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Fusion gene ID: 40823 |
FusionGeneSummary for UNC79_BRF1 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: UNC79_BRF1 | Fusion gene ID: 40823 | Hgene | Tgene | Gene symbol | UNC79 | BRF1 | Gene ID | 57578 | 2972 |
| Gene name | unc-79 homolog, NALCN channel complex subunit | BRF1, RNA polymerase III transcription initiation factor subunit | |
| Synonyms | KIAA1409 | BRF|BRF-1|CFDS|GTF3B|HEL-S-76p|TAF3B2|TAF3C|TAFIII90|TF3B90|TFIIIB90|hBRF | |
| Cytomap | 14q32.12 | 14q32.33 | |
| Type of gene | protein-coding | protein-coding | |
| Description | protein unc-79 homologunc-79 homolog | transcription factor IIIB 90 kDa subunitB - related factor 1BRF1 homolog, subunit of RNA polymerase III transcription initiation factor IIIBBRF1, RNA polymerase III transcription initiation factor 90 kDa subunitTATA box binding protein (TBP)-associate | |
| Modification date | 20180519 | 20180519 | |
| UniProtAcc | Q9P2D8 | Q92994 | |
| Ensembl transtripts involved in fusion gene | ENST00000256339, ENST00000555664, ENST00000553484, ENST00000393151, | ENST00000546474, ENST00000327359, ENST00000440513, ENST00000392557, ENST00000379937, ENST00000547530, ENST00000446501, ENST00000379932, ENST00000551787, ENST00000549044, ENST00000548421, | |
| Fusion gene scores | * DoF score | 2 X 2 X 2=8 | 6 X 6 X 5=180 |
| # samples | 3 | 6 | |
| ** MAII score | log2(3/8*10)=1.90689059560852 | log2(6/180*10)=-1.58496250072116 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: UNC79 [Title/Abstract] AND BRF1 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | Tumor suppressor gene involved fusion gene, in-frame but not retained their domain. Tumor suppressor gene involved fusion gene, retained protein feature but frameshift. DDR (DNA damage repair) gene involved fusion gene, in-frame but not retained their domain. | ||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | LD | LGG | TCGA-DU-A5TU-01A | UNC79 | chr14 | 94069764 | + | BRF1 | chr14 | 105752713 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| In-frame | ENST00000256339 | ENST00000546474 | UNC79 | chr14 | 94069764 | + | BRF1 | chr14 | 105752713 | - |
| 5CDS-5UTR | ENST00000256339 | ENST00000327359 | UNC79 | chr14 | 94069764 | + | BRF1 | chr14 | 105752713 | - |
| 5CDS-5UTR | ENST00000256339 | ENST00000440513 | UNC79 | chr14 | 94069764 | + | BRF1 | chr14 | 105752713 | - |
| 5CDS-intron | ENST00000256339 | ENST00000392557 | UNC79 | chr14 | 94069764 | + | BRF1 | chr14 | 105752713 | - |
| 5CDS-intron | ENST00000256339 | ENST00000379937 | UNC79 | chr14 | 94069764 | + | BRF1 | chr14 | 105752713 | - |
| 5CDS-intron | ENST00000256339 | ENST00000547530 | UNC79 | chr14 | 94069764 | + | BRF1 | chr14 | 105752713 | - |
| 5CDS-intron | ENST00000256339 | ENST00000446501 | UNC79 | chr14 | 94069764 | + | BRF1 | chr14 | 105752713 | - |
| 5CDS-intron | ENST00000256339 | ENST00000379932 | UNC79 | chr14 | 94069764 | + | BRF1 | chr14 | 105752713 | - |
| 5CDS-intron | ENST00000256339 | ENST00000551787 | UNC79 | chr14 | 94069764 | + | BRF1 | chr14 | 105752713 | - |
| 5CDS-intron | ENST00000256339 | ENST00000549044 | UNC79 | chr14 | 94069764 | + | BRF1 | chr14 | 105752713 | - |
| 5CDS-intron | ENST00000256339 | ENST00000548421 | UNC79 | chr14 | 94069764 | + | BRF1 | chr14 | 105752713 | - |
| In-frame | ENST00000555664 | ENST00000546474 | UNC79 | chr14 | 94069764 | + | BRF1 | chr14 | 105752713 | - |
| 5CDS-5UTR | ENST00000555664 | ENST00000327359 | UNC79 | chr14 | 94069764 | + | BRF1 | chr14 | 105752713 | - |
| 5CDS-5UTR | ENST00000555664 | ENST00000440513 | UNC79 | chr14 | 94069764 | + | BRF1 | chr14 | 105752713 | - |
| 5CDS-intron | ENST00000555664 | ENST00000392557 | UNC79 | chr14 | 94069764 | + | BRF1 | chr14 | 105752713 | - |
| 5CDS-intron | ENST00000555664 | ENST00000379937 | UNC79 | chr14 | 94069764 | + | BRF1 | chr14 | 105752713 | - |
| 5CDS-intron | ENST00000555664 | ENST00000547530 | UNC79 | chr14 | 94069764 | + | BRF1 | chr14 | 105752713 | - |
| 5CDS-intron | ENST00000555664 | ENST00000446501 | UNC79 | chr14 | 94069764 | + | BRF1 | chr14 | 105752713 | - |
| 5CDS-intron | ENST00000555664 | ENST00000379932 | UNC79 | chr14 | 94069764 | + | BRF1 | chr14 | 105752713 | - |
| 5CDS-intron | ENST00000555664 | ENST00000551787 | UNC79 | chr14 | 94069764 | + | BRF1 | chr14 | 105752713 | - |
| 5CDS-intron | ENST00000555664 | ENST00000549044 | UNC79 | chr14 | 94069764 | + | BRF1 | chr14 | 105752713 | - |
| 5CDS-intron | ENST00000555664 | ENST00000548421 | UNC79 | chr14 | 94069764 | + | BRF1 | chr14 | 105752713 | - |
| In-frame | ENST00000553484 | ENST00000546474 | UNC79 | chr14 | 94069764 | + | BRF1 | chr14 | 105752713 | - |
| 5CDS-5UTR | ENST00000553484 | ENST00000327359 | UNC79 | chr14 | 94069764 | + | BRF1 | chr14 | 105752713 | - |
| 5CDS-5UTR | ENST00000553484 | ENST00000440513 | UNC79 | chr14 | 94069764 | + | BRF1 | chr14 | 105752713 | - |
| 5CDS-intron | ENST00000553484 | ENST00000392557 | UNC79 | chr14 | 94069764 | + | BRF1 | chr14 | 105752713 | - |
| 5CDS-intron | ENST00000553484 | ENST00000379937 | UNC79 | chr14 | 94069764 | + | BRF1 | chr14 | 105752713 | - |
| 5CDS-intron | ENST00000553484 | ENST00000547530 | UNC79 | chr14 | 94069764 | + | BRF1 | chr14 | 105752713 | - |
| 5CDS-intron | ENST00000553484 | ENST00000446501 | UNC79 | chr14 | 94069764 | + | BRF1 | chr14 | 105752713 | - |
| 5CDS-intron | ENST00000553484 | ENST00000379932 | UNC79 | chr14 | 94069764 | + | BRF1 | chr14 | 105752713 | - |
| 5CDS-intron | ENST00000553484 | ENST00000551787 | UNC79 | chr14 | 94069764 | + | BRF1 | chr14 | 105752713 | - |
| 5CDS-intron | ENST00000553484 | ENST00000549044 | UNC79 | chr14 | 94069764 | + | BRF1 | chr14 | 105752713 | - |
| 5CDS-intron | ENST00000553484 | ENST00000548421 | UNC79 | chr14 | 94069764 | + | BRF1 | chr14 | 105752713 | - |
| In-frame | ENST00000393151 | ENST00000546474 | UNC79 | chr14 | 94069764 | + | BRF1 | chr14 | 105752713 | - |
| 5CDS-5UTR | ENST00000393151 | ENST00000327359 | UNC79 | chr14 | 94069764 | + | BRF1 | chr14 | 105752713 | - |
| 5CDS-5UTR | ENST00000393151 | ENST00000440513 | UNC79 | chr14 | 94069764 | + | BRF1 | chr14 | 105752713 | - |
| 5CDS-intron | ENST00000393151 | ENST00000392557 | UNC79 | chr14 | 94069764 | + | BRF1 | chr14 | 105752713 | - |
| 5CDS-intron | ENST00000393151 | ENST00000379937 | UNC79 | chr14 | 94069764 | + | BRF1 | chr14 | 105752713 | - |
| 5CDS-intron | ENST00000393151 | ENST00000547530 | UNC79 | chr14 | 94069764 | + | BRF1 | chr14 | 105752713 | - |
| 5CDS-intron | ENST00000393151 | ENST00000446501 | UNC79 | chr14 | 94069764 | + | BRF1 | chr14 | 105752713 | - |
| 5CDS-intron | ENST00000393151 | ENST00000379932 | UNC79 | chr14 | 94069764 | + | BRF1 | chr14 | 105752713 | - |
| 5CDS-intron | ENST00000393151 | ENST00000551787 | UNC79 | chr14 | 94069764 | + | BRF1 | chr14 | 105752713 | - |
| 5CDS-intron | ENST00000393151 | ENST00000549044 | UNC79 | chr14 | 94069764 | + | BRF1 | chr14 | 105752713 | - |
| 5CDS-intron | ENST00000393151 | ENST00000548421 | UNC79 | chr14 | 94069764 | + | BRF1 | chr14 | 105752713 | - |
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FusionProtFeatures for UNC79_BRF1 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| UNC79 | BRF1 |