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Fusion gene ID: 40753 |
FusionGeneSummary for UIMC1_LILRB1 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: UIMC1_LILRB1 | Fusion gene ID: 40753 | Hgene | Tgene | Gene symbol | UIMC1 | LILRB1 | Gene ID | 51720 | 10859 |
| Gene name | ubiquitin interaction motif containing 1 | leukocyte immunoglobulin like receptor B1 | |
| Synonyms | RAP80|X2HRIP110 | CD85J|ILT-2|ILT2|LIR-1|LIR1|MIR-7|MIR7|PIR-B|PIRB | |
| Cytomap | 5q35.2 | 19q13.42 | |
| Type of gene | protein-coding | protein-coding | |
| Description | BRCA1-A complex subunit RAP80receptor-associated protein 80retinoid X receptor-interacting protein 110 | leukocyte immunoglobulin-like receptor subfamily B member 1CD85 antigen-like family member JIg-like transcript 2leucocyte Ig-like receptor B1leukocyte immunoglobulin-like receptor subfamily B member 1 soluble isoformleukocyte immunoglobulin-like rece | |
| Modification date | 20180523 | 20180527 | |
| UniProtAcc | Q96RL1 | Q8NHL6 | |
| Ensembl transtripts involved in fusion gene | ENST00000377227, ENST00000377219, ENST00000506128, ENST00000511320, ENST00000503273, | ENST00000418536, ENST00000448689, ENST00000396321, ENST00000396331, ENST00000396327, ENST00000434867, ENST00000324602, ENST00000396332, ENST00000427581, ENST00000396317, ENST00000396315, ENST00000462628, | |
| Fusion gene scores | * DoF score | 7 X 5 X 6=210 | 1 X 1 X 1=1 |
| # samples | 8 | 1 | |
| ** MAII score | log2(8/210*10)=-1.39231742277876 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(1/1*10)=3.32192809488736 | |
| Context | PubMed: UIMC1 [Title/Abstract] AND LILRB1 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | UIMC1 | GO:0045892 | negative regulation of transcription, DNA-templated | 12080054 |
| Tgene | LILRB1 | GO:0001915 | negative regulation of T cell mediated cytotoxicity | 21213105 |
| Tgene | LILRB1 | GO:0002230 | positive regulation of defense response to virus by host | 18398485 |
| Tgene | LILRB1 | GO:0002309 | T cell proliferation involved in immune response | 18094328 |
| Tgene | LILRB1 | GO:0002740 | negative regulation of cytokine secretion involved in immune response | 18094328 |
| Tgene | LILRB1 | GO:0002774 | Fc receptor mediated inhibitory signaling pathway | 9842885 |
| Tgene | LILRB1 | GO:0007165 | signal transduction | 18802077 |
| Tgene | LILRB1 | GO:0009615 | response to virus | 9285411|17869268|18094328 |
| Tgene | LILRB1 | GO:0010628 | positive regulation of gene expression | 18094328 |
| Tgene | LILRB1 | GO:0014063 | negative regulation of serotonin secretion | 11907092 |
| Tgene | LILRB1 | GO:0032609 | interferon-gamma production | 11907092 |
| Tgene | LILRB1 | GO:0032689 | negative regulation of interferon-gamma production | 17869268 |
| Tgene | LILRB1 | GO:0032945 | negative regulation of mononuclear cell proliferation | 21551166 |
| Tgene | LILRB1 | GO:0035548 | negative regulation of interferon-beta secretion | 21213105 |
| Tgene | LILRB1 | GO:0042130 | negative regulation of T cell proliferation | 15585844 |
| Tgene | LILRB1 | GO:0042536 | negative regulation of tumor necrosis factor biosynthetic process | 18684926 |
| Tgene | LILRB1 | GO:0043065 | positive regulation of apoptotic process | 21551166 |
| Tgene | LILRB1 | GO:0045077 | negative regulation of interferon-gamma biosynthetic process | 18684926 |
| Tgene | LILRB1 | GO:0045786 | negative regulation of cell cycle | 21551166 |
| Tgene | LILRB1 | GO:0045806 | negative regulation of endocytosis | 18094328 |
| Tgene | LILRB1 | GO:0045919 | positive regulation of cytolysis | 18684926 |
| Tgene | LILRB1 | GO:0045953 | negative regulation of natural killer cell mediated cytotoxicity | 18398485 |
| Tgene | LILRB1 | GO:0046636 | negative regulation of alpha-beta T cell activation | 21213105 |
| Tgene | LILRB1 | GO:0051607 | defense response to virus | 15585844 |
| Tgene | LILRB1 | GO:0051926 | negative regulation of calcium ion transport | 9842885 |
| Tgene | LILRB1 | GO:0072643 | interferon-gamma secretion | 15585844 |
| Tgene | LILRB1 | GO:2000669 | negative regulation of dendritic cell apoptotic process | 18094328 |
| Tgene | LILRB1 | GO:2001180 | negative regulation of interleukin-10 secretion | 18094328 |
| Tgene | LILRB1 | GO:2001183 | negative regulation of interleukin-12 secretion | 18094328 |
| Tgene | LILRB1 | GO:2001186 | negative regulation of CD8-positive, alpha-beta T cell activation | 21213105 |
| Tgene | LILRB1 | GO:2001189 | negative regulation of T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell | 18094328 |
| Tgene | LILRB1 | GO:2001193 | positive regulation of gamma-delta T cell activation involved in immune response | 21233315 |
| Tgene | LILRB1 | GO:2001202 | negative regulation of transforming growth factor-beta secretion | 18094328 |
| Tgene | LILRB1 | GO:2001205 | negative regulation of osteoclast development | 18802077 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | LD | OV | TCGA-13-0893-01B | UIMC1 | chr5 | 176409470 | - | LILRB1 | chr19 | 55142477 | + |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| 5CDS-intron | ENST00000377227 | ENST00000418536 | UIMC1 | chr5 | 176409470 | - | LILRB1 | chr19 | 55142477 | + |
| 5CDS-intron | ENST00000377227 | ENST00000448689 | UIMC1 | chr5 | 176409470 | - | LILRB1 | chr19 | 55142477 | + |
| 5CDS-intron | ENST00000377227 | ENST00000396321 | UIMC1 | chr5 | 176409470 | - | LILRB1 | chr19 | 55142477 | + |
| 5CDS-5UTR | ENST00000377227 | ENST00000396331 | UIMC1 | chr5 | 176409470 | - | LILRB1 | chr19 | 55142477 | + |
| 5CDS-5UTR | ENST00000377227 | ENST00000396327 | UIMC1 | chr5 | 176409470 | - | LILRB1 | chr19 | 55142477 | + |
| 5CDS-5UTR | ENST00000377227 | ENST00000434867 | UIMC1 | chr5 | 176409470 | - | LILRB1 | chr19 | 55142477 | + |
| 5CDS-5UTR | ENST00000377227 | ENST00000324602 | UIMC1 | chr5 | 176409470 | - | LILRB1 | chr19 | 55142477 | + |
| 5CDS-5UTR | ENST00000377227 | ENST00000396332 | UIMC1 | chr5 | 176409470 | - | LILRB1 | chr19 | 55142477 | + |
| 5CDS-5UTR | ENST00000377227 | ENST00000427581 | UIMC1 | chr5 | 176409470 | - | LILRB1 | chr19 | 55142477 | + |
| 5CDS-intron | ENST00000377227 | ENST00000396317 | UIMC1 | chr5 | 176409470 | - | LILRB1 | chr19 | 55142477 | + |
| 5CDS-intron | ENST00000377227 | ENST00000396315 | UIMC1 | chr5 | 176409470 | - | LILRB1 | chr19 | 55142477 | + |
| 5CDS-intron | ENST00000377227 | ENST00000462628 | UIMC1 | chr5 | 176409470 | - | LILRB1 | chr19 | 55142477 | + |
| 5CDS-intron | ENST00000377219 | ENST00000418536 | UIMC1 | chr5 | 176409470 | - | LILRB1 | chr19 | 55142477 | + |
| 5CDS-intron | ENST00000377219 | ENST00000448689 | UIMC1 | chr5 | 176409470 | - | LILRB1 | chr19 | 55142477 | + |
| 5CDS-intron | ENST00000377219 | ENST00000396321 | UIMC1 | chr5 | 176409470 | - | LILRB1 | chr19 | 55142477 | + |
| 5CDS-5UTR | ENST00000377219 | ENST00000396331 | UIMC1 | chr5 | 176409470 | - | LILRB1 | chr19 | 55142477 | + |
| 5CDS-5UTR | ENST00000377219 | ENST00000396327 | UIMC1 | chr5 | 176409470 | - | LILRB1 | chr19 | 55142477 | + |
| 5CDS-5UTR | ENST00000377219 | ENST00000434867 | UIMC1 | chr5 | 176409470 | - | LILRB1 | chr19 | 55142477 | + |
| 5CDS-5UTR | ENST00000377219 | ENST00000324602 | UIMC1 | chr5 | 176409470 | - | LILRB1 | chr19 | 55142477 | + |
| 5CDS-5UTR | ENST00000377219 | ENST00000396332 | UIMC1 | chr5 | 176409470 | - | LILRB1 | chr19 | 55142477 | + |
| 5CDS-5UTR | ENST00000377219 | ENST00000427581 | UIMC1 | chr5 | 176409470 | - | LILRB1 | chr19 | 55142477 | + |
| 5CDS-intron | ENST00000377219 | ENST00000396317 | UIMC1 | chr5 | 176409470 | - | LILRB1 | chr19 | 55142477 | + |
| 5CDS-intron | ENST00000377219 | ENST00000396315 | UIMC1 | chr5 | 176409470 | - | LILRB1 | chr19 | 55142477 | + |
| 5CDS-intron | ENST00000377219 | ENST00000462628 | UIMC1 | chr5 | 176409470 | - | LILRB1 | chr19 | 55142477 | + |
| 5CDS-intron | ENST00000506128 | ENST00000418536 | UIMC1 | chr5 | 176409470 | - | LILRB1 | chr19 | 55142477 | + |
| 5CDS-intron | ENST00000506128 | ENST00000448689 | UIMC1 | chr5 | 176409470 | - | LILRB1 | chr19 | 55142477 | + |
| 5CDS-intron | ENST00000506128 | ENST00000396321 | UIMC1 | chr5 | 176409470 | - | LILRB1 | chr19 | 55142477 | + |
| 5CDS-5UTR | ENST00000506128 | ENST00000396331 | UIMC1 | chr5 | 176409470 | - | LILRB1 | chr19 | 55142477 | + |
| 5CDS-5UTR | ENST00000506128 | ENST00000396327 | UIMC1 | chr5 | 176409470 | - | LILRB1 | chr19 | 55142477 | + |
| 5CDS-5UTR | ENST00000506128 | ENST00000434867 | UIMC1 | chr5 | 176409470 | - | LILRB1 | chr19 | 55142477 | + |
| 5CDS-5UTR | ENST00000506128 | ENST00000324602 | UIMC1 | chr5 | 176409470 | - | LILRB1 | chr19 | 55142477 | + |
| 5CDS-5UTR | ENST00000506128 | ENST00000396332 | UIMC1 | chr5 | 176409470 | - | LILRB1 | chr19 | 55142477 | + |
| 5CDS-5UTR | ENST00000506128 | ENST00000427581 | UIMC1 | chr5 | 176409470 | - | LILRB1 | chr19 | 55142477 | + |
| 5CDS-intron | ENST00000506128 | ENST00000396317 | UIMC1 | chr5 | 176409470 | - | LILRB1 | chr19 | 55142477 | + |
| 5CDS-intron | ENST00000506128 | ENST00000396315 | UIMC1 | chr5 | 176409470 | - | LILRB1 | chr19 | 55142477 | + |
| 5CDS-intron | ENST00000506128 | ENST00000462628 | UIMC1 | chr5 | 176409470 | - | LILRB1 | chr19 | 55142477 | + |
| 5CDS-intron | ENST00000511320 | ENST00000418536 | UIMC1 | chr5 | 176409470 | - | LILRB1 | chr19 | 55142477 | + |
| 5CDS-intron | ENST00000511320 | ENST00000448689 | UIMC1 | chr5 | 176409470 | - | LILRB1 | chr19 | 55142477 | + |
| 5CDS-intron | ENST00000511320 | ENST00000396321 | UIMC1 | chr5 | 176409470 | - | LILRB1 | chr19 | 55142477 | + |
| 5CDS-5UTR | ENST00000511320 | ENST00000396331 | UIMC1 | chr5 | 176409470 | - | LILRB1 | chr19 | 55142477 | + |
| 5CDS-5UTR | ENST00000511320 | ENST00000396327 | UIMC1 | chr5 | 176409470 | - | LILRB1 | chr19 | 55142477 | + |
| 5CDS-5UTR | ENST00000511320 | ENST00000434867 | UIMC1 | chr5 | 176409470 | - | LILRB1 | chr19 | 55142477 | + |
| 5CDS-5UTR | ENST00000511320 | ENST00000324602 | UIMC1 | chr5 | 176409470 | - | LILRB1 | chr19 | 55142477 | + |
| 5CDS-5UTR | ENST00000511320 | ENST00000396332 | UIMC1 | chr5 | 176409470 | - | LILRB1 | chr19 | 55142477 | + |
| 5CDS-5UTR | ENST00000511320 | ENST00000427581 | UIMC1 | chr5 | 176409470 | - | LILRB1 | chr19 | 55142477 | + |
| 5CDS-intron | ENST00000511320 | ENST00000396317 | UIMC1 | chr5 | 176409470 | - | LILRB1 | chr19 | 55142477 | + |
| 5CDS-intron | ENST00000511320 | ENST00000396315 | UIMC1 | chr5 | 176409470 | - | LILRB1 | chr19 | 55142477 | + |
| 5CDS-intron | ENST00000511320 | ENST00000462628 | UIMC1 | chr5 | 176409470 | - | LILRB1 | chr19 | 55142477 | + |
| intron-intron | ENST00000503273 | ENST00000418536 | UIMC1 | chr5 | 176409470 | - | LILRB1 | chr19 | 55142477 | + |
| intron-intron | ENST00000503273 | ENST00000448689 | UIMC1 | chr5 | 176409470 | - | LILRB1 | chr19 | 55142477 | + |
| intron-intron | ENST00000503273 | ENST00000396321 | UIMC1 | chr5 | 176409470 | - | LILRB1 | chr19 | 55142477 | + |
| intron-5UTR | ENST00000503273 | ENST00000396331 | UIMC1 | chr5 | 176409470 | - | LILRB1 | chr19 | 55142477 | + |
| intron-5UTR | ENST00000503273 | ENST00000396327 | UIMC1 | chr5 | 176409470 | - | LILRB1 | chr19 | 55142477 | + |
| intron-5UTR | ENST00000503273 | ENST00000434867 | UIMC1 | chr5 | 176409470 | - | LILRB1 | chr19 | 55142477 | + |
| intron-5UTR | ENST00000503273 | ENST00000324602 | UIMC1 | chr5 | 176409470 | - | LILRB1 | chr19 | 55142477 | + |
| intron-5UTR | ENST00000503273 | ENST00000396332 | UIMC1 | chr5 | 176409470 | - | LILRB1 | chr19 | 55142477 | + |
| intron-5UTR | ENST00000503273 | ENST00000427581 | UIMC1 | chr5 | 176409470 | - | LILRB1 | chr19 | 55142477 | + |
| intron-intron | ENST00000503273 | ENST00000396317 | UIMC1 | chr5 | 176409470 | - | LILRB1 | chr19 | 55142477 | + |
| intron-intron | ENST00000503273 | ENST00000396315 | UIMC1 | chr5 | 176409470 | - | LILRB1 | chr19 | 55142477 | + |
| intron-intron | ENST00000503273 | ENST00000462628 | UIMC1 | chr5 | 176409470 | - | LILRB1 | chr19 | 55142477 | + |
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FusionProtFeatures for UIMC1_LILRB1 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| UIMC1 | LILRB1 |