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Fusion gene ID: 40399

FusionGeneSummary for UBE2D3_NRF1

Fusion gene summary

Fusion gene information	Fusion gene name: UBE2D3_NRF1
	Fusion gene ID: 40399
		Hgene	Tgene
	Gene symbol	UBE2D3	NRF1
	Gene ID	7323	4899
	Gene name	ubiquitin conjugating enzyme E2 D3	nuclear respiratory factor 1
	Synonyms	E2(17)KB3\|UBC4/5\|UBCH5C	ALPHA-PAL
	Cytomap	4q24	7q32.2
	Type of gene	protein-coding	protein-coding
	Description	ubiquitin-conjugating enzyme E2 D3(E3-independent) E2 ubiquitin-conjugating enzyme D3E2 ubiquitin-conjugating enzyme D3ubiquitin carrier protein D3ubiquitin conjugating enzyme E2D 3ubiquitin-conjugating enzyme E2(17)KB 3ubiquitin-conjugating enzyme	nuclear respiratory factor 1alpha palindromic-binding protein
	Modification date	20180523	20180523
	UniProtAcc	P61077	Q16656
	Ensembl transtripts involved in fusion gene	ENST00000453744, ENST00000394801, ENST00000394803, ENST00000394804, ENST00000343106, ENST00000321805, ENST00000350435, ENST00000338145, ENST00000349311, ENST00000504211, ENST00000357194, ENST00000505207, ENST00000507845, ENST00000502404, ENST00000513098,	ENST00000393232, ENST00000353868, ENST00000539636, ENST00000311967, ENST00000223190, ENST00000393230, ENST00000393231, ENST00000477428,
Fusion gene scores	* DoF score	4 X 3 X 2=24	4 X 4 X 3=48
	# samples	4	4
	** MAII score	log2(4/24*10)=0.736965594166206 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0	log2(4/48*10)=-0.263034405833794 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context	PubMed: UBE2D3 [Title/Abstract] AND NRF1 [Title/Abstract] AND fusion [Title/Abstract]
Functional or gene categories assigned by FusionGDB annotation

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Hgene	UBE2D3	GO:0000209	protein polyubiquitination	14765125\|16522193
Hgene	UBE2D3	GO:0006513	protein monoubiquitination	20347421
Hgene	UBE2D3	GO:0016567	protein ubiquitination	9990509\|21532592
Hgene	UBE2D3	GO:0043161	proteasome-mediated ubiquitin-dependent protein catabolic process	20347421
Hgene	UBE2D3	GO:0051865	protein autoubiquitination	21068390
Hgene	UBE2D3	GO:0070936	protein K48-linked ubiquitination	20061386
Hgene	UBE2D3	GO:0070979	protein K11-linked ubiquitination	20061386

Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Data type	Source	Cancer type	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChiTaRS3.1			CV341784	UBE2D3	chr4	103717350	+	NRF1	chr7	129269870	+

* LD: Li Ding group's fusion gene list
RV: Roel Verhaak group's fusion gene list
ChiTaRs fusion database

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
intron-intron	ENST00000453744	ENST00000393232	UBE2D3	chr4	103717350	+	NRF1	chr7	129269870	+
intron-intron	ENST00000453744	ENST00000353868	UBE2D3	chr4	103717350	+	NRF1	chr7	129269870	+
intron-intron	ENST00000453744	ENST00000539636	UBE2D3	chr4	103717350	+	NRF1	chr7	129269870	+
intron-intron	ENST00000453744	ENST00000311967	UBE2D3	chr4	103717350	+	NRF1	chr7	129269870	+
intron-intron	ENST00000453744	ENST00000223190	UBE2D3	chr4	103717350	+	NRF1	chr7	129269870	+
intron-intron	ENST00000453744	ENST00000393230	UBE2D3	chr4	103717350	+	NRF1	chr7	129269870	+
intron-intron	ENST00000453744	ENST00000393231	UBE2D3	chr4	103717350	+	NRF1	chr7	129269870	+
intron-intron	ENST00000453744	ENST00000477428	UBE2D3	chr4	103717350	+	NRF1	chr7	129269870	+
intron-intron	ENST00000394801	ENST00000393232	UBE2D3	chr4	103717350	+	NRF1	chr7	129269870	+
intron-intron	ENST00000394801	ENST00000353868	UBE2D3	chr4	103717350	+	NRF1	chr7	129269870	+
intron-intron	ENST00000394801	ENST00000539636	UBE2D3	chr4	103717350	+	NRF1	chr7	129269870	+
intron-intron	ENST00000394801	ENST00000311967	UBE2D3	chr4	103717350	+	NRF1	chr7	129269870	+
intron-intron	ENST00000394801	ENST00000223190	UBE2D3	chr4	103717350	+	NRF1	chr7	129269870	+
intron-intron	ENST00000394801	ENST00000393230	UBE2D3	chr4	103717350	+	NRF1	chr7	129269870	+
intron-intron	ENST00000394801	ENST00000393231	UBE2D3	chr4	103717350	+	NRF1	chr7	129269870	+
intron-intron	ENST00000394801	ENST00000477428	UBE2D3	chr4	103717350	+	NRF1	chr7	129269870	+
intron-intron	ENST00000394803	ENST00000393232	UBE2D3	chr4	103717350	+	NRF1	chr7	129269870	+
intron-intron	ENST00000394803	ENST00000353868	UBE2D3	chr4	103717350	+	NRF1	chr7	129269870	+
intron-intron	ENST00000394803	ENST00000539636	UBE2D3	chr4	103717350	+	NRF1	chr7	129269870	+
intron-intron	ENST00000394803	ENST00000311967	UBE2D3	chr4	103717350	+	NRF1	chr7	129269870	+
intron-intron	ENST00000394803	ENST00000223190	UBE2D3	chr4	103717350	+	NRF1	chr7	129269870	+
intron-intron	ENST00000394803	ENST00000393230	UBE2D3	chr4	103717350	+	NRF1	chr7	129269870	+
intron-intron	ENST00000394803	ENST00000393231	UBE2D3	chr4	103717350	+	NRF1	chr7	129269870	+
intron-intron	ENST00000394803	ENST00000477428	UBE2D3	chr4	103717350	+	NRF1	chr7	129269870	+
intron-intron	ENST00000394804	ENST00000393232	UBE2D3	chr4	103717350	+	NRF1	chr7	129269870	+
intron-intron	ENST00000394804	ENST00000353868	UBE2D3	chr4	103717350	+	NRF1	chr7	129269870	+
intron-intron	ENST00000394804	ENST00000539636	UBE2D3	chr4	103717350	+	NRF1	chr7	129269870	+
intron-intron	ENST00000394804	ENST00000311967	UBE2D3	chr4	103717350	+	NRF1	chr7	129269870	+
intron-intron	ENST00000394804	ENST00000223190	UBE2D3	chr4	103717350	+	NRF1	chr7	129269870	+
intron-intron	ENST00000394804	ENST00000393230	UBE2D3	chr4	103717350	+	NRF1	chr7	129269870	+
intron-intron	ENST00000394804	ENST00000393231	UBE2D3	chr4	103717350	+	NRF1	chr7	129269870	+
intron-intron	ENST00000394804	ENST00000477428	UBE2D3	chr4	103717350	+	NRF1	chr7	129269870	+
intron-intron	ENST00000343106	ENST00000393232	UBE2D3	chr4	103717350	+	NRF1	chr7	129269870	+
intron-intron	ENST00000343106	ENST00000353868	UBE2D3	chr4	103717350	+	NRF1	chr7	129269870	+
intron-intron	ENST00000343106	ENST00000539636	UBE2D3	chr4	103717350	+	NRF1	chr7	129269870	+
intron-intron	ENST00000343106	ENST00000311967	UBE2D3	chr4	103717350	+	NRF1	chr7	129269870	+
intron-intron	ENST00000343106	ENST00000223190	UBE2D3	chr4	103717350	+	NRF1	chr7	129269870	+
intron-intron	ENST00000343106	ENST00000393230	UBE2D3	chr4	103717350	+	NRF1	chr7	129269870	+
intron-intron	ENST00000343106	ENST00000393231	UBE2D3	chr4	103717350	+	NRF1	chr7	129269870	+
intron-intron	ENST00000343106	ENST00000477428	UBE2D3	chr4	103717350	+	NRF1	chr7	129269870	+
intron-intron	ENST00000321805	ENST00000393232	UBE2D3	chr4	103717350	+	NRF1	chr7	129269870	+
intron-intron	ENST00000321805	ENST00000353868	UBE2D3	chr4	103717350	+	NRF1	chr7	129269870	+
intron-intron	ENST00000321805	ENST00000539636	UBE2D3	chr4	103717350	+	NRF1	chr7	129269870	+
intron-intron	ENST00000321805	ENST00000311967	UBE2D3	chr4	103717350	+	NRF1	chr7	129269870	+
intron-intron	ENST00000321805	ENST00000223190	UBE2D3	chr4	103717350	+	NRF1	chr7	129269870	+
intron-intron	ENST00000321805	ENST00000393230	UBE2D3	chr4	103717350	+	NRF1	chr7	129269870	+
intron-intron	ENST00000321805	ENST00000393231	UBE2D3	chr4	103717350	+	NRF1	chr7	129269870	+
intron-intron	ENST00000321805	ENST00000477428	UBE2D3	chr4	103717350	+	NRF1	chr7	129269870	+
intron-intron	ENST00000350435	ENST00000393232	UBE2D3	chr4	103717350	+	NRF1	chr7	129269870	+
intron-intron	ENST00000350435	ENST00000353868	UBE2D3	chr4	103717350	+	NRF1	chr7	129269870	+
intron-intron	ENST00000350435	ENST00000539636	UBE2D3	chr4	103717350	+	NRF1	chr7	129269870	+
intron-intron	ENST00000350435	ENST00000311967	UBE2D3	chr4	103717350	+	NRF1	chr7	129269870	+
intron-intron	ENST00000350435	ENST00000223190	UBE2D3	chr4	103717350	+	NRF1	chr7	129269870	+
intron-intron	ENST00000350435	ENST00000393230	UBE2D3	chr4	103717350	+	NRF1	chr7	129269870	+
intron-intron	ENST00000350435	ENST00000393231	UBE2D3	chr4	103717350	+	NRF1	chr7	129269870	+
intron-intron	ENST00000350435	ENST00000477428	UBE2D3	chr4	103717350	+	NRF1	chr7	129269870	+
intron-intron	ENST00000338145	ENST00000393232	UBE2D3	chr4	103717350	+	NRF1	chr7	129269870	+
intron-intron	ENST00000338145	ENST00000353868	UBE2D3	chr4	103717350	+	NRF1	chr7	129269870	+
intron-intron	ENST00000338145	ENST00000539636	UBE2D3	chr4	103717350	+	NRF1	chr7	129269870	+
intron-intron	ENST00000338145	ENST00000311967	UBE2D3	chr4	103717350	+	NRF1	chr7	129269870	+
intron-intron	ENST00000338145	ENST00000223190	UBE2D3	chr4	103717350	+	NRF1	chr7	129269870	+
intron-intron	ENST00000338145	ENST00000393230	UBE2D3	chr4	103717350	+	NRF1	chr7	129269870	+
intron-intron	ENST00000338145	ENST00000393231	UBE2D3	chr4	103717350	+	NRF1	chr7	129269870	+
intron-intron	ENST00000338145	ENST00000477428	UBE2D3	chr4	103717350	+	NRF1	chr7	129269870	+
intron-intron	ENST00000349311	ENST00000393232	UBE2D3	chr4	103717350	+	NRF1	chr7	129269870	+
intron-intron	ENST00000349311	ENST00000353868	UBE2D3	chr4	103717350	+	NRF1	chr7	129269870	+
intron-intron	ENST00000349311	ENST00000539636	UBE2D3	chr4	103717350	+	NRF1	chr7	129269870	+
intron-intron	ENST00000349311	ENST00000311967	UBE2D3	chr4	103717350	+	NRF1	chr7	129269870	+
intron-intron	ENST00000349311	ENST00000223190	UBE2D3	chr4	103717350	+	NRF1	chr7	129269870	+
intron-intron	ENST00000349311	ENST00000393230	UBE2D3	chr4	103717350	+	NRF1	chr7	129269870	+
intron-intron	ENST00000349311	ENST00000393231	UBE2D3	chr4	103717350	+	NRF1	chr7	129269870	+
intron-intron	ENST00000349311	ENST00000477428	UBE2D3	chr4	103717350	+	NRF1	chr7	129269870	+
intron-intron	ENST00000504211	ENST00000393232	UBE2D3	chr4	103717350	+	NRF1	chr7	129269870	+
intron-intron	ENST00000504211	ENST00000353868	UBE2D3	chr4	103717350	+	NRF1	chr7	129269870	+
intron-intron	ENST00000504211	ENST00000539636	UBE2D3	chr4	103717350	+	NRF1	chr7	129269870	+
intron-intron	ENST00000504211	ENST00000311967	UBE2D3	chr4	103717350	+	NRF1	chr7	129269870	+
intron-intron	ENST00000504211	ENST00000223190	UBE2D3	chr4	103717350	+	NRF1	chr7	129269870	+
intron-intron	ENST00000504211	ENST00000393230	UBE2D3	chr4	103717350	+	NRF1	chr7	129269870	+
intron-intron	ENST00000504211	ENST00000393231	UBE2D3	chr4	103717350	+	NRF1	chr7	129269870	+
intron-intron	ENST00000504211	ENST00000477428	UBE2D3	chr4	103717350	+	NRF1	chr7	129269870	+
intron-intron	ENST00000357194	ENST00000393232	UBE2D3	chr4	103717350	+	NRF1	chr7	129269870	+
intron-intron	ENST00000357194	ENST00000353868	UBE2D3	chr4	103717350	+	NRF1	chr7	129269870	+
intron-intron	ENST00000357194	ENST00000539636	UBE2D3	chr4	103717350	+	NRF1	chr7	129269870	+
intron-intron	ENST00000357194	ENST00000311967	UBE2D3	chr4	103717350	+	NRF1	chr7	129269870	+
intron-intron	ENST00000357194	ENST00000223190	UBE2D3	chr4	103717350	+	NRF1	chr7	129269870	+
intron-intron	ENST00000357194	ENST00000393230	UBE2D3	chr4	103717350	+	NRF1	chr7	129269870	+
intron-intron	ENST00000357194	ENST00000393231	UBE2D3	chr4	103717350	+	NRF1	chr7	129269870	+
intron-intron	ENST00000357194	ENST00000477428	UBE2D3	chr4	103717350	+	NRF1	chr7	129269870	+
intron-intron	ENST00000505207	ENST00000393232	UBE2D3	chr4	103717350	+	NRF1	chr7	129269870	+
intron-intron	ENST00000505207	ENST00000353868	UBE2D3	chr4	103717350	+	NRF1	chr7	129269870	+
intron-intron	ENST00000505207	ENST00000539636	UBE2D3	chr4	103717350	+	NRF1	chr7	129269870	+
intron-intron	ENST00000505207	ENST00000311967	UBE2D3	chr4	103717350	+	NRF1	chr7	129269870	+
intron-intron	ENST00000505207	ENST00000223190	UBE2D3	chr4	103717350	+	NRF1	chr7	129269870	+
intron-intron	ENST00000505207	ENST00000393230	UBE2D3	chr4	103717350	+	NRF1	chr7	129269870	+
intron-intron	ENST00000505207	ENST00000393231	UBE2D3	chr4	103717350	+	NRF1	chr7	129269870	+
intron-intron	ENST00000505207	ENST00000477428	UBE2D3	chr4	103717350	+	NRF1	chr7	129269870	+
intron-intron	ENST00000507845	ENST00000393232	UBE2D3	chr4	103717350	+	NRF1	chr7	129269870	+
intron-intron	ENST00000507845	ENST00000353868	UBE2D3	chr4	103717350	+	NRF1	chr7	129269870	+
intron-intron	ENST00000507845	ENST00000539636	UBE2D3	chr4	103717350	+	NRF1	chr7	129269870	+
intron-intron	ENST00000507845	ENST00000311967	UBE2D3	chr4	103717350	+	NRF1	chr7	129269870	+
intron-intron	ENST00000507845	ENST00000223190	UBE2D3	chr4	103717350	+	NRF1	chr7	129269870	+
intron-intron	ENST00000507845	ENST00000393230	UBE2D3	chr4	103717350	+	NRF1	chr7	129269870	+
intron-intron	ENST00000507845	ENST00000393231	UBE2D3	chr4	103717350	+	NRF1	chr7	129269870	+
intron-intron	ENST00000507845	ENST00000477428	UBE2D3	chr4	103717350	+	NRF1	chr7	129269870	+
intron-intron	ENST00000502404	ENST00000393232	UBE2D3	chr4	103717350	+	NRF1	chr7	129269870	+
intron-intron	ENST00000502404	ENST00000353868	UBE2D3	chr4	103717350	+	NRF1	chr7	129269870	+
intron-intron	ENST00000502404	ENST00000539636	UBE2D3	chr4	103717350	+	NRF1	chr7	129269870	+
intron-intron	ENST00000502404	ENST00000311967	UBE2D3	chr4	103717350	+	NRF1	chr7	129269870	+
intron-intron	ENST00000502404	ENST00000223190	UBE2D3	chr4	103717350	+	NRF1	chr7	129269870	+
intron-intron	ENST00000502404	ENST00000393230	UBE2D3	chr4	103717350	+	NRF1	chr7	129269870	+
intron-intron	ENST00000502404	ENST00000393231	UBE2D3	chr4	103717350	+	NRF1	chr7	129269870	+
intron-intron	ENST00000502404	ENST00000477428	UBE2D3	chr4	103717350	+	NRF1	chr7	129269870	+
intron-intron	ENST00000513098	ENST00000393232	UBE2D3	chr4	103717350	+	NRF1	chr7	129269870	+
intron-intron	ENST00000513098	ENST00000353868	UBE2D3	chr4	103717350	+	NRF1	chr7	129269870	+
intron-intron	ENST00000513098	ENST00000539636	UBE2D3	chr4	103717350	+	NRF1	chr7	129269870	+
intron-intron	ENST00000513098	ENST00000311967	UBE2D3	chr4	103717350	+	NRF1	chr7	129269870	+
intron-intron	ENST00000513098	ENST00000223190	UBE2D3	chr4	103717350	+	NRF1	chr7	129269870	+
intron-intron	ENST00000513098	ENST00000393230	UBE2D3	chr4	103717350	+	NRF1	chr7	129269870	+
intron-intron	ENST00000513098	ENST00000393231	UBE2D3	chr4	103717350	+	NRF1	chr7	129269870	+
intron-intron	ENST00000513098	ENST00000477428	UBE2D3	chr4	103717350	+	NRF1	chr7	129269870	+

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FusionProtFeatures for UBE2D3_NRF1

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
UBE2D3 P61077	NRF1 Q16656

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Fusion gene ID: 40399

FusionGeneSummary for UBE2D3_NRF1

FusionProtFeatures for UBE2D3_NRF1