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Fusion gene ID: 40563 |
FusionGeneSummary for UBN1_SRRM2 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: UBN1_SRRM2 | Fusion gene ID: 40563 | Hgene | Tgene | Gene symbol | UBN1 | SRRM2 | Gene ID | 29855 | 23524 |
| Gene name | ubinuclein 1 | serine/arginine repetitive matrix 2 | |
| Synonyms | VT|VT4 | 300-KD|CWF21|Cwc21|HSPC075|SRL300|SRm300 | |
| Cytomap | 16p13.3 | 16p13.3 | |
| Type of gene | protein-coding | protein-coding | |
| Description | ubinuclein-1HIRA-binding proteinubiquitously expressed nuclear protein | serine/arginine repetitive matrix protein 2300 kDa nuclear matrix antigenRNA binding proteinSR-related nuclear matrix protein of 300 kDaser/Arg-related nuclear matrix protein of 300 kDaserine/arginine-rich splicing factor-related nuclear matrix prote | |
| Modification date | 20180519 | 20180522 | |
| UniProtAcc | Q9NPG3 | Q9UQ35 | |
| Ensembl transtripts involved in fusion gene | ENST00000262376, ENST00000545171, ENST00000590769, ENST00000396658, ENST00000585857, | ENST00000301740, ENST00000574593, | |
| Fusion gene scores | * DoF score | 4 X 5 X 5=100 | 10 X 17 X 4=680 |
| # samples | 6 | 21 | |
| ** MAII score | log2(6/100*10)=-0.736965594166206 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(21/680*10)=-1.69514541847158 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: UBN1 [Title/Abstract] AND SRRM2 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | UBN1 | GO:0006336 | DNA replication-independent nucleosome assembly | 14718166 |
| Tgene | SRRM2 | GO:0000398 | mRNA splicing, via spliceosome | 28076346 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | LD | OV | TCGA-29-1694-01A | UBN1 | chr16 | 4897340 | + | SRRM2 | chr16 | 2819933 | + |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| intron-intron | ENST00000262376 | ENST00000301740 | UBN1 | chr16 | 4897340 | + | SRRM2 | chr16 | 2819933 | + |
| intron-3UTR | ENST00000262376 | ENST00000574593 | UBN1 | chr16 | 4897340 | + | SRRM2 | chr16 | 2819933 | + |
| intron-intron | ENST00000545171 | ENST00000301740 | UBN1 | chr16 | 4897340 | + | SRRM2 | chr16 | 2819933 | + |
| intron-3UTR | ENST00000545171 | ENST00000574593 | UBN1 | chr16 | 4897340 | + | SRRM2 | chr16 | 2819933 | + |
| intron-intron | ENST00000590769 | ENST00000301740 | UBN1 | chr16 | 4897340 | + | SRRM2 | chr16 | 2819933 | + |
| intron-3UTR | ENST00000590769 | ENST00000574593 | UBN1 | chr16 | 4897340 | + | SRRM2 | chr16 | 2819933 | + |
| intron-intron | ENST00000396658 | ENST00000301740 | UBN1 | chr16 | 4897340 | + | SRRM2 | chr16 | 2819933 | + |
| intron-3UTR | ENST00000396658 | ENST00000574593 | UBN1 | chr16 | 4897340 | + | SRRM2 | chr16 | 2819933 | + |
| intron-intron | ENST00000585857 | ENST00000301740 | UBN1 | chr16 | 4897340 | + | SRRM2 | chr16 | 2819933 | + |
| intron-3UTR | ENST00000585857 | ENST00000574593 | UBN1 | chr16 | 4897340 | + | SRRM2 | chr16 | 2819933 | + |
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FusionProtFeatures for UBN1_SRRM2 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| UBN1 | SRRM2 |