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Fusion gene ID: 40547 |
FusionGeneSummary for UBL3_CDK8 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: UBL3_CDK8 | Fusion gene ID: 40547 | Hgene | Tgene | Gene symbol | UBL3 | CDK8 | Gene ID | 5412 | 1024 |
| Gene name | ubiquitin like 3 | cyclin dependent kinase 8 | |
| Synonyms | HCG-1|PNSC1 | K35 | |
| Cytomap | 13q12.3 | 13q12.13 | |
| Type of gene | protein-coding | protein-coding | |
| Description | ubiquitin-like protein 3MUBhsMUBmembrane-anchored ubiquitin-fold proteinprotein HCG-1 | cyclin-dependent kinase 8CDK8 protein kinasecell division protein kinase 8mediator complex subunit CDK8mediator of RNA polymerase II transcription subunit CDK8protein kinase K35 | |
| Modification date | 20180519 | 20180523 | |
| UniProtAcc | O95164 | P49336 | |
| Ensembl transtripts involved in fusion gene | ENST00000380680, | ENST00000381527, ENST00000536792, ENST00000480323, | |
| Fusion gene scores | * DoF score | 8 X 3 X 4=96 | 3 X 2 X 3=18 |
| # samples | 8 | 3 | |
| ** MAII score | log2(8/96*10)=-0.263034405833794 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(3/18*10)=0.736965594166206 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | |
| Context | PubMed: UBL3 [Title/Abstract] AND CDK8 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | RV | BLCA | TCGA-DK-AA6P-01A | UBL3 | chr13 | 30423649 | - | CDK8 | chr13 | 26911704 | + |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| Frame-shift | ENST00000380680 | ENST00000381527 | UBL3 | chr13 | 30423649 | - | CDK8 | chr13 | 26911704 | + |
| Frame-shift | ENST00000380680 | ENST00000536792 | UBL3 | chr13 | 30423649 | - | CDK8 | chr13 | 26911704 | + |
| 5CDS-intron | ENST00000380680 | ENST00000480323 | UBL3 | chr13 | 30423649 | - | CDK8 | chr13 | 26911704 | + |
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FusionProtFeatures for UBL3_CDK8 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| UBL3 | CDK8 |