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Fusion gene ID: 40449

FusionGeneSummary for UBE2K_FAM216B

Fusion gene summary

Fusion gene information	Fusion gene name: UBE2K_FAM216B
	Fusion gene ID: 40449
		Hgene	Tgene
	Gene symbol	UBE2K	FAM216B
	Gene ID	3093	144809
	Gene name	ubiquitin conjugating enzyme E2 K	family with sequence similarity 216 member B
	Synonyms	E2-25K\|HIP2\|HYPG\|LIG\|UBC1	C13orf30
	Cytomap	4p14	13q14.11
	Type of gene	protein-coding	protein-coding
	Description	ubiquitin-conjugating enzyme E2 KE2 ubiquitin-conjugating enzyme KE2(25K)HIP-2huntingtin-interacting protein 2ubiquitin carrier proteinubiquitin conjugating enzyme E2Kubiquitin-conjugating enzyme E2(25K)ubiquitin-conjugating enzyme E2-25 KDAubiqu	protein FAM216B
	Modification date	20180523	20180329
	UniProtAcc	P61086	Q8N7L0
	Ensembl transtripts involved in fusion gene	ENST00000261427, ENST00000295963, ENST00000438068, ENST00000503368, ENST00000445950,	ENST00000537894, ENST00000313851,
Fusion gene scores	* DoF score	9 X 6 X 9=486	1 X 1 X 1=1
	# samples	10	1
	** MAII score	log2(10/486*10)=-2.28095631383106 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(1/1*10)=3.32192809488736
Context	PubMed: UBE2K [Title/Abstract] AND FAM216B [Title/Abstract] AND fusion [Title/Abstract]
Functional or gene categories assigned by FusionGDB annotation

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Hgene	UBE2K	GO:0010800	positive regulation of peptidyl-threonine phosphorylation	24882218
Hgene	UBE2K	GO:0010994	free ubiquitin chain polymerization	24882218
Hgene	UBE2K	GO:0070936	protein K48-linked ubiquitination	20061386

Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Data type	Source	Cancer type	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
TCGA	LD	LUAD	TCGA-86-A4P7-01A	UBE2K	chr4	39700010	+	FAM216B	chr13	43360899	+

* LD: Li Ding group's fusion gene list
RV: Roel Verhaak group's fusion gene list
ChiTaRs fusion database

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
In-frame	ENST00000261427	ENST00000537894	UBE2K	chr4	39700010	+	FAM216B	chr13	43360899	+
In-frame	ENST00000261427	ENST00000313851	UBE2K	chr4	39700010	+	FAM216B	chr13	43360899	+
In-frame	ENST00000295963	ENST00000537894	UBE2K	chr4	39700010	+	FAM216B	chr13	43360899	+
In-frame	ENST00000295963	ENST00000313851	UBE2K	chr4	39700010	+	FAM216B	chr13	43360899	+
intron-3CDS	ENST00000438068	ENST00000537894	UBE2K	chr4	39700010	+	FAM216B	chr13	43360899	+
intron-3CDS	ENST00000438068	ENST00000313851	UBE2K	chr4	39700010	+	FAM216B	chr13	43360899	+
In-frame	ENST00000503368	ENST00000537894	UBE2K	chr4	39700010	+	FAM216B	chr13	43360899	+
In-frame	ENST00000503368	ENST00000313851	UBE2K	chr4	39700010	+	FAM216B	chr13	43360899	+
In-frame	ENST00000445950	ENST00000537894	UBE2K	chr4	39700010	+	FAM216B	chr13	43360899	+
In-frame	ENST00000445950	ENST00000313851	UBE2K	chr4	39700010	+	FAM216B	chr13	43360899	+

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FusionProtFeatures for UBE2K_FAM216B

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
UBE2K P61086	FAM216B Q8N7L0

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Fusion gene ID: 40449

FusionGeneSummary for UBE2K_FAM216B

FusionProtFeatures for UBE2K_FAM216B