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Fusion gene ID: 39713 |
FusionGeneSummary for TSC22D1_BOLA2 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: TSC22D1_BOLA2 | Fusion gene ID: 39713 | Hgene | Tgene | Gene symbol | TSC22D1 | BOLA2 | Gene ID | 8848 | 654483 |
| Gene name | TSC22 domain family member 1 | bolA family member 2B | |
| Synonyms | Ptg-2|TGFB1I4|TSC22 | BOLA2 | |
| Cytomap | 13q14.11 | 16p11.2 | |
| Type of gene | protein-coding | protein-coding | |
| Description | TSC22 domain family protein 1TGFB-stimulated clone 22 homologTGFbeta-stimulated clone 22cerebral protein 2regulatory protein TSC-22transcriptional regulator TSC-22transforming growth factor beta-1-induced transcript 4 proteintransforming growth fac | bolA-like protein 2BolA-like protein 2 member BbolA homolog 2BbolA-like protein 2B | |
| Modification date | 20180522 | 20180519 | |
| UniProtAcc | Q15714 | Q9H3K6 | |
| Ensembl transtripts involved in fusion gene | ENST00000458659, ENST00000501704, ENST00000261489, ENST00000460842, | ENST00000330978, | |
| Fusion gene scores | * DoF score | 13 X 12 X 7=1092 | 19 X 26 X 1=494 |
| # samples | 16 | 28 | |
| ** MAII score | log2(16/1092*10)=-2.77082904603249 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(28/494*10)=-0.819084214639711 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: TSC22D1 [Title/Abstract] AND BOLA2 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Tgene | BOLA2 | GO:0044571 | [2Fe-2S] cluster assembly | 27519415 |
| Tgene | BOLA2 | GO:0097428 | protein maturation by iron-sulfur cluster transfer | 27519415 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| ChiTaRS3.1 | BI046797 | TSC22D1 | chr13 | 45008318 | + | BOLA2 | chr16 | 30080184 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| intron-intron | ENST00000458659 | ENST00000330978 | TSC22D1 | chr13 | 45008318 | + | BOLA2 | chr16 | 30080184 | - |
| intron-intron | ENST00000501704 | ENST00000330978 | TSC22D1 | chr13 | 45008318 | + | BOLA2 | chr16 | 30080184 | - |
| intron-intron | ENST00000261489 | ENST00000330978 | TSC22D1 | chr13 | 45008318 | + | BOLA2 | chr16 | 30080184 | - |
| intron-intron | ENST00000460842 | ENST00000330978 | TSC22D1 | chr13 | 45008318 | + | BOLA2 | chr16 | 30080184 | - |
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FusionProtFeatures for TSC22D1_BOLA2 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| TSC22D1 | BOLA2 |