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Fusion gene ID: 4039 |
FusionGeneSummary for BCL2L2-PABPN1_NASP |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: BCL2L2-PABPN1_NASP | Fusion gene ID: 4039 | Hgene | Tgene | Gene symbol | BCL2L2-PABPN1 | NASP | Gene ID | 100529063 | 4678 |
| Gene name | BCL2L2-PABPN1 readthrough | nuclear autoantigenic sperm protein | |
| Synonyms | - | FLB7527|HMDRA1|PRO1999 | |
| Cytomap | 14q11.2 | 1p34.1 | |
| Type of gene | protein-coding | protein-coding | |
| Description | BCL2L2-PABPN1 protein | nuclear autoantigenic sperm proteinNASP histone chaperonehistone H1-binding proteinnuclear autoantigenic sperm protein (histone-binding) | |
| Modification date | 20180519 | 20180523 | |
| UniProtAcc | P49321 | ||
| Ensembl transtripts involved in fusion gene | ENST00000553781, ENST00000557008, | ENST00000402363, ENST00000537798, ENST00000350030, ENST00000372052, ENST00000351223, ENST00000530073, | |
| Fusion gene scores | * DoF score | 5 X 5 X 1=25 | 7 X 8 X 4=224 |
| # samples | 6 | 10 | |
| ** MAII score | log2(6/25*10)=1.26303440583379 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | log2(10/224*10)=-1.16349873228288 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: BCL2L2-PABPN1 [Title/Abstract] AND NASP [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Tgene | NASP | GO:0006335 | DNA replication-dependent nucleosome assembly | 14718166 |
| Tgene | NASP | GO:0006336 | DNA replication-independent nucleosome assembly | 14718166 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| ChiTaRS3.1 | CA446581 | BCL2L2-PABPN1 | chr14 | 23794458 | - | NASP | chr1 | 46080792 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| intron-3CDS | ENST00000553781 | ENST00000402363 | BCL2L2-PABPN1 | chr14 | 23794458 | - | NASP | chr1 | 46080792 | - |
| intron-3CDS | ENST00000553781 | ENST00000537798 | BCL2L2-PABPN1 | chr14 | 23794458 | - | NASP | chr1 | 46080792 | - |
| intron-3CDS | ENST00000553781 | ENST00000350030 | BCL2L2-PABPN1 | chr14 | 23794458 | - | NASP | chr1 | 46080792 | - |
| intron-3CDS | ENST00000553781 | ENST00000372052 | BCL2L2-PABPN1 | chr14 | 23794458 | - | NASP | chr1 | 46080792 | - |
| intron-3CDS | ENST00000553781 | ENST00000351223 | BCL2L2-PABPN1 | chr14 | 23794458 | - | NASP | chr1 | 46080792 | - |
| intron-3UTR | ENST00000553781 | ENST00000530073 | BCL2L2-PABPN1 | chr14 | 23794458 | - | NASP | chr1 | 46080792 | - |
| intron-3CDS | ENST00000557008 | ENST00000402363 | BCL2L2-PABPN1 | chr14 | 23794458 | - | NASP | chr1 | 46080792 | - |
| intron-3CDS | ENST00000557008 | ENST00000537798 | BCL2L2-PABPN1 | chr14 | 23794458 | - | NASP | chr1 | 46080792 | - |
| intron-3CDS | ENST00000557008 | ENST00000350030 | BCL2L2-PABPN1 | chr14 | 23794458 | - | NASP | chr1 | 46080792 | - |
| intron-3CDS | ENST00000557008 | ENST00000372052 | BCL2L2-PABPN1 | chr14 | 23794458 | - | NASP | chr1 | 46080792 | - |
| intron-3CDS | ENST00000557008 | ENST00000351223 | BCL2L2-PABPN1 | chr14 | 23794458 | - | NASP | chr1 | 46080792 | - |
| intron-3UTR | ENST00000557008 | ENST00000530073 | BCL2L2-PABPN1 | chr14 | 23794458 | - | NASP | chr1 | 46080792 | - |
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FusionProtFeatures for BCL2L2-PABPN1_NASP |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| BCL2L2-PABPN1 | NASP |