|
||||||
|
 | |
| |
| |
| |
| |
|
Fusion gene ID: 40260 |
FusionGeneSummary for TYW1_TRA2A |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: TYW1_TRA2A | Fusion gene ID: 40260 | Hgene | Tgene | Gene symbol | TYW1 | TRA2A | Gene ID | 55253 | 29896 |
| Gene name | tRNA-yW synthesizing protein 1 homolog | transformer 2 alpha homolog | |
| Synonyms | RSAFD1|TYW1A|YPL207W | AWMS1|HSU53209 | |
| Cytomap | 7q11.21 | 7p15.3 | |
| Type of gene | protein-coding | protein-coding | |
| Description | S-adenosyl-L-methionine-dependent tRNA 4-demethylwyosine synthaseradical S-adenosyl methionine and flavodoxin domain-containing protein 1radical S-adenosyl methionine and flavodoxin domains 1tRNA wybutosine-synthesizing protein 1 homologtRNA-yW synthe | transformer-2 protein homolog alphaTRA-2 alphaTRA2-alphaTra2alphahtra-2 alphaputative MAPK activating protein PM24transformer-2 alphatransformer-2 protein homolog A | |
| Modification date | 20180519 | 20180523 | |
| UniProtAcc | Q9NV66 | Q13595 | |
| Ensembl transtripts involved in fusion gene | ENST00000359626, ENST00000491969, | ENST00000297071, ENST00000392502, ENST00000538367, ENST00000474586, | |
| Fusion gene scores | * DoF score | 7 X 5 X 6=210 | 5 X 6 X 5=150 |
| # samples | 7 | 7 | |
| ** MAII score | log2(7/210*10)=-1.58496250072116 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(7/150*10)=-1.09953567355091 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: TYW1 [Title/Abstract] AND TRA2A [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Tgene | TRA2A | GO:0000398 | mRNA splicing, via spliceosome | 9546399 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | RV | STAD | TCGA-CG-4443-01A | TYW1 | chr7 | 66582605 | + | TRA2A | chr7 | 23552701 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| In-frame | ENST00000359626 | ENST00000297071 | TYW1 | chr7 | 66582605 | + | TRA2A | chr7 | 23552701 | - |
| In-frame | ENST00000359626 | ENST00000392502 | TYW1 | chr7 | 66582605 | + | TRA2A | chr7 | 23552701 | - |
| In-frame | ENST00000359626 | ENST00000538367 | TYW1 | chr7 | 66582605 | + | TRA2A | chr7 | 23552701 | - |
| 5CDS-5UTR | ENST00000359626 | ENST00000474586 | TYW1 | chr7 | 66582605 | + | TRA2A | chr7 | 23552701 | - |
| intron-3CDS | ENST00000491969 | ENST00000297071 | TYW1 | chr7 | 66582605 | + | TRA2A | chr7 | 23552701 | - |
| intron-3CDS | ENST00000491969 | ENST00000392502 | TYW1 | chr7 | 66582605 | + | TRA2A | chr7 | 23552701 | - |
| intron-3CDS | ENST00000491969 | ENST00000538367 | TYW1 | chr7 | 66582605 | + | TRA2A | chr7 | 23552701 | - |
| intron-5UTR | ENST00000491969 | ENST00000474586 | TYW1 | chr7 | 66582605 | + | TRA2A | chr7 | 23552701 | - |
Top |
FusionProtFeatures for TYW1_TRA2A |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| TYW1 | TRA2A |