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Fusion gene ID: 40797

FusionGeneSummary for UNC13D_FBF1

Fusion gene summary

Fusion gene information	Fusion gene name: UNC13D_FBF1
	Fusion gene ID: 40797
		Hgene	Tgene
	Gene symbol	UNC13D	FBF1
	Gene ID	201294	85302
	Gene name	unc-13 homolog D	Fas binding factor 1
	Synonyms	FHL3\|HLH3\|HPLH3\|Munc13-4	Alb\|FBF-1
	Cytomap	17q25.1	17q25.1
	Type of gene	protein-coding	protein-coding
	Description	protein unc-13 homolog D	fas-binding factor 1Fas (TNFRSF6) binding factor 1Fas binding protein 1albatrossprotein albatross
	Modification date	20180522	20180519
	UniProtAcc	Q70J99	Q8TES7
	Ensembl transtripts involved in fusion gene	ENST00000207549, ENST00000412096, ENST00000587504,	ENST00000586717, ENST00000319129, ENST00000389570, ENST00000586631, ENST00000588478,
Fusion gene scores	* DoF score	5 X 6 X 6=180	1 X 2 X 2=4
	# samples	6	2
	** MAII score	log2(6/180*10)=-1.58496250072116 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(2/4*10)=2.32192809488736
Context	PubMed: UNC13D [Title/Abstract] AND FBF1 [Title/Abstract] AND fusion [Title/Abstract]
Functional or gene categories assigned by FusionGDB annotation

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner

Gene

GO ID

GO term

PubMed ID

Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Data type	Source	Cancer type	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
TCGA	RV	LUSC	TCGA-94-8491-01A	UNC13D	chr17	73838514	-	FBF1	chr17	73919719	-
TCGA	RV	UCS	TCGA-N5-A4RJ-01A	UNC13D	chr17	73826109	-	FBF1	chr17	73914350	-

* LD: Li Ding group's fusion gene list
RV: Roel Verhaak group's fusion gene list
ChiTaRs fusion database

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
In-frame	ENST00000207549	ENST00000586717	UNC13D	chr17	73838514	-	FBF1	chr17	73919719	-
In-frame	ENST00000207549	ENST00000319129	UNC13D	chr17	73838514	-	FBF1	chr17	73919719	-
In-frame	ENST00000207549	ENST00000389570	UNC13D	chr17	73838514	-	FBF1	chr17	73919719	-
5CDS-intron	ENST00000207549	ENST00000586631	UNC13D	chr17	73838514	-	FBF1	chr17	73919719	-
5CDS-intron	ENST00000207549	ENST00000588478	UNC13D	chr17	73838514	-	FBF1	chr17	73919719	-
In-frame	ENST00000412096	ENST00000586717	UNC13D	chr17	73838514	-	FBF1	chr17	73919719	-
In-frame	ENST00000412096	ENST00000319129	UNC13D	chr17	73838514	-	FBF1	chr17	73919719	-
In-frame	ENST00000412096	ENST00000389570	UNC13D	chr17	73838514	-	FBF1	chr17	73919719	-
5CDS-intron	ENST00000412096	ENST00000586631	UNC13D	chr17	73838514	-	FBF1	chr17	73919719	-
5CDS-intron	ENST00000412096	ENST00000588478	UNC13D	chr17	73838514	-	FBF1	chr17	73919719	-
5UTR-3CDS	ENST00000587504	ENST00000586717	UNC13D	chr17	73838514	-	FBF1	chr17	73919719	-
5UTR-3CDS	ENST00000587504	ENST00000319129	UNC13D	chr17	73838514	-	FBF1	chr17	73919719	-
5UTR-3CDS	ENST00000587504	ENST00000389570	UNC13D	chr17	73838514	-	FBF1	chr17	73919719	-
5UTR-intron	ENST00000587504	ENST00000586631	UNC13D	chr17	73838514	-	FBF1	chr17	73919719	-
5UTR-intron	ENST00000587504	ENST00000588478	UNC13D	chr17	73838514	-	FBF1	chr17	73919719	-
In-frame	ENST00000207549	ENST00000586717	UNC13D	chr17	73826109	-	FBF1	chr17	73914350	-
In-frame	ENST00000207549	ENST00000319129	UNC13D	chr17	73826109	-	FBF1	chr17	73914350	-
In-frame	ENST00000207549	ENST00000389570	UNC13D	chr17	73826109	-	FBF1	chr17	73914350	-
5CDS-intron	ENST00000207549	ENST00000586631	UNC13D	chr17	73826109	-	FBF1	chr17	73914350	-
5CDS-intron	ENST00000207549	ENST00000588478	UNC13D	chr17	73826109	-	FBF1	chr17	73914350	-
In-frame	ENST00000412096	ENST00000586717	UNC13D	chr17	73826109	-	FBF1	chr17	73914350	-
In-frame	ENST00000412096	ENST00000319129	UNC13D	chr17	73826109	-	FBF1	chr17	73914350	-
In-frame	ENST00000412096	ENST00000389570	UNC13D	chr17	73826109	-	FBF1	chr17	73914350	-
5CDS-intron	ENST00000412096	ENST00000586631	UNC13D	chr17	73826109	-	FBF1	chr17	73914350	-
5CDS-intron	ENST00000412096	ENST00000588478	UNC13D	chr17	73826109	-	FBF1	chr17	73914350	-
intron-3CDS	ENST00000587504	ENST00000586717	UNC13D	chr17	73826109	-	FBF1	chr17	73914350	-
intron-3CDS	ENST00000587504	ENST00000319129	UNC13D	chr17	73826109	-	FBF1	chr17	73914350	-
intron-3CDS	ENST00000587504	ENST00000389570	UNC13D	chr17	73826109	-	FBF1	chr17	73914350	-
intron-intron	ENST00000587504	ENST00000586631	UNC13D	chr17	73826109	-	FBF1	chr17	73914350	-
intron-intron	ENST00000587504	ENST00000588478	UNC13D	chr17	73826109	-	FBF1	chr17	73914350	-

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FusionProtFeatures for UNC13D_FBF1

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
UNC13D Q70J99	FBF1 Q8TES7

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Fusion gene ID: 40797

FusionGeneSummary for UNC13D_FBF1

FusionProtFeatures for UNC13D_FBF1