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Fusion gene ID: 40233 |
FusionGeneSummary for TXN_NDST3 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: TXN_NDST3 | Fusion gene ID: 40233 | Hgene | Tgene | Gene symbol | TXN | NDST3 | Gene ID | 25828 | 9348 |
| Gene name | thioredoxin 2 | N-deacetylase and N-sulfotransferase 3 | |
| Synonyms | COXPD29|MT-TRX|MTRX|TRX2|TXN | HSST3 | |
| Cytomap | 22q12.3 | 4q26 | |
| Type of gene | protein-coding | protein-coding | |
| Description | thioredoxin, mitochondrialmitochondrial thioredoxin | bifunctional heparan sulfate N-deacetylase/N-sulfotransferase 3GlcNAc N-deacetylase/ N-sulfotransferase 3N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 3N-deacetylase/N-sulfotransferase 3N-heparan sulfate sulfotransferase 3glucosaminyl N-dea | |
| Modification date | 20180527 | 20180329 | |
| UniProtAcc | P10599 | O95803 | |
| Ensembl transtripts involved in fusion gene | ENST00000374515, ENST00000374517, ENST00000487892, | ENST00000296499, ENST00000433996, | |
| Fusion gene scores | * DoF score | 3 X 3 X 3=27 | 2 X 2 X 2=8 |
| # samples | 3 | 2 | |
| ** MAII score | log2(3/27*10)=0.15200309344505 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | log2(2/8*10)=1.32192809488736 | |
| Context | PubMed: TXN [Title/Abstract] AND NDST3 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Tgene | NDST3 | GO:0015012 | heparan sulfate proteoglycan biosynthetic process | 9915799 |
| Tgene | NDST3 | GO:0015014 | heparan sulfate proteoglycan biosynthetic process, polysaccharide chain biosynthetic process | 9915799 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | RV | GBM | TCGA-14-0871-01A | TXN | chr9 | 113013100 | - | NDST3 | chr4 | 119059209 | + |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| intron-3CDS | ENST00000374515 | ENST00000296499 | TXN | chr9 | 113013100 | - | NDST3 | chr4 | 119059209 | + |
| intron-3CDS | ENST00000374515 | ENST00000433996 | TXN | chr9 | 113013100 | - | NDST3 | chr4 | 119059209 | + |
| In-frame | ENST00000374517 | ENST00000296499 | TXN | chr9 | 113013100 | - | NDST3 | chr4 | 119059209 | + |
| In-frame | ENST00000374517 | ENST00000433996 | TXN | chr9 | 113013100 | - | NDST3 | chr4 | 119059209 | + |
| intron-3CDS | ENST00000487892 | ENST00000296499 | TXN | chr9 | 113013100 | - | NDST3 | chr4 | 119059209 | + |
| intron-3CDS | ENST00000487892 | ENST00000433996 | TXN | chr9 | 113013100 | - | NDST3 | chr4 | 119059209 | + |
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FusionProtFeatures for TXN_NDST3 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| TXN | NDST3 |