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Fusion gene ID: 40521 |
FusionGeneSummary for UBE3C_CCND1 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: UBE3C_CCND1 | Fusion gene ID: 40521 | Hgene | Tgene | Gene symbol | UBE3C | CCND1 | Gene ID | 9690 | 595 |
| Gene name | ubiquitin protein ligase E3C | cyclin D1 | |
| Synonyms | HECTH2 | BCL1|D11S287E|PRAD1|U21B31 | |
| Cytomap | 7q36.3 | 11q13.3 | |
| Type of gene | protein-coding | protein-coding | |
| Description | ubiquitin-protein ligase E3CHECT-type ubiquitin transferase E3Cubiquitin-protein isopeptide ligase (E3) | G1/S-specific cyclin-D1B-cell CLL/lymphoma 1B-cell lymphoma 1 proteinBCL-1 oncogenePRAD1 oncogene | |
| Modification date | 20180523 | 20180527 | |
| UniProtAcc | Q15386 | P24385 | |
| Ensembl transtripts involved in fusion gene | ENST00000348165, ENST00000389103, | ENST00000227507, ENST00000536559, | |
| Fusion gene scores | * DoF score | 10 X 11 X 8=880 | 10 X 10 X 4=400 |
| # samples | 14 | 10 | |
| ** MAII score | log2(14/880*10)=-2.65207669657969 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(10/400*10)=-2 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: UBE3C [Title/Abstract] AND CCND1 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | UBE3C | GO:0000209 | protein polyubiquitination | 11278995 |
| Tgene | CCND1 | GO:0000082 | G1/S transition of mitotic cell cycle | 19412162 |
| Tgene | CCND1 | GO:0000122 | negative regulation of transcription by RNA polymerase II | 16569215|18417529 |
| Tgene | CCND1 | GO:0001934 | positive regulation of protein phosphorylation | 8114739 |
| Tgene | CCND1 | GO:0006974 | cellular response to DNA damage stimulus | 19412162 |
| Tgene | CCND1 | GO:0010971 | positive regulation of G2/M transition of mitotic cell cycle | 19124461 |
| Tgene | CCND1 | GO:0031571 | mitotic G1 DNA damage checkpoint | 19412162 |
| Tgene | CCND1 | GO:0044321 | response to leptin | 17344214 |
| Tgene | CCND1 | GO:0045737 | positive regulation of cyclin-dependent protein serine/threonine kinase activity | 8114739 |
| Tgene | CCND1 | GO:0070141 | response to UV-A | 18483258 |
| Tgene | CCND1 | GO:0071157 | negative regulation of cell cycle arrest | 19124461 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| ChiTaRS3.1 | BF736662 | UBE3C | chr7 | 157036030 | + | CCND1 | chr11 | 69467979 | + |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| intron-3UTR | ENST00000348165 | ENST00000227507 | UBE3C | chr7 | 157036030 | + | CCND1 | chr11 | 69467979 | + |
| intron-intron | ENST00000348165 | ENST00000536559 | UBE3C | chr7 | 157036030 | + | CCND1 | chr11 | 69467979 | + |
| intron-3UTR | ENST00000389103 | ENST00000227507 | UBE3C | chr7 | 157036030 | + | CCND1 | chr11 | 69467979 | + |
| intron-intron | ENST00000389103 | ENST00000536559 | UBE3C | chr7 | 157036030 | + | CCND1 | chr11 | 69467979 | + |
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FusionProtFeatures for UBE3C_CCND1 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| UBE3C | CCND1 |