|
||||||
|
 | |
| |
| |
| |
| |
|
Fusion gene ID: 40701 |
FusionGeneSummary for UGDH_PDS5A |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: UGDH_PDS5A | Fusion gene ID: 40701 | Hgene | Tgene | Gene symbol | UGDH | PDS5A | Gene ID | 7358 | 23244 |
| Gene name | UDP-glucose 6-dehydrogenase | PDS5 cohesin associated factor A | |
| Synonyms | GDH|UDP-GlcDH|UDPGDH|UGD | PIG54|SCC-112|SCC112 | |
| Cytomap | 4p14 | 4p14 | |
| Type of gene | protein-coding | protein-coding | |
| Description | UDP-glucose 6-dehydrogenaseUDP-Glc dehydrogenaseUDP-glucose dehydrogenaseuridine diphospho-glucose dehydrogenase | sister chromatid cohesion protein PDS5 homolog APDS5, regulator of cohesion maintenance, homolog Acell proliferation-inducing gene 54 proteinsister chromatid cohesion protein 112 | |
| Modification date | 20180523 | 20180523 | |
| UniProtAcc | O60701 | Q29RF7 | |
| Ensembl transtripts involved in fusion gene | ENST00000316423, ENST00000501493, ENST00000506179, ENST00000507089, ENST00000515398, | ENST00000303538, ENST00000503396, | |
| Fusion gene scores | * DoF score | 3 X 2 X 3=18 | 6 X 7 X 4=168 |
| # samples | 3 | 7 | |
| ** MAII score | log2(3/18*10)=0.736965594166206 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | log2(7/168*10)=-1.26303440583379 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: UGDH [Title/Abstract] AND PDS5A [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | LD | STAD | TCGA-VQ-A922-01A | UGDH | chr4 | 39528903 | - | PDS5A | chr4 | 39910160 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| 5UTR-3CDS | ENST00000316423 | ENST00000303538 | UGDH | chr4 | 39528903 | - | PDS5A | chr4 | 39910160 | - |
| 5UTR-3CDS | ENST00000316423 | ENST00000503396 | UGDH | chr4 | 39528903 | - | PDS5A | chr4 | 39910160 | - |
| 5UTR-3CDS | ENST00000501493 | ENST00000303538 | UGDH | chr4 | 39528903 | - | PDS5A | chr4 | 39910160 | - |
| 5UTR-3CDS | ENST00000501493 | ENST00000503396 | UGDH | chr4 | 39528903 | - | PDS5A | chr4 | 39910160 | - |
| intron-3CDS | ENST00000506179 | ENST00000303538 | UGDH | chr4 | 39528903 | - | PDS5A | chr4 | 39910160 | - |
| intron-3CDS | ENST00000506179 | ENST00000503396 | UGDH | chr4 | 39528903 | - | PDS5A | chr4 | 39910160 | - |
| 5UTR-3CDS | ENST00000507089 | ENST00000303538 | UGDH | chr4 | 39528903 | - | PDS5A | chr4 | 39910160 | - |
| 5UTR-3CDS | ENST00000507089 | ENST00000503396 | UGDH | chr4 | 39528903 | - | PDS5A | chr4 | 39910160 | - |
| intron-3CDS | ENST00000515398 | ENST00000303538 | UGDH | chr4 | 39528903 | - | PDS5A | chr4 | 39910160 | - |
| intron-3CDS | ENST00000515398 | ENST00000503396 | UGDH | chr4 | 39528903 | - | PDS5A | chr4 | 39910160 | - |
Top |
FusionProtFeatures for UGDH_PDS5A |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| UGDH | PDS5A |