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Fusion gene ID: 39809

FusionGeneSummary for TSPAN13_BZW2

Fusion gene summary

Fusion gene information	Fusion gene name: TSPAN13_BZW2
	Fusion gene ID: 39809
		Hgene	Tgene
	Gene symbol	TSPAN13	BZW2
	Gene ID	27075	28969
	Gene name	tetraspanin 13	basic leucine zipper and W2 domains 2
	Synonyms	NET-6\|NET6\|TM4SF13	HSPC028\|MST017\|MSTP017
	Cytomap	7p21.1	7p21.1
	Type of gene	protein-coding	protein-coding
	Description	tetraspanin-13tetraspan NET-6transmembrane 4 superfamily member 13transmembrane 4 superfamily member tetraspan NET-6tspan-13	basic leucine zipper and W2 domain-containing protein 2
	Modification date	20180523	20180523
	UniProtAcc	O95857	Q9Y6E2
	Ensembl transtripts involved in fusion gene	ENST00000262067, ENST00000466195,	ENST00000258761, ENST00000433922, ENST00000432311, ENST00000452975, ENST00000405202, ENST00000407633,
Fusion gene scores	* DoF score	3 X 3 X 2=18	6 X 5 X 3=90
	# samples	4	6
	** MAII score	log2(4/18*10)=1.15200309344505 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0	log2(6/90*10)=-0.584962500721156 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context	PubMed: TSPAN13 [Title/Abstract] AND BZW2 [Title/Abstract] AND fusion [Title/Abstract]
Functional or gene categories assigned by FusionGDB annotation	Tumor suppressor gene involved fusion gene, in-frame but not retained their domain.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner

Gene

GO ID

GO term

PubMed ID

Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Data type	Source	Cancer type	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
TCGA	RV	BLCA	TCGA-XF-AAMG-01A	TSPAN13	chr7	16793655	+	BZW2	chr7	16734459	+

* LD: Li Ding group's fusion gene list
RV: Roel Verhaak group's fusion gene list
ChiTaRs fusion database

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
In-frame	ENST00000262067	ENST00000258761	TSPAN13	chr7	16793655	+	BZW2	chr7	16734459	+
In-frame	ENST00000262067	ENST00000433922	TSPAN13	chr7	16793655	+	BZW2	chr7	16734459	+
5CDS-intron	ENST00000262067	ENST00000432311	TSPAN13	chr7	16793655	+	BZW2	chr7	16734459	+
5CDS-3UTR	ENST00000262067	ENST00000452975	TSPAN13	chr7	16793655	+	BZW2	chr7	16734459	+
5CDS-3UTR	ENST00000262067	ENST00000405202	TSPAN13	chr7	16793655	+	BZW2	chr7	16734459	+
5CDS-3UTR	ENST00000262067	ENST00000407633	TSPAN13	chr7	16793655	+	BZW2	chr7	16734459	+
intron-3CDS	ENST00000466195	ENST00000258761	TSPAN13	chr7	16793655	+	BZW2	chr7	16734459	+
intron-3CDS	ENST00000466195	ENST00000433922	TSPAN13	chr7	16793655	+	BZW2	chr7	16734459	+
intron-intron	ENST00000466195	ENST00000432311	TSPAN13	chr7	16793655	+	BZW2	chr7	16734459	+
intron-3UTR	ENST00000466195	ENST00000452975	TSPAN13	chr7	16793655	+	BZW2	chr7	16734459	+
intron-3UTR	ENST00000466195	ENST00000405202	TSPAN13	chr7	16793655	+	BZW2	chr7	16734459	+
intron-3UTR	ENST00000466195	ENST00000407633	TSPAN13	chr7	16793655	+	BZW2	chr7	16734459	+

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FusionProtFeatures for TSPAN13_BZW2

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
TSPAN13 O95857	BZW2 Q9Y6E2

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Fusion gene ID: 39809

FusionGeneSummary for TSPAN13_BZW2

FusionProtFeatures for TSPAN13_BZW2