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Fusion gene ID: 40506 |
FusionGeneSummary for UBE2Z_EPS15 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: UBE2Z_EPS15 | Fusion gene ID: 40506 | Hgene | Tgene | Gene symbol | UBE2Z | EPS15 | Gene ID | 65264 | 2060 |
| Gene name | ubiquitin conjugating enzyme E2 Z | epidermal growth factor receptor pathway substrate 15 | |
| Synonyms | HOYS7|USE1 | AF-1P|AF1P|MLLT5 | |
| Cytomap | 17q21.32 | 1p32.3 | |
| Type of gene | protein-coding | protein-coding | |
| Description | ubiquitin-conjugating enzyme E2 ZE2 ubiquitin-conjugating enzyme ZUBA6-specific enzyme E2uba6-specific E2 conjugating enzyme 1ubiquitin carrier protein Zubiquitin conjugating enzyme E2Zubiquitin-protein ligase Z | epidermal growth factor receptor substrate 15ALL1 fused gene from chromosome 1protein AF-1p | |
| Modification date | 20180527 | 20180522 | |
| UniProtAcc | Q9H832 | P42566 | |
| Ensembl transtripts involved in fusion gene | ENST00000360943, | ENST00000371730, ENST00000371733, ENST00000396122, ENST00000493793, | |
| Fusion gene scores | * DoF score | 8 X 8 X 4=256 | 5 X 4 X 4=80 |
| # samples | 10 | 6 | |
| ** MAII score | log2(10/256*10)=-1.35614381022528 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(6/80*10)=-0.415037499278844 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: UBE2Z [Title/Abstract] AND EPS15 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | UBE2Z | GO:0043065 | positive regulation of apoptotic process | 17464193 |
| Tgene | EPS15 | GO:0048268 | clathrin coat assembly | 12807910 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| ChiTaRS3.1 | BU930424 | UBE2Z | chr17 | 47003395 | + | EPS15 | chr1 | 52220588 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| intron-intron | ENST00000360943 | ENST00000371730 | UBE2Z | chr17 | 47003395 | + | EPS15 | chr1 | 52220588 | - |
| intron-intron | ENST00000360943 | ENST00000371733 | UBE2Z | chr17 | 47003395 | + | EPS15 | chr1 | 52220588 | - |
| intron-intron | ENST00000360943 | ENST00000396122 | UBE2Z | chr17 | 47003395 | + | EPS15 | chr1 | 52220588 | - |
| intron-intron | ENST00000360943 | ENST00000493793 | UBE2Z | chr17 | 47003395 | + | EPS15 | chr1 | 52220588 | - |
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FusionProtFeatures for UBE2Z_EPS15 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| UBE2Z | EPS15 |