ENST00000360605 | ENST00000333625 | URI1 | chr19 | 30462134 | + | IFNL1 | chr19 | 39787445 | + |
| Frame-shift | ENST00000542441 | ENST00000333625 | URI1 | chr19 | 30462134 | + | IFNL1 | chr19 | 39787445 | + |
| 5UTR-3CDS | ENST00000392271 | ENST00000333625 | URI1 | chr19 | 30462134 | + | IFNL1 | chr19 | 39787445 | + |
| intron-3CDS | ENST00000312051 | ENST00000333625 | URI1 | chr19 | 30462134 | + | IFNL1 | chr19 | 39787445 | + |
| intron-3CDS | ENST00000574176 | ENST00000333625 | URI1 | chr19 | 30462134 | + | IFNL1 | chr19 | 39787445 | + |
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FusionProtFeatures for URI1_IFNL1 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| URI1 | IFNL1 |