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Fusion gene ID: 40397 |
FusionGeneSummary for UBE2D3_CA10 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: UBE2D3_CA10 | Fusion gene ID: 40397 | Hgene | Tgene | Gene symbol | UBE2D3 | CA10 | Gene ID | 7323 | 56934 |
| Gene name | ubiquitin conjugating enzyme E2 D3 | carbonic anhydrase 10 | |
| Synonyms | E2(17)KB3|UBC4/5|UBCH5C | CA-RPX|CARPX|HUCEP-15 | |
| Cytomap | 4q24 | 17q21.33-q22 | |
| Type of gene | protein-coding | protein-coding | |
| Description | ubiquitin-conjugating enzyme E2 D3(E3-independent) E2 ubiquitin-conjugating enzyme D3E2 ubiquitin-conjugating enzyme D3ubiquitin carrier protein D3ubiquitin conjugating enzyme E2D 3ubiquitin-conjugating enzyme E2(17)KB 3ubiquitin-conjugating enzyme | carbonic anhydrase-related protein 10CA-RP XCARP Xcarbonic anhydrase Xcarbonic anhydrase-related protein Xcerebral protein-15 | |
| Modification date | 20180523 | 20180522 | |
| UniProtAcc | P61077 | Q9NS85 | |
| Ensembl transtripts involved in fusion gene | ENST00000453744, ENST00000394801, ENST00000394803, ENST00000394804, ENST00000343106, ENST00000321805, ENST00000350435, ENST00000338145, ENST00000349311, ENST00000504211, ENST00000357194, ENST00000505207, ENST00000507845, ENST00000502404, ENST00000513098, | ENST00000570565, ENST00000442502, ENST00000340813, ENST00000451037, ENST00000285273, ENST00000571918, | |
| Fusion gene scores | * DoF score | 4 X 3 X 2=24 | 18 X 7 X 8=1008 |
| # samples | 4 | 18 | |
| ** MAII score | log2(4/24*10)=0.736965594166206 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | log2(18/1008*10)=-2.48542682717024 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: UBE2D3 [Title/Abstract] AND CA10 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | UBE2D3 | GO:0000209 | protein polyubiquitination | 14765125|16522193 |
| Hgene | UBE2D3 | GO:0006513 | protein monoubiquitination | 20347421 |
| Hgene | UBE2D3 | GO:0016567 | protein ubiquitination | 9990509|21532592 |
| Hgene | UBE2D3 | GO:0043161 | proteasome-mediated ubiquitin-dependent protein catabolic process | 20347421 |
| Hgene | UBE2D3 | GO:0051865 | protein autoubiquitination | 21068390 |
| Hgene | UBE2D3 | GO:0070936 | protein K48-linked ubiquitination | 20061386 |
| Hgene | UBE2D3 | GO:0070979 | protein K11-linked ubiquitination | 20061386 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | RV | PRAD | TCGA-EJ-7781-01A | UBE2D3 | chr4 | 103747642 | - | CA10 | chr17 | 49726615 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| Frame-shift | ENST00000453744 | ENST00000570565 | UBE2D3 | chr4 | 103747642 | - | CA10 | chr17 | 49726615 | - |
| Frame-shift | ENST00000453744 | ENST00000442502 | UBE2D3 | chr4 | 103747642 | - | CA10 | chr17 | 49726615 | - |
| Frame-shift | ENST00000453744 | ENST00000340813 | UBE2D3 | chr4 | 103747642 | - | CA10 | chr17 | 49726615 | - |
| Frame-shift | ENST00000453744 | ENST00000451037 | UBE2D3 | chr4 | 103747642 | - | CA10 | chr17 | 49726615 | - |
| Frame-shift | ENST00000453744 | ENST00000285273 | UBE2D3 | chr4 | 103747642 | - | CA10 | chr17 | 49726615 | - |
| 5CDS-5UTR | ENST00000453744 | ENST00000571918 | UBE2D3 | chr4 | 103747642 | - | CA10 | chr17 | 49726615 | - |
| Frame-shift | ENST00000394801 | ENST00000570565 | UBE2D3 | chr4 | 103747642 | - | CA10 | chr17 | 49726615 | - |
| Frame-shift | ENST00000394801 | ENST00000442502 | UBE2D3 | chr4 | 103747642 | - | CA10 | chr17 | 49726615 | - |
| Frame-shift | ENST00000394801 | ENST00000340813 | UBE2D3 | chr4 | 103747642 | - | CA10 | chr17 | 49726615 | - |
| Frame-shift | ENST00000394801 | ENST00000451037 | UBE2D3 | chr4 | 103747642 | - | CA10 | chr17 | 49726615 | - |
| Frame-shift | ENST00000394801 | ENST00000285273 | UBE2D3 | chr4 | 103747642 | - | CA10 | chr17 | 49726615 | - |
| 5CDS-5UTR | ENST00000394801 | ENST00000571918 | UBE2D3 | chr4 | 103747642 | - | CA10 | chr17 | 49726615 | - |
| Frame-shift | ENST00000394803 | ENST00000570565 | UBE2D3 | chr4 | 103747642 | - | CA10 | chr17 | 49726615 | - |
| Frame-shift | ENST00000394803 | ENST00000442502 | UBE2D3 | chr4 | 103747642 | - | CA10 | chr17 | 49726615 | - |
| Frame-shift | ENST00000394803 | ENST00000340813 | UBE2D3 | chr4 | 103747642 | - | CA10 | chr17 | 49726615 | - |
| Frame-shift | ENST00000394803 | ENST00000451037 | UBE2D3 | chr4 | 103747642 | - | CA10 | chr17 | 49726615 | - |
| Frame-shift | ENST00000394803 | ENST00000285273 | UBE2D3 | chr4 | 103747642 | - | CA10 | chr17 | 49726615 | - |
| 5CDS-5UTR | ENST00000394803 | ENST00000571918 | UBE2D3 | chr4 | 103747642 | - | CA10 | chr17 | 49726615 | - |
| In-frame | ENST00000394804 | ENST00000570565 | UBE2D3 | chr4 | 103747642 | - | CA10 | chr17 | 49726615 | - |
| In-frame | ENST00000394804 | ENST00000442502 | UBE2D3 | chr4 | 103747642 | - | CA10 | chr17 | 49726615 | - |
| In-frame | ENST00000394804 | ENST00000340813 | UBE2D3 | chr4 | 103747642 | - | CA10 | chr17 | 49726615 | - |
| In-frame | ENST00000394804 | ENST00000451037 | UBE2D3 | chr4 | 103747642 | - | CA10 | chr17 | 49726615 | - |
| In-frame | ENST00000394804 | ENST00000285273 | UBE2D3 | chr4 | 103747642 | - | CA10 | chr17 | 49726615 | - |
| 5CDS-5UTR | ENST00000394804 | ENST00000571918 | UBE2D3 | chr4 | 103747642 | - | CA10 | chr17 | 49726615 | - |
| In-frame | ENST00000343106 | ENST00000570565 | UBE2D3 | chr4 | 103747642 | - | CA10 | chr17 | 49726615 | - |
| In-frame | ENST00000343106 | ENST00000442502 | UBE2D3 | chr4 | 103747642 | - | CA10 | chr17 | 49726615 | - |
| In-frame | ENST00000343106 | ENST00000340813 | UBE2D3 | chr4 | 103747642 | - | CA10 | chr17 | 49726615 | - |
| In-frame | ENST00000343106 | ENST00000451037 | UBE2D3 | chr4 | 103747642 | - | CA10 | chr17 | 49726615 | - |
| In-frame | ENST00000343106 | ENST00000285273 | UBE2D3 | chr4 | 103747642 | - | CA10 | chr17 | 49726615 | - |
| 5CDS-5UTR | ENST00000343106 | ENST00000571918 | UBE2D3 | chr4 | 103747642 | - | CA10 | chr17 | 49726615 | - |
| In-frame | ENST00000321805 | ENST00000570565 | UBE2D3 | chr4 | 103747642 | - | CA10 | chr17 | 49726615 | - |
| In-frame | ENST00000321805 | ENST00000442502 | UBE2D3 | chr4 | 103747642 | - | CA10 | chr17 | 49726615 | - |
| In-frame | ENST00000321805 | ENST00000340813 | UBE2D3 | chr4 | 103747642 | - | CA10 | chr17 | 49726615 | - |
| In-frame | ENST00000321805 | ENST00000451037 | UBE2D3 | chr4 | 103747642 | - | CA10 | chr17 | 49726615 | - |
| In-frame | ENST00000321805 | ENST00000285273 | UBE2D3 | chr4 | 103747642 | - | CA10 | chr17 | 49726615 | - |
| 5CDS-5UTR | ENST00000321805 | ENST00000571918 | UBE2D3 | chr4 | 103747642 | - | CA10 | chr17 | 49726615 | - |
| intron-3CDS | ENST00000350435 | ENST00000570565 | UBE2D3 | chr4 | 103747642 | - | CA10 | chr17 | 49726615 | - |
| intron-3CDS | ENST00000350435 | ENST00000442502 | UBE2D3 | chr4 | 103747642 | - | CA10 | chr17 | 49726615 | - |
| intron-3CDS | ENST00000350435 | ENST00000340813 | UBE2D3 | chr4 | 103747642 | - | CA10 | chr17 | 49726615 | - |
| intron-3CDS | ENST00000350435 | ENST00000451037 | UBE2D3 | chr4 | 103747642 | - | CA10 | chr17 | 49726615 | - |
| intron-3CDS | ENST00000350435 | ENST00000285273 | UBE2D3 | chr4 | 103747642 | - | CA10 | chr17 | 49726615 | - |
| intron-5UTR | ENST00000350435 | ENST00000571918 | UBE2D3 | chr4 | 103747642 | - | CA10 | chr17 | 49726615 | - |
| In-frame | ENST00000338145 | ENST00000570565 | UBE2D3 | chr4 | 103747642 | - | CA10 | chr17 | 49726615 | - |
| In-frame | ENST00000338145 | ENST00000442502 | UBE2D3 | chr4 | 103747642 | - | CA10 | chr17 | 49726615 | - |
| In-frame | ENST00000338145 | ENST00000340813 | UBE2D3 | chr4 | 103747642 | - | CA10 | chr17 | 49726615 | - |
| In-frame | ENST00000338145 | ENST00000451037 | UBE2D3 | chr4 | 103747642 | - | CA10 | chr17 | 49726615 | - |
| In-frame | ENST00000338145 | ENST00000285273 | UBE2D3 | chr4 | 103747642 | - | CA10 | chr17 | 49726615 | - |
| 5CDS-5UTR | ENST00000338145 | ENST00000571918 | UBE2D3 | chr4 | 103747642 | - | CA10 | chr17 | 49726615 | - |
| In-frame | ENST00000349311 | ENST00000570565 | UBE2D3 | chr4 | 103747642 | - | CA10 | chr17 | 49726615 | - |
| In-frame | ENST00000349311 | ENST00000442502 | UBE2D3 | chr4 | 103747642 | - | CA10 | chr17 | 49726615 | - |
| In-frame | ENST00000349311 | ENST00000340813 | UBE2D3 | chr4 | 103747642 | - | CA10 | chr17 | 49726615 | - |
| In-frame | ENST00000349311 | ENST00000451037 | UBE2D3 | chr4 | 103747642 | - | CA10 | chr17 | 49726615 | - |
| In-frame | ENST00000349311 | ENST00000285273 | UBE2D3 | chr4 | 103747642 | - | CA10 | chr17 | 49726615 | - |
| 5CDS-5UTR | ENST00000349311 | ENST00000571918 | UBE2D3 | chr4 | 103747642 | - | CA10 | chr17 | 49726615 | - |
| intron-3CDS | ENST00000504211 | ENST00000570565 | UBE2D3 | chr4 | 103747642 | - | CA10 | chr17 | 49726615 | - |
| intron-3CDS | ENST00000504211 | ENST00000442502 | UBE2D3 | chr4 | 103747642 | - | CA10 | chr17 | 49726615 | - |
| intron-3CDS | ENST00000504211 | ENST00000340813 | UBE2D3 | chr4 | 103747642 | - | CA10 | chr17 | 49726615 | - |
| intron-3CDS | ENST00000504211 | ENST00000451037 | UBE2D3 | chr4 | 103747642 | - | CA10 | chr17 | 49726615 | - |
| intron-3CDS | ENST00000504211 | ENST00000285273 | UBE2D3 | chr4 | 103747642 | - | CA10 | chr17 | 49726615 | - |
| intron-5UTR | ENST00000504211 | ENST00000571918 | UBE2D3 | chr4 | 103747642 | - | CA10 | chr17 | 49726615 | - |
| intron-3CDS | ENST00000357194 | ENST00000570565 | UBE2D3 | chr4 | 103747642 | - | CA10 | chr17 | 49726615 | - |
| intron-3CDS | ENST00000357194 | ENST00000442502 | UBE2D3 | chr4 | 103747642 | - | CA10 | chr17 | 49726615 | - |
| intron-3CDS | ENST00000357194 | ENST00000340813 | UBE2D3 | chr4 | 103747642 | - | CA10 | chr17 | 49726615 | - |
| intron-3CDS | ENST00000357194 | ENST00000451037 | UBE2D3 | chr4 | 103747642 | - | CA10 | chr17 | 49726615 | - |
| intron-3CDS | ENST00000357194 | ENST00000285273 | UBE2D3 | chr4 | 103747642 | - | CA10 | chr17 | 49726615 | - |
| intron-5UTR | ENST00000357194 | ENST00000571918 | UBE2D3 | chr4 | 103747642 | - | CA10 | chr17 | 49726615 | - |
| intron-3CDS | ENST00000505207 | ENST00000570565 | UBE2D3 | chr4 | 103747642 | - | CA10 | chr17 | 49726615 | - |
| intron-3CDS | ENST00000505207 | ENST00000442502 | UBE2D3 | chr4 | 103747642 | - | CA10 | chr17 | 49726615 | - |
| intron-3CDS | ENST00000505207 | ENST00000340813 | UBE2D3 | chr4 | 103747642 | - | CA10 | chr17 | 49726615 | - |
| intron-3CDS | ENST00000505207 | ENST00000451037 | UBE2D3 | chr4 | 103747642 | - | CA10 | chr17 | 49726615 | - |
| intron-3CDS | ENST00000505207 | ENST00000285273 | UBE2D3 | chr4 | 103747642 | - | CA10 | chr17 | 49726615 | - |
| intron-5UTR | ENST00000505207 | ENST00000571918 | UBE2D3 | chr4 | 103747642 | - | CA10 | chr17 | 49726615 | - |
| intron-3CDS | ENST00000507845 | ENST00000570565 | UBE2D3 | chr4 | 103747642 | - | CA10 | chr17 | 49726615 | - |
| intron-3CDS | ENST00000507845 | ENST00000442502 | UBE2D3 | chr4 | 103747642 | - | CA10 | chr17 | 49726615 | - |
| intron-3CDS | ENST00000507845 | ENST00000340813 | UBE2D3 | chr4 | 103747642 | - | CA10 | chr17 | 49726615 | - |
| intron-3CDS | ENST00000507845 | ENST00000451037 | UBE2D3 | chr4 | 103747642 | - | CA10 | chr17 | 49726615 | - |
| intron-3CDS | ENST00000507845 | ENST00000285273 | UBE2D3 | chr4 | 103747642 | - | CA10 | chr17 | 49726615 | - |
| intron-5UTR | ENST00000507845 | ENST00000571918 | UBE2D3 | chr4 | 103747642 | - | CA10 | chr17 | 49726615 | - |
| intron-3CDS | ENST00000502404 | ENST00000570565 | UBE2D3 | chr4 | 103747642 | - | CA10 | chr17 | 49726615 | - |
| intron-3CDS | ENST00000502404 | ENST00000442502 | UBE2D3 | chr4 | 103747642 | - | CA10 | chr17 | 49726615 | - |
| intron-3CDS | ENST00000502404 | ENST00000340813 | UBE2D3 | chr4 | 103747642 | - | CA10 | chr17 | 49726615 | - |
| intron-3CDS | ENST00000502404 | ENST00000451037 | UBE2D3 | chr4 | 103747642 | - | CA10 | chr17 | 49726615 | - |
| intron-3CDS | ENST00000502404 | ENST00000285273 | UBE2D3 | chr4 | 103747642 | - | CA10 | chr17 | 49726615 | - |
| intron-5UTR | ENST00000502404 | ENST00000571918 | UBE2D3 | chr4 | 103747642 | - | CA10 | chr17 | 49726615 | - |
| 5UTR-3CDS | ENST00000513098 | ENST00000570565 | UBE2D3 | chr4 | 103747642 | - | CA10 | chr17 | 49726615 | - |
| 5UTR-3CDS | ENST00000513098 | ENST00000442502 | UBE2D3 | chr4 | 103747642 | - | CA10 | chr17 | 49726615 | - |
| 5UTR-3CDS | ENST00000513098 | ENST00000340813 | UBE2D3 | chr4 | 103747642 | - | CA10 | chr17 | 49726615 | - |
| 5UTR-3CDS | ENST00000513098 | ENST00000451037 | UBE2D3 | chr4 | 103747642 | - | CA10 | chr17 | 49726615 | - |
| 5UTR-3CDS | ENST00000513098 | ENST00000285273 | UBE2D3 | chr4 | 103747642 | - | CA10 | chr17 | 49726615 | - |
| 5UTR-5UTR | ENST00000513098 | ENST00000571918 | UBE2D3 | chr4 | 103747642 | - | CA10 | chr17 | 49726615 | - |
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FusionProtFeatures for UBE2D3_CA10 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| UBE2D3 | CA10 |