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Fusion gene ID: 39846 |
FusionGeneSummary for TSPAN31_PAK3 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: TSPAN31_PAK3 | Fusion gene ID: 39846 | Hgene | Tgene | Gene symbol | TSPAN31 | PAK3 | Gene ID | 6302 | 8874 |
| Gene name | tetraspanin 31 | Rho guanine nucleotide exchange factor 7 | |
| Synonyms | SAS | BETA-PIX|COOL-1|COOL1|Nbla10314|P50|P50BP|P85|P85COOL1|P85SPR|PAK3|PIXB | |
| Cytomap | 12q14.1 | 13q34 | |
| Type of gene | protein-coding | protein-coding | |
| Description | tetraspanin-31sarcoma-amplified sequencetransmembrane 4 proteintspan-31 | rho guanine nucleotide exchange factor 7PAK-interacting exchange factor betaRho guanine nucleotide exchange factor (GEF) 7SH3 domain-containing proline-rich protein | |
| Modification date | 20180523 | 20180522 | |
| UniProtAcc | Q12999 | O75914 | |
| Ensembl transtripts involved in fusion gene | ENST00000553221, ENST00000257910, ENST00000547992, ENST00000547472, | ENST00000425146, ENST00000446737, ENST00000372010, ENST00000519681, ENST00000372007, ENST00000518291, ENST00000484442, ENST00000262836, ENST00000360648, ENST00000417227, | |
| Fusion gene scores | * DoF score | 10 X 10 X 6=600 | 3 X 3 X 2=18 |
| # samples | 13 | 3 | |
| ** MAII score | log2(13/600*10)=-2.20645087746743 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(3/18*10)=0.736965594166206 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | |
| Context | PubMed: TSPAN31 [Title/Abstract] AND PAK3 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Tgene | PAK3 | GO:0043547 | positive regulation of GTPase activity | 21048939 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| ChiTaRS3.1 | AB209699 | TSPAN31 | chr12 | 58141952 | + | PAK3 | chrX | 110382559 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| intron-intron | ENST00000553221 | ENST00000425146 | TSPAN31 | chr12 | 58141952 | + | PAK3 | chrX | 110382559 | - |
| intron-intron | ENST00000553221 | ENST00000446737 | TSPAN31 | chr12 | 58141952 | + | PAK3 | chrX | 110382559 | - |
| intron-intron | ENST00000553221 | ENST00000372010 | TSPAN31 | chr12 | 58141952 | + | PAK3 | chrX | 110382559 | - |
| intron-intron | ENST00000553221 | ENST00000519681 | TSPAN31 | chr12 | 58141952 | + | PAK3 | chrX | 110382559 | - |
| intron-intron | ENST00000553221 | ENST00000372007 | TSPAN31 | chr12 | 58141952 | + | PAK3 | chrX | 110382559 | - |
| intron-intron | ENST00000553221 | ENST00000518291 | TSPAN31 | chr12 | 58141952 | + | PAK3 | chrX | 110382559 | - |
| intron-intron | ENST00000553221 | ENST00000484442 | TSPAN31 | chr12 | 58141952 | + | PAK3 | chrX | 110382559 | - |
| intron-intron | ENST00000553221 | ENST00000262836 | TSPAN31 | chr12 | 58141952 | + | PAK3 | chrX | 110382559 | - |
| intron-intron | ENST00000553221 | ENST00000360648 | TSPAN31 | chr12 | 58141952 | + | PAK3 | chrX | 110382559 | - |
| intron-intron | ENST00000553221 | ENST00000417227 | TSPAN31 | chr12 | 58141952 | + | PAK3 | chrX | 110382559 | - |
| 3UTR-intron | ENST00000257910 | ENST00000425146 | TSPAN31 | chr12 | 58141952 | + | PAK3 | chrX | 110382559 | - |
| 3UTR-intron | ENST00000257910 | ENST00000446737 | TSPAN31 | chr12 | 58141952 | + | PAK3 | chrX | 110382559 | - |
| 3UTR-intron | ENST00000257910 | ENST00000372010 | TSPAN31 | chr12 | 58141952 | + | PAK3 | chrX | 110382559 | - |
| 3UTR-intron | ENST00000257910 | ENST00000519681 | TSPAN31 | chr12 | 58141952 | + | PAK3 | chrX | 110382559 | - |
| 3UTR-intron | ENST00000257910 | ENST00000372007 | TSPAN31 | chr12 | 58141952 | + | PAK3 | chrX | 110382559 | - |
| 3UTR-intron | ENST00000257910 | ENST00000518291 | TSPAN31 | chr12 | 58141952 | + | PAK3 | chrX | 110382559 | - |
| 3UTR-intron | ENST00000257910 | ENST00000484442 | TSPAN31 | chr12 | 58141952 | + | PAK3 | chrX | 110382559 | - |
| 3UTR-intron | ENST00000257910 | ENST00000262836 | TSPAN31 | chr12 | 58141952 | + | PAK3 | chrX | 110382559 | - |
| 3UTR-intron | ENST00000257910 | ENST00000360648 | TSPAN31 | chr12 | 58141952 | + | PAK3 | chrX | 110382559 | - |
| 3UTR-intron | ENST00000257910 | ENST00000417227 | TSPAN31 | chr12 | 58141952 | + | PAK3 | chrX | 110382559 | - |
| 3UTR-intron | ENST00000547992 | ENST00000425146 | TSPAN31 | chr12 | 58141952 | + | PAK3 | chrX | 110382559 | - |
| 3UTR-intron | ENST00000547992 | ENST00000446737 | TSPAN31 | chr12 | 58141952 | + | PAK3 | chrX | 110382559 | - |
| 3UTR-intron | ENST00000547992 | ENST00000372010 | TSPAN31 | chr12 | 58141952 | + | PAK3 | chrX | 110382559 | - |
| 3UTR-intron | ENST00000547992 | ENST00000519681 | TSPAN31 | chr12 | 58141952 | + | PAK3 | chrX | 110382559 | - |
| 3UTR-intron | ENST00000547992 | ENST00000372007 | TSPAN31 | chr12 | 58141952 | + | PAK3 | chrX | 110382559 | - |
| 3UTR-intron | ENST00000547992 | ENST00000518291 | TSPAN31 | chr12 | 58141952 | + | PAK3 | chrX | 110382559 | - |
| 3UTR-intron | ENST00000547992 | ENST00000484442 | TSPAN31 | chr12 | 58141952 | + | PAK3 | chrX | 110382559 | - |
| 3UTR-intron | ENST00000547992 | ENST00000262836 | TSPAN31 | chr12 | 58141952 | + | PAK3 | chrX | 110382559 | - |
| 3UTR-intron | ENST00000547992 | ENST00000360648 | TSPAN31 | chr12 | 58141952 | + | PAK3 | chrX | 110382559 | - |
| 3UTR-intron | ENST00000547992 | ENST00000417227 | TSPAN31 | chr12 | 58141952 | + | PAK3 | chrX | 110382559 | - |
| intron-intron | ENST00000547472 | ENST00000425146 | TSPAN31 | chr12 | 58141952 | + | PAK3 | chrX | 110382559 | - |
| intron-intron | ENST00000547472 | ENST00000446737 | TSPAN31 | chr12 | 58141952 | + | PAK3 | chrX | 110382559 | - |
| intron-intron | ENST00000547472 | ENST00000372010 | TSPAN31 | chr12 | 58141952 | + | PAK3 | chrX | 110382559 | - |
| intron-intron | ENST00000547472 | ENST00000519681 | TSPAN31 | chr12 | 58141952 | + | PAK3 | chrX | 110382559 | - |
| intron-intron | ENST00000547472 | ENST00000372007 | TSPAN31 | chr12 | 58141952 | + | PAK3 | chrX | 110382559 | - |
| intron-intron | ENST00000547472 | ENST00000518291 | TSPAN31 | chr12 | 58141952 | + | PAK3 | chrX | 110382559 | - |
| intron-intron | ENST00000547472 | ENST00000484442 | TSPAN31 | chr12 | 58141952 | + | PAK3 | chrX | 110382559 | - |
| intron-intron | ENST00000547472 | ENST00000262836 | TSPAN31 | chr12 | 58141952 | + | PAK3 | chrX | 110382559 | - |
| intron-intron | ENST00000547472 | ENST00000360648 | TSPAN31 | chr12 | 58141952 | + | PAK3 | chrX | 110382559 | - |
| intron-intron | ENST00000547472 | ENST00000417227 | TSPAN31 | chr12 | 58141952 | + | PAK3 | chrX | 110382559 | - |
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FusionProtFeatures for TSPAN31_PAK3 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| TSPAN31 | PAK3 |