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Fusion gene ID: 40459 |
FusionGeneSummary for UBE2L3_LLGL2 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: UBE2L3_LLGL2 | Fusion gene ID: 40459 | Hgene | Tgene | Gene symbol | UBE2L3 | LLGL2 | Gene ID | 7332 | 3993 |
| Gene name | ubiquitin conjugating enzyme E2 L3 | LLGL2, scribble cell polarity complex component | |
| Synonyms | E2-F1|L-UBC|UBCH7|UbcM4 | HGL|Hugl-2|LGL2 | |
| Cytomap | 22q11.21 | 17q25.1 | |
| Type of gene | protein-coding | protein-coding | |
| Description | ubiquitin-conjugating enzyme E2 L3E2 ubiquitin-conjugating enzyme L3ubiquitin carrier protein L3ubiquitin conjugating enzyme E2L 3ubiquitin-conjugating enzyme E2-F1ubiquitin-conjugating enzyme UBCH7ubiquitin-protein ligase L3 | lethal(2) giant larvae protein homolog 2human giant larvae homologlethal giant larvae homolog 2, scribble cell polarity complex component | |
| Modification date | 20180523 | 20180523 | |
| UniProtAcc | P68036 | Q6P1M3 | |
| Ensembl transtripts involved in fusion gene | ENST00000458578, ENST00000342192, ENST00000545681, | ENST00000167462, ENST00000375227, ENST00000392550, ENST00000578363, ENST00000577200, | |
| Fusion gene scores | * DoF score | 4 X 2 X 4=32 | 6 X 5 X 5=150 |
| # samples | 4 | 8 | |
| ** MAII score | log2(4/32*10)=0.321928094887362 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | log2(8/150*10)=-0.906890595608519 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: UBE2L3 [Title/Abstract] AND LLGL2 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | UBE2L3 | GO:0000209 | protein polyubiquitination | 10888878|14765125 |
| Hgene | UBE2L3 | GO:0006355 | regulation of transcription, DNA-templated | 17003263 |
| Hgene | UBE2L3 | GO:0016567 | protein ubiquitination | 9990509|21532592 |
| Hgene | UBE2L3 | GO:0070979 | protein K11-linked ubiquitination | 20061386 |
| Hgene | UBE2L3 | GO:0071385 | cellular response to glucocorticoid stimulus | 17003263 |
| Tgene | LLGL2 | GO:0032878 | regulation of establishment or maintenance of cell polarity | 12725730 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | LD | UCEC | TCGA-AJ-A6NU-01A | UBE2L3 | chr22 | 21922060 | + | LLGL2 | chr17 | 73539478 | + |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| intron-5UTR | ENST00000458578 | ENST00000167462 | UBE2L3 | chr22 | 21922060 | + | LLGL2 | chr17 | 73539478 | + |
| intron-5UTR | ENST00000458578 | ENST00000375227 | UBE2L3 | chr22 | 21922060 | + | LLGL2 | chr17 | 73539478 | + |
| intron-5UTR | ENST00000458578 | ENST00000392550 | UBE2L3 | chr22 | 21922060 | + | LLGL2 | chr17 | 73539478 | + |
| intron-5UTR | ENST00000458578 | ENST00000578363 | UBE2L3 | chr22 | 21922060 | + | LLGL2 | chr17 | 73539478 | + |
| intron-5UTR | ENST00000458578 | ENST00000577200 | UBE2L3 | chr22 | 21922060 | + | LLGL2 | chr17 | 73539478 | + |
| 5CDS-5UTR | ENST00000342192 | ENST00000167462 | UBE2L3 | chr22 | 21922060 | + | LLGL2 | chr17 | 73539478 | + |
| 5CDS-5UTR | ENST00000342192 | ENST00000375227 | UBE2L3 | chr22 | 21922060 | + | LLGL2 | chr17 | 73539478 | + |
| 5CDS-5UTR | ENST00000342192 | ENST00000392550 | UBE2L3 | chr22 | 21922060 | + | LLGL2 | chr17 | 73539478 | + |
| 5CDS-5UTR | ENST00000342192 | ENST00000578363 | UBE2L3 | chr22 | 21922060 | + | LLGL2 | chr17 | 73539478 | + |
| 5CDS-5UTR | ENST00000342192 | ENST00000577200 | UBE2L3 | chr22 | 21922060 | + | LLGL2 | chr17 | 73539478 | + |
| 5CDS-5UTR | ENST00000545681 | ENST00000167462 | UBE2L3 | chr22 | 21922060 | + | LLGL2 | chr17 | 73539478 | + |
| 5CDS-5UTR | ENST00000545681 | ENST00000375227 | UBE2L3 | chr22 | 21922060 | + | LLGL2 | chr17 | 73539478 | + |
| 5CDS-5UTR | ENST00000545681 | ENST00000392550 | UBE2L3 | chr22 | 21922060 | + | LLGL2 | chr17 | 73539478 | + |
| 5CDS-5UTR | ENST00000545681 | ENST00000578363 | UBE2L3 | chr22 | 21922060 | + | LLGL2 | chr17 | 73539478 | + |
| 5CDS-5UTR | ENST00000545681 | ENST00000577200 | UBE2L3 | chr22 | 21922060 | + | LLGL2 | chr17 | 73539478 | + |
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FusionProtFeatures for UBE2L3_LLGL2 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| UBE2L3 | LLGL2 |