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Fusion gene ID: 40894 |
FusionGeneSummary for UQCRH_TSPAN1 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: UQCRH_TSPAN1 | Fusion gene ID: 40894 | Hgene | Tgene | Gene symbol | UQCRH | TSPAN1 | Gene ID | 7388 | 10103 |
| Gene name | ubiquinol-cytochrome c reductase hinge protein | tetraspanin 1 | |
| Synonyms | QCR6|UQCR8 | NET1|TM4C|TM4SF | |
| Cytomap | 1p33 | 1p34.1 | |
| Type of gene | protein-coding | protein-coding | |
| Description | cytochrome b-c1 complex subunit 6, mitochondrialcomplex III subunit 6cytochrome c1 non-heme 11 kDa proteinmitochondrial hinge proteinubiquinol-cytochrome c reductase complex 11 kDa proteinubiquinol-cytochrome c reductase, complex III subunit VIII | tetraspanin-1tetraspan 1 | |
| Modification date | 20180523 | 20180523 | |
| UniProtAcc | P07919 | O60635 | |
| Ensembl transtripts involved in fusion gene | ENST00000311672, ENST00000486951, | ENST00000498443, ENST00000372003, | |
| Fusion gene scores | * DoF score | 5 X 5 X 3=75 | 1 X 1 X 1=1 |
| # samples | 5 | 1 | |
| ** MAII score | log2(5/75*10)=-0.584962500721156 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(1/1*10)=3.32192809488736 | |
| Context | PubMed: UQCRH [Title/Abstract] AND TSPAN1 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Tgene | TSPAN1 | GO:0008283 | cell proliferation | 22378020 |
| Tgene | TSPAN1 | GO:0050821 | protein stabilization | 21836059 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | LD | SKCM | TCGA-EE-A2MS-06A | UQCRH | chr1 | 46774799 | + | TSPAN1 | chr1 | 46649863 | + |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| 5CDS-3UTR | ENST00000311672 | ENST00000498443 | UQCRH | chr1 | 46774799 | + | TSPAN1 | chr1 | 46649863 | + |
| 5CDS-3UTR | ENST00000311672 | ENST00000372003 | UQCRH | chr1 | 46774799 | + | TSPAN1 | chr1 | 46649863 | + |
| 3UTR-3UTR | ENST00000486951 | ENST00000498443 | UQCRH | chr1 | 46774799 | + | TSPAN1 | chr1 | 46649863 | + |
| 3UTR-3UTR | ENST00000486951 | ENST00000372003 | UQCRH | chr1 | 46774799 | + | TSPAN1 | chr1 | 46649863 | + |
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FusionProtFeatures for UQCRH_TSPAN1 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| UQCRH | TSPAN1 |