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Fusion gene ID: 40659

FusionGeneSummary for UCHL5_TARS2

Fusion gene summary

Fusion gene information	Fusion gene name: UCHL5_TARS2
	Fusion gene ID: 40659
		Hgene	Tgene
	Gene symbol	UCHL5	TARS2
	Gene ID	51377	80222
	Gene name	ubiquitin C-terminal hydrolase L5	threonyl-tRNA synthetase 2, mitochondrial
	Synonyms	CGI-70\|INO80R\|UCH-L5\|UCH37	COXPD21\|TARSL1\|thrRS
	Cytomap	1q31.2	1q21.2
	Type of gene	protein-coding	protein-coding
	Description	ubiquitin carboxyl-terminal hydrolase isozyme L5INO80 complex subunit Rubiquitin C-terminal hydrolase UCH37ubiquitin carboxyl-terminal esterase L5ubiquitin carboxyl-terminal hydrolase L5ubiquitin thioesterase L5	threonine--tRNA ligase, mitochondrialthreonyl-tRNA synthetase 2, mitochondrial (putative)threonyl-tRNA synthetase-like 1
	Modification date	20180527	20180523
	UniProtAcc	Q9Y5K5	Q9BW92
	Ensembl transtripts involved in fusion gene	ENST00000367455, ENST00000367454, ENST00000367451, ENST00000367448, ENST00000367449, ENST00000367452, ENST00000530098, ENST00000483156,	ENST00000438568, ENST00000369054, ENST00000369064, ENST00000606933, ENST00000463555,
Fusion gene scores	* DoF score	4 X 3 X 3=36	5 X 3 X 4=60
	# samples	4	5
	** MAII score	log2(4/36*10)=0.15200309344505 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0	log2(5/60*10)=-0.263034405833794 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context	PubMed: UCHL5 [Title/Abstract] AND TARS2 [Title/Abstract] AND fusion [Title/Abstract]
Functional or gene categories assigned by FusionGDB annotation

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Hgene	UCHL5	GO:0016579	protein deubiquitination	18922472

Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Data type	Source	Cancer type	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
TCGA	LD	SKCM	TCGA-EB-A42Z-01A	UCHL5	chr1	192990227	-	TARS2	chr1	150468958	+

* LD: Li Ding group's fusion gene list
RV: Roel Verhaak group's fusion gene list
ChiTaRs fusion database

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
5CDS-3UTR	ENST00000367455	ENST00000438568	UCHL5	chr1	192990227	-	TARS2	chr1	150468958	+
5CDS-intron	ENST00000367455	ENST00000369054	UCHL5	chr1	192990227	-	TARS2	chr1	150468958	+
5CDS-intron	ENST00000367455	ENST00000369064	UCHL5	chr1	192990227	-	TARS2	chr1	150468958	+
5CDS-intron	ENST00000367455	ENST00000606933	UCHL5	chr1	192990227	-	TARS2	chr1	150468958	+
5CDS-intron	ENST00000367455	ENST00000463555	UCHL5	chr1	192990227	-	TARS2	chr1	150468958	+
5CDS-3UTR	ENST00000367454	ENST00000438568	UCHL5	chr1	192990227	-	TARS2	chr1	150468958	+
5CDS-intron	ENST00000367454	ENST00000369054	UCHL5	chr1	192990227	-	TARS2	chr1	150468958	+
5CDS-intron	ENST00000367454	ENST00000369064	UCHL5	chr1	192990227	-	TARS2	chr1	150468958	+
5CDS-intron	ENST00000367454	ENST00000606933	UCHL5	chr1	192990227	-	TARS2	chr1	150468958	+
5CDS-intron	ENST00000367454	ENST00000463555	UCHL5	chr1	192990227	-	TARS2	chr1	150468958	+
5CDS-3UTR	ENST00000367451	ENST00000438568	UCHL5	chr1	192990227	-	TARS2	chr1	150468958	+
5CDS-intron	ENST00000367451	ENST00000369054	UCHL5	chr1	192990227	-	TARS2	chr1	150468958	+
5CDS-intron	ENST00000367451	ENST00000369064	UCHL5	chr1	192990227	-	TARS2	chr1	150468958	+
5CDS-intron	ENST00000367451	ENST00000606933	UCHL5	chr1	192990227	-	TARS2	chr1	150468958	+
5CDS-intron	ENST00000367451	ENST00000463555	UCHL5	chr1	192990227	-	TARS2	chr1	150468958	+
5CDS-3UTR	ENST00000367448	ENST00000438568	UCHL5	chr1	192990227	-	TARS2	chr1	150468958	+
5CDS-intron	ENST00000367448	ENST00000369054	UCHL5	chr1	192990227	-	TARS2	chr1	150468958	+
5CDS-intron	ENST00000367448	ENST00000369064	UCHL5	chr1	192990227	-	TARS2	chr1	150468958	+
5CDS-intron	ENST00000367448	ENST00000606933	UCHL5	chr1	192990227	-	TARS2	chr1	150468958	+
5CDS-intron	ENST00000367448	ENST00000463555	UCHL5	chr1	192990227	-	TARS2	chr1	150468958	+
5CDS-3UTR	ENST00000367449	ENST00000438568	UCHL5	chr1	192990227	-	TARS2	chr1	150468958	+
5CDS-intron	ENST00000367449	ENST00000369054	UCHL5	chr1	192990227	-	TARS2	chr1	150468958	+
5CDS-intron	ENST00000367449	ENST00000369064	UCHL5	chr1	192990227	-	TARS2	chr1	150468958	+
5CDS-intron	ENST00000367449	ENST00000606933	UCHL5	chr1	192990227	-	TARS2	chr1	150468958	+
5CDS-intron	ENST00000367449	ENST00000463555	UCHL5	chr1	192990227	-	TARS2	chr1	150468958	+
5CDS-3UTR	ENST00000367452	ENST00000438568	UCHL5	chr1	192990227	-	TARS2	chr1	150468958	+
5CDS-intron	ENST00000367452	ENST00000369054	UCHL5	chr1	192990227	-	TARS2	chr1	150468958	+
5CDS-intron	ENST00000367452	ENST00000369064	UCHL5	chr1	192990227	-	TARS2	chr1	150468958	+
5CDS-intron	ENST00000367452	ENST00000606933	UCHL5	chr1	192990227	-	TARS2	chr1	150468958	+
5CDS-intron	ENST00000367452	ENST00000463555	UCHL5	chr1	192990227	-	TARS2	chr1	150468958	+
5CDS-3UTR	ENST00000530098	ENST00000438568	UCHL5	chr1	192990227	-	TARS2	chr1	150468958	+
5CDS-intron	ENST00000530098	ENST00000369054	UCHL5	chr1	192990227	-	TARS2	chr1	150468958	+
5CDS-intron	ENST00000530098	ENST00000369064	UCHL5	chr1	192990227	-	TARS2	chr1	150468958	+
5CDS-intron	ENST00000530098	ENST00000606933	UCHL5	chr1	192990227	-	TARS2	chr1	150468958	+
5CDS-intron	ENST00000530098	ENST00000463555	UCHL5	chr1	192990227	-	TARS2	chr1	150468958	+
intron-3UTR	ENST00000483156	ENST00000438568	UCHL5	chr1	192990227	-	TARS2	chr1	150468958	+
intron-intron	ENST00000483156	ENST00000369054	UCHL5	chr1	192990227	-	TARS2	chr1	150468958	+
intron-intron	ENST00000483156	ENST00000369064	UCHL5	chr1	192990227	-	TARS2	chr1	150468958	+
intron-intron	ENST00000483156	ENST00000606933	UCHL5	chr1	192990227	-	TARS2	chr1	150468958	+
intron-intron	ENST00000483156	ENST00000463555	UCHL5	chr1	192990227	-	TARS2	chr1	150468958	+

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FusionProtFeatures for UCHL5_TARS2

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
UCHL5 Q9Y5K5	TARS2 Q9BW92

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Fusion gene ID: 40659

FusionGeneSummary for UCHL5_TARS2

FusionProtFeatures for UCHL5_TARS2