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Fusion gene ID: 40216 |
FusionGeneSummary for TXNL4B_NR4A1 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: TXNL4B_NR4A1 | Fusion gene ID: 40216 | Hgene | Tgene | Gene symbol | TXNL4B | NR4A1 | Gene ID | 54957 | 3164 |
| Gene name | thioredoxin like 4B | nuclear receptor subfamily 4 group A member 1 | |
| Synonyms | DLP|Dim2 | GFRP1|HMR|N10|NAK-1|NGFIB|NP10|NUR77|TR3 | |
| Cytomap | 16q22.2 | 12q13.13 | |
| Type of gene | protein-coding | protein-coding | |
| Description | thioredoxin-like protein 4BDim1-like protein | nuclear receptor subfamily 4 group A member 1ST-59TR3 orphan receptorearly response protein NAK1growth factor-inducible nuclear protein N10hormone receptornerve growth factor IB nuclear receptor variant 1nuclear hormone receptor NUR/77orphan nucle | |
| Modification date | 20180523 | 20180527 | |
| UniProtAcc | Q9NX01 | P22736 | |
| Ensembl transtripts involved in fusion gene | ENST00000268483, ENST00000423037, ENST00000426362, | ENST00000360284, ENST00000545748, ENST00000550082, ENST00000547206, ENST00000243050, ENST00000394825, ENST00000394824, ENST00000548232, | |
| Fusion gene scores | * DoF score | 6 X 6 X 1=36 | 13 X 13 X 3=507 |
| # samples | 7 | 14 | |
| ** MAII score | log2(7/36*10)=0.959358015502654 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | log2(14/507*10)=-1.85655892005837 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: TXNL4B [Title/Abstract] AND NR4A1 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Tgene | NR4A1 | GO:0002042 | cell migration involved in sprouting angiogenesis | 18059339 |
| Tgene | NR4A1 | GO:0045944 | positive regulation of transcription by RNA polymerase II | 22427340 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| ChiTaRS3.1 | CD517507 | TXNL4B | chr16 | 72120109 | - | NR4A1 | chr12 | 52446078 | + |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| intron-intron | ENST00000268483 | ENST00000360284 | TXNL4B | chr16 | 72120109 | - | NR4A1 | chr12 | 52446078 | + |
| intron-intron | ENST00000268483 | ENST00000545748 | TXNL4B | chr16 | 72120109 | - | NR4A1 | chr12 | 52446078 | + |
| intron-intron | ENST00000268483 | ENST00000550082 | TXNL4B | chr16 | 72120109 | - | NR4A1 | chr12 | 52446078 | + |
| intron-intron | ENST00000268483 | ENST00000547206 | TXNL4B | chr16 | 72120109 | - | NR4A1 | chr12 | 52446078 | + |
| intron-intron | ENST00000268483 | ENST00000243050 | TXNL4B | chr16 | 72120109 | - | NR4A1 | chr12 | 52446078 | + |
| intron-intron | ENST00000268483 | ENST00000394825 | TXNL4B | chr16 | 72120109 | - | NR4A1 | chr12 | 52446078 | + |
| intron-intron | ENST00000268483 | ENST00000394824 | TXNL4B | chr16 | 72120109 | - | NR4A1 | chr12 | 52446078 | + |
| intron-intron | ENST00000268483 | ENST00000548232 | TXNL4B | chr16 | 72120109 | - | NR4A1 | chr12 | 52446078 | + |
| intron-intron | ENST00000423037 | ENST00000360284 | TXNL4B | chr16 | 72120109 | - | NR4A1 | chr12 | 52446078 | + |
| intron-intron | ENST00000423037 | ENST00000545748 | TXNL4B | chr16 | 72120109 | - | NR4A1 | chr12 | 52446078 | + |
| intron-intron | ENST00000423037 | ENST00000550082 | TXNL4B | chr16 | 72120109 | - | NR4A1 | chr12 | 52446078 | + |
| intron-intron | ENST00000423037 | ENST00000547206 | TXNL4B | chr16 | 72120109 | - | NR4A1 | chr12 | 52446078 | + |
| intron-intron | ENST00000423037 | ENST00000243050 | TXNL4B | chr16 | 72120109 | - | NR4A1 | chr12 | 52446078 | + |
| intron-intron | ENST00000423037 | ENST00000394825 | TXNL4B | chr16 | 72120109 | - | NR4A1 | chr12 | 52446078 | + |
| intron-intron | ENST00000423037 | ENST00000394824 | TXNL4B | chr16 | 72120109 | - | NR4A1 | chr12 | 52446078 | + |
| intron-intron | ENST00000423037 | ENST00000548232 | TXNL4B | chr16 | 72120109 | - | NR4A1 | chr12 | 52446078 | + |
| intron-intron | ENST00000426362 | ENST00000360284 | TXNL4B | chr16 | 72120109 | - | NR4A1 | chr12 | 52446078 | + |
| intron-intron | ENST00000426362 | ENST00000545748 | TXNL4B | chr16 | 72120109 | - | NR4A1 | chr12 | 52446078 | + |
| intron-intron | ENST00000426362 | ENST00000550082 | TXNL4B | chr16 | 72120109 | - | NR4A1 | chr12 | 52446078 | + |
| intron-intron | ENST00000426362 | ENST00000547206 | TXNL4B | chr16 | 72120109 | - | NR4A1 | chr12 | 52446078 | + |
| intron-intron | ENST00000426362 | ENST00000243050 | TXNL4B | chr16 | 72120109 | - | NR4A1 | chr12 | 52446078 | + |
| intron-intron | ENST00000426362 | ENST00000394825 | TXNL4B | chr16 | 72120109 | - | NR4A1 | chr12 | 52446078 | + |
| intron-intron | ENST00000426362 | ENST00000394824 | TXNL4B | chr16 | 72120109 | - | NR4A1 | chr12 | 52446078 | + |
| intron-intron | ENST00000426362 | ENST00000548232 | TXNL4B | chr16 | 72120109 | - | NR4A1 | chr12 | 52446078 | + |
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FusionProtFeatures for TXNL4B_NR4A1 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| TXNL4B | NR4A1 |