|
||||||
|
 | |
| |
| |
| |
| |
|
Fusion gene ID: 40203 |
FusionGeneSummary for TXNDC5_RREB1 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: TXNDC5_RREB1 | Fusion gene ID: 40203 | Hgene | Tgene | Gene symbol | TXNDC5 | RREB1 | Gene ID | 81567 | 6239 |
| Gene name | thioredoxin domain containing 5 | ras responsive element binding protein 1 | |
| Synonyms | ENDOPDI|ERP46|HCC-2|HCC2|PDIA15|STRF8|UNQ364 | FINB|HNT|LZ321|RREB-1|Zep-1 | |
| Cytomap | 6p24.3 | 6p24.3 | |
| Type of gene | protein-coding | protein-coding | |
| Description | thioredoxin domain-containing protein 5ER protein 46endoplasmic reticulum protein ERp46endoplasmic reticulum resident protein 46endothelial protein disulphide isomeraseprotein disulfide isomerase family A, member 15thioredoxin domain containing 5 (e | ras-responsive element-binding protein 1DNA-binding proteinfinger protein in nuclear bodieshindsight homolograf-responsive zinc finger protein LZ321zinc finger motif enhancer-binding protein 1 | |
| Modification date | 20180523 | 20180523 | |
| UniProtAcc | Q8NBS9 | Q92766 | |
| Ensembl transtripts involved in fusion gene | ENST00000539054, ENST00000379757, ENST00000473453, | ENST00000379933, ENST00000379938, ENST00000334984, ENST00000349384, | |
| Fusion gene scores | * DoF score | 5 X 5 X 2=50 | 9 X 7 X 4=252 |
| # samples | 6 | 9 | |
| ** MAII score | log2(6/50*10)=0.263034405833794 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | log2(9/252*10)=-1.48542682717024 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: TXNDC5 [Title/Abstract] AND RREB1 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Tgene | RREB1 | GO:0045944 | positive regulation of transcription by RNA polymerase II | 8816445 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | RV | PRAD | TCGA-EJ-7782-01A | TXNDC5 | chr6 | 7895339 | - | RREB1 | chr6 | 7176888 | + |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| 5CDS-5UTR | ENST00000539054 | ENST00000379933 | TXNDC5 | chr6 | 7895339 | - | RREB1 | chr6 | 7176888 | + |
| 5CDS-5UTR | ENST00000539054 | ENST00000379938 | TXNDC5 | chr6 | 7895339 | - | RREB1 | chr6 | 7176888 | + |
| 5CDS-5UTR | ENST00000539054 | ENST00000334984 | TXNDC5 | chr6 | 7895339 | - | RREB1 | chr6 | 7176888 | + |
| 5CDS-5UTR | ENST00000539054 | ENST00000349384 | TXNDC5 | chr6 | 7895339 | - | RREB1 | chr6 | 7176888 | + |
| 5CDS-5UTR | ENST00000379757 | ENST00000379933 | TXNDC5 | chr6 | 7895339 | - | RREB1 | chr6 | 7176888 | + |
| 5CDS-5UTR | ENST00000379757 | ENST00000379938 | TXNDC5 | chr6 | 7895339 | - | RREB1 | chr6 | 7176888 | + |
| 5CDS-5UTR | ENST00000379757 | ENST00000334984 | TXNDC5 | chr6 | 7895339 | - | RREB1 | chr6 | 7176888 | + |
| 5CDS-5UTR | ENST00000379757 | ENST00000349384 | TXNDC5 | chr6 | 7895339 | - | RREB1 | chr6 | 7176888 | + |
| 5CDS-5UTR | ENST00000473453 | ENST00000379933 | TXNDC5 | chr6 | 7895339 | - | RREB1 | chr6 | 7176888 | + |
| 5CDS-5UTR | ENST00000473453 | ENST00000379938 | TXNDC5 | chr6 | 7895339 | - | RREB1 | chr6 | 7176888 | + |
| 5CDS-5UTR | ENST00000473453 | ENST00000334984 | TXNDC5 | chr6 | 7895339 | - | RREB1 | chr6 | 7176888 | + |
| 5CDS-5UTR | ENST00000473453 | ENST00000349384 | TXNDC5 | chr6 | 7895339 | - | RREB1 | chr6 | 7176888 | + |
Top |
FusionProtFeatures for TXNDC5_RREB1 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| TXNDC5 | RREB1 |