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Fusion gene ID: 4056

FusionGeneSummary for BCL7C_TSC22D1

Fusion gene summary

Fusion gene information	Fusion gene name: BCL7C_TSC22D1
	Fusion gene ID: 4056
		Hgene	Tgene
	Gene symbol	BCL7C	TSC22D1
	Gene ID	9274	8848
	Gene name	BCL tumor suppressor 7C	TSC22 domain family member 1
	Synonyms	-	Ptg-2\|TGFB1I4\|TSC22
	Cytomap	16p11.2	13q14.11
	Type of gene	protein-coding	protein-coding
	Description	B-cell CLL/lymphoma 7 protein family member CB-cell CLL/lymphoma 7C	TSC22 domain family protein 1TGFB-stimulated clone 22 homologTGFbeta-stimulated clone 22cerebral protein 2regulatory protein TSC-22transcriptional regulator TSC-22transforming growth factor beta-1-induced transcript 4 proteintransforming growth fac
	Modification date	20180519	20180522
	UniProtAcc	Q8WUZ0	Q15714
	Ensembl transtripts involved in fusion gene	ENST00000380317, ENST00000576194, ENST00000215115,	ENST00000458659, ENST00000501704, ENST00000261489, ENST00000460842,
Fusion gene scores	* DoF score	2 X 2 X 2=8	8 X 10 X 4=320
	# samples	2	11
	** MAII score	log2(2/8*10)=1.32192809488736	log2(11/320*10)=-1.5405683813627 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context	PubMed: BCL7C [Title/Abstract] AND TSC22D1 [Title/Abstract] AND fusion [Title/Abstract]
Functional or gene categories assigned by FusionGDB annotation

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner

Gene

GO ID

GO term

PubMed ID

Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Data type	Source	Cancer type	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChiTaRS3.1			AI342324	BCL7C	chr16	30899231	+	TSC22D1	chr13	45008748	+

* LD: Li Ding group's fusion gene list
RV: Roel Verhaak group's fusion gene list
ChiTaRs fusion database

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
intron-3UTR	ENST00000380317	ENST00000458659	BCL7C	chr16	30899231	+	TSC22D1	chr13	45008748	+
intron-intron	ENST00000380317	ENST00000501704	BCL7C	chr16	30899231	+	TSC22D1	chr13	45008748	+
intron-3UTR	ENST00000380317	ENST00000261489	BCL7C	chr16	30899231	+	TSC22D1	chr13	45008748	+
intron-intron	ENST00000380317	ENST00000460842	BCL7C	chr16	30899231	+	TSC22D1	chr13	45008748	+
intron-3UTR	ENST00000576194	ENST00000458659	BCL7C	chr16	30899231	+	TSC22D1	chr13	45008748	+
intron-intron	ENST00000576194	ENST00000501704	BCL7C	chr16	30899231	+	TSC22D1	chr13	45008748	+
intron-3UTR	ENST00000576194	ENST00000261489	BCL7C	chr16	30899231	+	TSC22D1	chr13	45008748	+
intron-intron	ENST00000576194	ENST00000460842	BCL7C	chr16	30899231	+	TSC22D1	chr13	45008748	+
intron-3UTR	ENST00000215115	ENST00000458659	BCL7C	chr16	30899231	+	TSC22D1	chr13	45008748	+
intron-intron	ENST00000215115	ENST00000501704	BCL7C	chr16	30899231	+	TSC22D1	chr13	45008748	+
intron-3UTR	ENST00000215115	ENST00000261489	BCL7C	chr16	30899231	+	TSC22D1	chr13	45008748	+
intron-intron	ENST00000215115	ENST00000460842	BCL7C	chr16	30899231	+	TSC22D1	chr13	45008748	+

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FusionProtFeatures for BCL7C_TSC22D1

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
BCL7C Q8WUZ0	TSC22D1 Q15714

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Fusion gene ID: 4056

FusionGeneSummary for BCL7C_TSC22D1

FusionProtFeatures for BCL7C_TSC22D1